Basic Information

Gene Symbol
-
Assembly
GCA_949128115.1
Location
OX421967.1:10469851-10470975[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.13 6.9 8.6 0.2 2 20 68 86 67 88 0.93
2 9 5e-05 0.0028 19.3 3.7 2 23 132 153 131 153 0.97
3 9 0.00096 0.053 15.2 2.4 2 23 163 184 162 184 0.96
4 9 0.00074 0.041 15.6 1.1 1 23 193 215 193 215 0.98
5 9 0.0014 0.076 14.7 1.3 1 23 223 245 223 245 0.98
6 9 0.0019 0.1 14.3 0.6 3 23 256 276 256 276 0.99
7 9 0.0015 0.081 14.6 4.5 1 23 285 307 285 307 0.98
8 9 3.9e-05 0.0021 19.6 0.9 1 23 316 338 316 338 0.98
9 9 0.0016 0.086 14.6 0.8 1 23 347 369 347 369 0.96

Sequence Information

Coding Sequence
ATGAACCATAAACATGACAACGCGACTGAACCATTCCATGCCGTGGTTCAGCCAGAGCTGTATCCTTGCATTTGTTGCGATTACAAAAGACGTTACAAGTCTAACCTGTATGAACATTGCGTTGACAAACACGACGCTGCTACTATCTTGAAAAGCACAAGCATCAACAGCCGTCAGTCGTATgaacaatcgaaacattggcctTGCGAGTACTGCAAGTACAAAAGCAATTCAAGTTTATTGCTGATTAAGCATCAAGATTCATGCACAATGGAACTGAAAGATCCAATAGAATCTGTGACCTTACAAGCTATGTCCGCAATAGGACCTCATCACAACGCCACTGCAAGACTCGCAAATTTCATACCCAGCTCAACGTTGAGACACGGTATTCAATGCGAGCATTGTTCGTACAGAAGTAGAACCAAATCGAACTTGACGaagcacatgttgcaacacgcATCGTTTGCGGAGATCGACTGGTTGAGTTGCACCAAATGTTCGTTTCGGACGAAGCGGAAGGGAACgttgaaaacgcacatgctgGTGCACGCCGCGGCCGACGCCATCACCTGGTTCAGTTGCACCGAATGTTCGTACCGCGCCAAGCAAAAGGGAACGCTGAAAGACCACTTGCTGACGCACGCTTCCACCAACGAAGTGTGGTTCAGCTGCACCGAGTGTGCGTACACCGGCAAACAGAAGCGCTACCTGAAAGAGCACATGTTGAGCCACGCCGCGGCCGACGACCTCAACTGGCTGGGCTGCACCGAATGTCCGTACCGTGCCGTACTGAAGAAGAACCTGAAAAGGCACATGCTGATGCACGCTGCGGACGACGAAATCGAATGGTTCGAGTGCACGCAGTGTCCGTATCGGGCCAAGCACAAGCGCAACTTGAAGTATCACATGTCGAAGCATGCCGCGGCCGATGACGCGGCTTGGTTCAATTGTACGGAGTGTTCGTATCAGTCTGCCGACAAGGGAAatctgaaaaagcacatgttgacgCACGCCGCCGCCAATGATATCGACTGGTTTTATTGCGGCGAGTGTTCGTATCGTGGTAAAATGAAATCGGACTTGAATCGGCACATGGTGAACCATCGCAAATGCTTCAGTTGA
Protein Sequence
MNHKHDNATEPFHAVVQPELYPCICCDYKRRYKSNLYEHCVDKHDAATILKSTSINSRQSYEQSKHWPCEYCKYKSNSSLLLIKHQDSCTMELKDPIESVTLQAMSAIGPHHNATARLANFIPSSTLRHGIQCEHCSYRSRTKSNLTKHMLQHASFAEIDWLSCTKCSFRTKRKGTLKTHMLVHAAADAITWFSCTECSYRAKQKGTLKDHLLTHASTNEVWFSCTECAYTGKQKRYLKEHMLSHAAADDLNWLGCTECPYRAVLKKNLKRHMLMHAADDEIEWFECTQCPYRAKHKRNLKYHMSKHAAADDAAWFNCTECSYQSADKGNLKKHMLTHAAANDIDWFYCGECSYRGKMKSDLNRHMVNHRKCFS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-