Basic Information

Gene Symbol
-
Assembly
GCA_947563765.1
Location
OX387416.1:748146-750104[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 0.00028 0.018 15.8 4.4 1 23 89 111 89 111 0.99
2 16 0.0028 0.18 12.7 1.5 1 23 116 139 116 139 0.97
3 16 0.001 0.066 14.0 0.6 2 23 165 186 164 186 0.96
4 16 0.19 13 6.9 0.6 1 23 225 248 225 248 0.95
5 16 0.0008 0.052 14.4 0.1 1 20 254 273 254 274 0.94
6 16 0.0016 0.1 13.5 6.0 1 23 296 318 296 318 0.98
7 16 0.095 6.2 7.8 0.5 2 23 324 346 324 346 0.95
8 16 0.0042 0.27 12.1 2.1 1 23 356 378 356 378 0.99
9 16 0.33 21 6.2 4.8 1 23 384 406 384 406 0.96
10 16 0.0075 0.48 11.3 0.9 2 23 413 433 413 433 0.97
11 16 1.9 1.2e+02 3.8 5.5 2 21 475 494 471 496 0.54
12 16 0.033 2.1 9.3 3.0 2 23 501 523 500 523 0.96
13 16 3.2e-05 0.0021 18.8 1.2 1 23 529 551 529 551 0.97
14 16 3.2e-05 0.0021 18.8 1.9 1 23 558 580 558 580 0.96
15 16 0.15 10 7.2 1.3 1 23 586 609 586 609 0.96
16 16 0.00071 0.046 14.5 0.8 3 21 616 634 614 635 0.93

Sequence Information

Coding Sequence
ATGATACTAAAACTGAAGACAAACCACATAGTCATACAAAAATACATGAATATCCTATCAGAACAAGTGAAGCAAAGTCCAAATACTGAGTCACAAGAAGAAAAAGAGTTAGTTTTGACAATAGACAACGTTAACAGCCTAAACGTACCAACAACAGTCTCAAAAATACCGAAAGAAACAAATAATGTTACGCAAATATTCTTATGTGATGTTGATACCAAAAATATAGTCGTTTGGGACAAAAATAGCCAAGATGTACTAAAATACAAATGTCCTTATTGCAACAAGAAATTCGCATATCACAGGTCAATAATAAATCATCGCAACAAACATAAAGATGAATTCTACCGATGTACAAACTGTACAGAACTATTTAAAGGATTTAAAGATTTAATGAGACACAGAAAAGTGGTTCATTCAGAGAGAATATCTACTTGTGATATTTGTAGAATTATTTTACTAAATGAAGATTGCGAGCATAAAAAAGGTTTGATCTGTGAACTATGTCAGATAAGTTTCAATTCTAAAACTGAATTGGTTAATCATAACAAGAAACATTTAAAGAGTCTGCATAATTTTGAAAATACAGACTGCTCGGAATGCAAAGATGAATGTATACATAAACCCTATTTAAACTGGTTTAATGCGCAACAATTAGCTAATAAAATTACATTTCAATGTTTAACTTGCAATGTCGAACATACAACTAAAGACGAATTAATAACTCACGTGAATGAAGAACATTTACAACATTCTTCATACCTTTGTGAATTATGCGGTCAAAGTTTTTCATCGCAGTTACTATTATCCAAGCATATAGGTTGCCATGAAACTGAGTCTGTTATTAAAAAAACTAGGGTTTATATACCAATACCTTTAAAAACATTTGAGTGCAAATTGTGTGGATATTGCTTCTTTAATGAGAAATTTTACAGAGCTCATAGAAGGAAACACATGAGCGGGGAAAACGAATGCCAATACTGCCAAAGGCTGTTCTACAATATAAATAGATTAAACATGCATATTGCTAAAGATCATAAGAATGAAAACCCTAATAATATGTTCTACAAATGCTCAATGTGCACTTCAGACTTTGACTCGAGGAAAGAATATTTAAAACACATAACAACACACCCAAAGGACTCTAAACATATTTGTAGAGTTTGCAAAGCATCGTGTACATCAAAACGAAGTTACCTTCTCCATGTAAAAAGCCACAAACAAACATACGATAGAGAATGTCCGGTTTGCTTCAAAATGTACACGTTACAAACTATACAGCGACATATGAAAACACATTTGAAAGAAAATTGGAAGGATGGTGGAGGCCCTAAGGCTTGTGACATCTGTGGACAGTTATTACTGAGCGATAAAGGGTTAATAAAACATTCAAAAACTCATAAAGAAGAACAACAGTGTCCGTATTGTCACAAATGTGTTAAAGTTATATTTTTCAATGAACATTTAAACACGCACTCTGAAAAACATAGAACAATAAAGCAATGTCAACAATGTGATTATACGACAAGATTTTCACCATGTTTACAGGCACATGTGAATCGATTTCATTTAAAATCTAGACCGTTTCAATGTACCGTTTGCAATAAGACTTTTTACTCGGAATATACTCTAAAAGGTCACCAAGTAGTCCATAATGATACAAGGCAGGAGCATTTCTGTGAAATGTGTGGTAAGAAATTCATCAGCACTAAAGCTTTGATGCTTCACATGAGATTACATACAGGAGAGACACCGTACCCCTGTGATTTATGCAAATTAAGTTTTTTGTCTTCGAGTAGGAGACGTCAGCATATGATTAGAAAACACTTTGAACCGAGTATTGCGTGTGATATTTGTCATAAGAAAATGTATACGCAAAGTGATTTAAAAAGGCATATGACGAAATGTGCTGGTAAAGAGACAATAGTTAAAATTTTAGAAACTGGCAACACTGATTAA
Protein Sequence
MILKLKTNHIVIQKYMNILSEQVKQSPNTESQEEKELVLTIDNVNSLNVPTTVSKIPKETNNVTQIFLCDVDTKNIVVWDKNSQDVLKYKCPYCNKKFAYHRSIINHRNKHKDEFYRCTNCTELFKGFKDLMRHRKVVHSERISTCDICRIILLNEDCEHKKGLICELCQISFNSKTELVNHNKKHLKSLHNFENTDCSECKDECIHKPYLNWFNAQQLANKITFQCLTCNVEHTTKDELITHVNEEHLQHSSYLCELCGQSFSSQLLLSKHIGCHETESVIKKTRVYIPIPLKTFECKLCGYCFFNEKFYRAHRRKHMSGENECQYCQRLFYNINRLNMHIAKDHKNENPNNMFYKCSMCTSDFDSRKEYLKHITTHPKDSKHICRVCKASCTSKRSYLLHVKSHKQTYDRECPVCFKMYTLQTIQRHMKTHLKENWKDGGGPKACDICGQLLLSDKGLIKHSKTHKEEQQCPYCHKCVKVIFFNEHLNTHSEKHRTIKQCQQCDYTTRFSPCLQAHVNRFHLKSRPFQCTVCNKTFYSEYTLKGHQVVHNDTRQEHFCEMCGKKFISTKALMLHMRLHTGETPYPCDLCKLSFLSSSRRRQHMIRKHFEPSIACDICHKKMYTQSDLKRHMTKCAGKETIVKILETGNTD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-