Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.0011 0.39 13.8 5.6 1 21 139 159 139 160 0.93

2 5 0.00044 0.15 15.1 0.4 2 23 169 191 168 191 0.93

3 5 6.1e-05 0.021 17.8 0.3 2 23 198 220 197 220 0.93

4 5 3.4e-05 0.012 18.6 0.6 2 23 227 249 226 249 0.92

5 5 1.9e-05 0.0065 19.4 5.1 2 23 256 278 255 278 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.0011	0.39	13.8	5.6	1	21	139	159	139	160	0.93
2	5	0.00044	0.15	15.1	0.4	2	23	169	191	168	191	0.93
3	5	6.1e-05	0.021	17.8	0.3	2	23	198	220	197	220	0.93
4	5	3.4e-05	0.012	18.6	0.6	2	23	227	249	226	249	0.92
5	5	1.9e-05	0.0065	19.4	5.1	2	23	256	278	255	278	0.93

Coding Sequence: ATGGtattagttaaaaatgaaaCTAATTCTGCAATTAATATAAAGTCTGAGAAAGACAGTAGCCAGTCTCTGAATAATGACAGCGTTGGAATATTTCCAGAAACgTTAGATGTAAAAAATCAATATGACGTAGACTTAAATGAACCCCCAATGATTAAACATGAATCAGTAGACCTCAAAACTGAAACCTATATCATACCTGATTTCGTACCCGAAGGAACCTATATCGTACCTGATTTAATACCTGAAAAAACCGATGGAAATTTTGGCGATTTGGTAGTTTTCGAAAACCAGATTCACCACGAACGTACAACCGAACCTCCGAAAAACCATCAGAGTATATCTGTCAAAGATTTCTCGCTCGAAGGGAAATTAGAACGTCATCGTAATGAAGAATGCgcaaaaatttacaagtttagtTGTCATACGtgcgataaaaaatttgtttctacgGATGATTTTAAAAAGCACGAATGCAAAATATACAAGAAACTTCGAAGATGGATGTGCGATCAGTGCGATGAAATTTTTTGTCGCGAACAGTCTTTAAGAGCTCACGAGTCTATCATGCATTCCAAGATCCACGAATGGAAATGTGAGATATgcgcgaaaatttttaaatacaaacgGAATTTAAGAATTCATGAGTCTATCGTGCATCGACAAACCAAAGCTTGGAAATGTAATCTGTGTGAAAGATCATTTTCTTCGAAACAGTATTTGCAATCTCATGAGAACGCTGTACACTTGAAAACTCAAAATTGGAAATGTAAGCATTGCGAAAAGTCTTTTAGCTATCAGTGTAATTTGACAAGGCATGAGCAGGAAGTACACTTGAACATCCGAAAACACAAAAATGTCCATATTGTGAAAAGTCGTTTAGCATTAGATCTAATGTAA
Protein Sequence: MVLVKNETNSAINIKSEKDSSQSLNNDSVGIFPETLDVKNQYDVDLNEPPMIKHESVDLKTETYIIPDFVPEGTYIVPDLIPEKTDGNFGDLVVFENQIHHERTTEPPKNHQSISVKDFSLEGKLERHRNEECAKIYKFSCHTCDKKFVSTDDFKKHECKIYKKLRRWMCDQCDEIFCREQSLRAHESIMHSKIHEWKCEICAKIFKYKRNLRIHESIVHRQTKAWKCNLCERSFSSKQYLQSHENAVHLKTQNWKCKHCEKSFSYQCNLTRHEQEVHLNIRKHKNVHIVKSRLALDLM*

Sequence clustering based on sequence similarity using MMseqs2