Basic Information

Gene Symbol
Zfx
Assembly
GCA_949128115.1
Location
OX421961.1:115138152-115161247[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 24 0.0028 0.15 13.8 0.9 1 23 95 117 95 117 0.98
2 24 0.05 2.7 9.8 0.2 1 23 123 145 123 145 0.97
3 24 0.0013 0.07 14.8 0.2 2 23 151 172 150 172 0.96
4 24 0.047 2.6 9.9 0.4 1 23 178 200 178 200 0.98
5 24 2.9 1.6e+02 4.3 0.1 2 23 210 231 209 231 0.95
6 24 1e-06 5.6e-05 24.6 0.6 3 23 257 277 256 277 0.99
7 24 1.2e-05 0.00068 21.2 1.1 1 23 283 305 283 305 0.98
8 24 0.00047 0.026 16.2 0.5 1 23 311 334 311 334 0.96
9 24 0.57 32 6.5 5.3 1 23 344 367 344 367 0.96
10 24 1.2e-06 6.6e-05 24.3 1.2 1 23 456 478 456 478 0.98
11 24 0.005 0.28 13.0 5.2 1 23 484 506 484 507 0.95
12 24 0.0034 0.19 13.5 3.7 1 23 513 535 513 535 0.98
13 24 0.014 0.75 11.6 4.3 1 23 587 609 587 609 0.99
14 24 0.014 0.77 11.6 3.9 1 23 615 637 615 637 0.96
15 24 1.5e-06 8.4e-05 24.0 0.6 1 23 643 665 643 665 0.98
16 24 0.072 4 9.3 5.3 1 23 671 693 671 693 0.98
17 24 0.069 3.8 9.4 1.9 1 23 1003 1025 1003 1025 0.96
18 24 1.2e-05 0.00068 21.2 5.8 1 23 1035 1057 1035 1057 0.98
19 24 0.0001 0.0056 18.3 1.4 1 23 1063 1085 1063 1085 0.97
20 24 0.014 0.79 11.5 1.6 3 23 1095 1115 1093 1115 0.91
21 24 1.1 59 5.6 4.1 1 23 1121 1144 1121 1144 0.89
22 24 0.0017 0.095 14.4 4.3 1 23 1290 1312 1290 1312 0.97
23 24 0.00032 0.018 16.7 0.2 1 23 1318 1340 1318 1340 0.97
24 24 0.0014 0.079 14.7 2.7 1 23 1345 1368 1345 1368 0.97

Sequence Information

Coding Sequence
atggcagaaggAAATTATAACAAGGACgaaatttcaacatttattgCACTGCCAGTGGTCATGTGCGACAATAATCCGACTGAACTTCCCGAACAACTGGCTTTCAAAAATGTGATAATCCAAAAACTAGATGACGGCACAATATGCCTTATCGACGCCACAAACCTCAACATCAGCAAACTGACCCTGGACAATGACACACTTACAGTGTCGCAAGACCGAGCAATCGAACCGGCTCCATACAAATCCGAACAGCCGGAACAAAGTCAGCAGCCGCAAACGTACGAGTGCCTGAGCTGCCCACGATACTTTGAAAACGTCCACGAGCTCCGGAAACACATCGCCACCCATCGCCTATCAAAACTATACACATGCGAAAAATGCTCGGTCGGGTACAACGAAGAAGTCAACTTCAAAATACACATGGCATTGCACTCTGATGGAAAATTGTCCTGTCCGATATGCAACATAAATTTCCAAAGGTTGGCCAGTTTGAAATCGCATTTGATGCTACATCAAGTTGAGGAACTGTATTCCTGCCAGGAATGCTCGGCCGAGTTCGAGAAAGAGGATGAACTGGACAAGCACTTCCAAAGCCATTGGAAAGAGAGCAGCAAAAGCACTTTGGTCTGTGGATATTGTTTGTTGGAGTTGAATAATAAAGCAGAGTACAAAGAACATGTTTCATCACATGTGCAAatgaaaaaaactGTGTTATCTGGAAAGAAAACTCGGAAAACTAACAGTGGAAAAGAGTGGAGTCATGGTTGTACAGAATGTGATAAAAAGTTCTCAAAAGCCTCGCTTTTAGAGAGGCACATGAGGGTTCATAGTGGAGAACGTCCTTTTGTTTGCGAATATTGCAAGAAAGGTTTCAACCAGAAGGGCACTCTCCAAATCCACTTGAACAAACACCTGGGACTGAAACCGTACGAATGCACCCTCTGCTCCGCCAAGTTCAACCAGAAAGGCAACCTGAGAGTGCACGTTGAAAAAACCCACACTGCCCCGACGCCCGGCATCAAAACGTTCAAGTGCGCGCACTGCACGTGCATTTTCAAAAAGATAGCCTCCCTGAACGTGCACACCACCAAGTTCCATTCGCACAAGGATCCCTCGGAAGACATCACGGCCGTTCTGACGCAACTGAAAGAGCTCGACAGACAGATCAAATCGGGAAAGACGAACGACATACAGAAATTCGAAAAGGAGCTCGTCGAACAAAACCGAAAGGTCCTGGACGAAATCACCGATCAGAACGCCGCCGCGTCCGACATAACTTACGTGAAACTGGCGGAATCGTTCCTCGACGGCACCGTCCGCCGGTACATCGTCAAGAGAAAAATAGTCAACGAAACTAAATTCTACATTTGCAACTATTGCAAAAAGGAGTTCAAGAAACCGTCGGATTTGATCAGGCACACCAGGGTGCACACGCGAGAAAAACCGTTCCAGTGCAACAAATGCGGCGCTTCGTTTACGCTCAAGTGCACCCTGATGAACCACACCAAGGCCCACCATTCCGGAGCGAACACTTTCACGTGCTACATTTGCTACAGGAAGTTCAACTACGCTCGTTCGCTGAAGATGCATTTGAAAAAACATCTCTACGGAAAGCTGAAGGCAAGCAGGGCTCCAAAACCGGTAGCGCAGGGCGACGAGCCAGTGAAAATTACGTTGAGTCAGCCTCTGGTGGAAACAGATAGTGGCCTCATGACGGTGGTGAATTCGAAGGCGGAAAGTCAGGAGAAGGGTCAATATCAGTGCCAGGTTTGCAAGTCGTGCTATTTGAAGCCCAGGAATCTCCGAAGGCACATGCAGACGCACACTCGAGAGAAGAGGTTCAGATGTGATCAGTGTCCCAAATGCTACTTCACGCGGCAACAGTTGATGATCCATTCGTCCAGCCACACCGGCATCAAAAACTACGCCTGTCCCATCTGCAAGAAGAAATACGTCACATCGTCCACGTTGACCCGCCACATGGTCACTCACAATCCGGGCAAGCCTTACGTGTGTCCTTACTGTCGGAAACATTTCAAGAGCGTCAACATGTGCAGAAAACACATAAATATCCACAAAAAAGATCTGTTACAGCTTGTAGAGGTAGCAGATTGGAAATACACAGAAGGATCGAAAAGTATTGAAGACGCACAGAACAAGCTACCAGACACGTTCATCAACCCAACGGATATGTTGAATTCTTCTCGAGATGACAGTCAGAAACAGCCACAAGAAAAATCTACTTCACCAGAAAAAGATCCGCTTCTAATTCAATCCAACGTTACCATCAATCAAATCGATAACATTCCTCAAATTAGCGTCCCAGAAGTTAGTTCAAATCAAATGGAACTTTTGCAGCAAATAACCGGTAGTTCCATACAACTGATTGCTAAAGACGATCATAATGCATTGCAGACGATTTTTGTCAACTGCCAAGatttgcagttgcaagacaatAGCGGGGCTTTGTGCAACAACACTTTGTACACCGGAAAATTCAAGTCAGAAAATTCAGAGTTGCTCTTTAATTCTCTCAAAGAACTCCAAGACAGCACTGTTTTTAACATCGACAACCTAAACGATTTCGAACCATCCGTTCCACGAGCAACAGAACATTTCAATAATAATCAAATGTTCAACGTTGATCATATTATCAATACTGAAACACACATAGCTCCAGATTTAAGTCCGGGTAAAATACTGAGTTCTGATCCTGTACCAAAAAAATCCAGTGATAAAAACGACGAGAGCCACGTCCCCCCTATGGATATCACCATAAACGACGGGATCTTGACCAGCAACGTGCCGTATTATTCCACGCCGGATGTAAATTTGTATTTCAACATCGACGCAGACTTGGACCCACCGCCTAGCGACTTACCAACTCCATTGCCAGACAAGATCAACTTGAGCACTGGGCCGGAAACTATCCAGGAAAAACTAGAACAGCGGCTTCCCGTGCCGAGCAACTTGGAAAAGGAAGACTCGAGTTCGAAAAAGAAGTTCATCTGTTTGCACTGTAAGCGAGGTTTTGATATGAAGAATTCGTGGAAAAAGCACGTGGCCAGTCATGACAAGAAGCCGTCGACAGGTCCGACCCATACGTGCATGTTTTGTCAAAAGACGTTCAAGAAACAATCGGATTTGACGCGACATATAAGAACGCACACTGGGGAAAGACCGTTTGCCTGCGACAAGTGCGACAGGAAGTTCACTTTGAAATCGACGTTGGTGTCGCACGAACGTACTCACGATCCCGTCAGCCACAAAAGTCACAATTGCATTGTGTGCAATTCTTTTTTCACGTCTAAATCCGGCTTGAGGGTTCACATGAACATACATACAGGTGCCAAGCCCCACGCCTGCACTTTCTGCACGCAACGATTCACAACCTCTGCTCACAAACGCTCGCACGAGTCCTTGGCCCACAACGCATCGAAGAAAAAATCccacaacaaaaaagtcaccGACATGTTATCTTCAATTGCCATGGACGTAGTCGGTTCTCAGCCCGAAGCCGAGCATAGCCTCGACATTACCAGCGAAGACTTGGAAAACGTGTTAGTGGTACAACAGCAGCTTCCTCCAGAATCAGACAACTTGAACCTTCTGAACGAACCGGCGATTGCGAGTACCCTCACGGACGCGATACAGTTCGACCCGGCCATCCTGCAGCAGCTGCAATCGACGCAGTTCTTATTCCAAGATCAACTGATATCGCCCCAGTCCGTGATCCAGTTGGACGATGGCACTCTGTTGAACATCAAATCGATAAGCAGCGATCTGGTGGCTCCGGTTGATGCTCTGACGGCAGAGCCAGAAGTGGCGAAGACTGTCGTGAAAAAGCCGGAAAAGGAGCGGAATCACGAGTGCGACATTTGCCATAAAAAGTACGCCTCCAAAGATGTGCTGAGGAAACACAAAAAGATCCACGGCCAGAACAAGAAGTTCCCTTGCAGCAAATGCGATAAAGGGTTCGACACCGAAACCGCGCTGACTGAGCACGAGAAGGTGCATTTGGGCTATCAGTTCCCGTGCATGTACTGCGCTAATAGCTTCACGCACCAACAAAGTCTAACTACGCATATGAAGAggattcataaCATTTCGAGCACGCCTTTGAGAGACAATTTGTTCTTGTACACTCTGAAGGAATAA
Protein Sequence
MAEGNYNKDEISTFIALPVVMCDNNPTELPEQLAFKNVIIQKLDDGTICLIDATNLNISKLTLDNDTLTVSQDRAIEPAPYKSEQPEQSQQPQTYECLSCPRYFENVHELRKHIATHRLSKLYTCEKCSVGYNEEVNFKIHMALHSDGKLSCPICNINFQRLASLKSHLMLHQVEELYSCQECSAEFEKEDELDKHFQSHWKESSKSTLVCGYCLLELNNKAEYKEHVSSHVQMKKTVLSGKKTRKTNSGKEWSHGCTECDKKFSKASLLERHMRVHSGERPFVCEYCKKGFNQKGTLQIHLNKHLGLKPYECTLCSAKFNQKGNLRVHVEKTHTAPTPGIKTFKCAHCTCIFKKIASLNVHTTKFHSHKDPSEDITAVLTQLKELDRQIKSGKTNDIQKFEKELVEQNRKVLDEITDQNAAASDITYVKLAESFLDGTVRRYIVKRKIVNETKFYICNYCKKEFKKPSDLIRHTRVHTREKPFQCNKCGASFTLKCTLMNHTKAHHSGANTFTCYICYRKFNYARSLKMHLKKHLYGKLKASRAPKPVAQGDEPVKITLSQPLVETDSGLMTVVNSKAESQEKGQYQCQVCKSCYLKPRNLRRHMQTHTREKRFRCDQCPKCYFTRQQLMIHSSSHTGIKNYACPICKKKYVTSSTLTRHMVTHNPGKPYVCPYCRKHFKSVNMCRKHINIHKKDLLQLVEVADWKYTEGSKSIEDAQNKLPDTFINPTDMLNSSRDDSQKQPQEKSTSPEKDPLLIQSNVTINQIDNIPQISVPEVSSNQMELLQQITGSSIQLIAKDDHNALQTIFVNCQDLQLQDNSGALCNNTLYTGKFKSENSELLFNSLKELQDSTVFNIDNLNDFEPSVPRATEHFNNNQMFNVDHIINTETHIAPDLSPGKILSSDPVPKKSSDKNDESHVPPMDITINDGILTSNVPYYSTPDVNLYFNIDADLDPPPSDLPTPLPDKINLSTGPETIQEKLEQRLPVPSNLEKEDSSSKKKFICLHCKRGFDMKNSWKKHVASHDKKPSTGPTHTCMFCQKTFKKQSDLTRHIRTHTGERPFACDKCDRKFTLKSTLVSHERTHDPVSHKSHNCIVCNSFFTSKSGLRVHMNIHTGAKPHACTFCTQRFTTSAHKRSHESLAHNASKKKSHNKKVTDMLSSIAMDVVGSQPEAEHSLDITSEDLENVLVVQQQLPPESDNLNLLNEPAIASTLTDAIQFDPAILQQLQSTQFLFQDQLISPQSVIQLDDGTLLNIKSISSDLVAPVDALTAEPEVAKTVVKKPEKERNHECDICHKKYASKDVLRKHKKIHGQNKKFPCSKCDKGFDTETALTEHEKVHLGYQFPCMYCANSFTHQQSLTTHMKRIHNISSTPLRDNLFLYTLKE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-