Basic Information

Gene Symbol
-
Assembly
GCA_950371115.1
Location
OX493351.1:2338576-2342941[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 0.0011 0.11 14.0 3.7 1 23 164 187 164 187 0.97
2 17 0.00029 0.028 15.9 3.0 1 23 196 219 196 219 0.96
3 17 0.019 1.9 10.1 0.3 2 23 232 254 232 254 0.97
4 17 0.025 2.5 9.8 1.9 1 23 263 286 263 286 0.94
5 17 9.9e-05 0.0096 17.4 1.6 1 23 298 321 298 321 0.97
6 17 6.5e-05 0.0063 17.9 0.3 3 23 350 371 349 371 0.97
7 17 0.0015 0.15 13.6 1.2 2 23 381 403 380 403 0.96
8 17 0.026 2.5 9.7 0.7 2 19 408 425 407 428 0.93
9 17 0.0018 0.17 13.4 0.5 2 21 433 452 432 455 0.94
10 17 0.059 5.7 8.6 0.9 2 23 464 486 464 486 0.94
11 17 4.7e-05 0.0045 18.4 2.3 1 23 491 514 491 514 0.96
12 17 0.00089 0.086 14.4 2.6 2 23 526 548 525 548 0.95
13 17 0.51 49 5.7 1.0 1 23 571 594 571 594 0.91
14 17 0.0049 0.48 12.0 0.1 2 23 601 622 600 622 0.97
15 17 0.0089 0.86 11.2 0.8 2 23 628 649 627 649 0.97
16 17 0.021 2 10.0 0.1 1 23 715 737 715 737 0.97
17 17 0.21 21 6.9 2.0 1 23 743 766 743 766 0.96

Sequence Information

Coding Sequence
ATGGCGACACTAAAAGAAGATGCAgatgtaaaaataaagatagaATATGACCATGAAAAGGATGGATGGAAAGTAAAAAAAGACAAAGAAGAAAAAGAGCGAAAAGACCCAACTTCGTTCTTACCCGAAGAGCCAATGTCCTACGAAATCAaggagaaaaagaaaaaaaagaagaaaaagaaacagGAGGACCCGTTTAAAGACTTAGAGCTCAAGAAACAGGATTATGTCACAGAACCATCATTAGAATTACAGTTAGATCCGGAAGTTAATATAAAAGTGGAAAACATAGAAGTTGAGTTGGATTTCAATGATTTTGCCGACCAATTGGAAGGTCCTCAAAGCGAAGAAAGCCAGGAGCCAATAGTCAAACTCGAAGAGCAAAACCGCGAAGCAGTTTTACTAACTTTTGAGAGTGTCGTCAATGAACACTCAGTATTTGGAGTAAAGGAGGAAAATTTAGACGTTAGTGCAAAAGTTGCATCTACCTTTATGTGCAAAGTCTGCCATCTAGTCTTTCAATCGGCGAAAACCTTGCGAATGCACcagaaaagaaaacataaatcaTACAGACAATCTTTCAAACACATCTGTGATCATTGCAGCATGTCGTACGAGACTAAGAATAGTCTTATAGCTCATATTAGGAGAAAGCATGGCCCTGATTCGACACCAGAAGACAAAGAGGAAAGAACTTGCGAGATTTGCGCTTTGGTTTTCAAAGGAATAGCCAGATTGAGGATGCATATGCGGAGGAAACATGGCTCGTTCGAAGACTCCTTCAAACATGCTTGCACCGTTTGCGGATTGACATACGACAAGTACAGGAGCTTAATGGTGCATTTCCAACGTAAACATACCAATACTAAGAAGCCTATAGAAAACCAATGGTACAAGTGTCCGTTTTGTGCCAAAATCTTCACCAGGAGAGAGACATATGCCCGGCATGTGCAAAGAAAGCATAAAGTGACGAAAGAAGATGCTCAGAAGGAAGATATGCCGATTTATTTGGAAAATTGCAAGAACGAACAAACGGGAGAGGTCGCTTGCAAAGAATGCCCTCTCGTGTTCTCCTCGATAGGTTATTTAAAGCTGCATATGAGGAGAAAGCATAACGCACTAAAAGAAGACTTCAGATTGAAGTGTAGGATTTGCAATTTGTCGTACGATAAAATAGAAAGCCTTAAACGGCATGTGAGGAGAAAACACGATCAAGGATCGTACTGCGaagtgtgcaataaacaatttgaaacaAGAGAGTCGTATTTAAACCATTCCCATGTTAGGGCTATTAAGGAATGCTCATTATGCGGGCTAATTTTCGCGTCGCAAGGCGGGTTAGCAAAACATATAAGGTGCACGCACAAAATAGACTCCCCAAAGGTTGCCTACTGCAATATTTGCAACGAAGGGTTCCACGACAGACGCTTGCTCAAACCGCATTTACTAAAAGTGCATTTAAAGGTGTCGTACACCTGTAAATATTGCAAGAAAGTCTTTAAAGCTAAAGAGAGTTATAGACGCCATGTGATTATAAAACATCCATCAAATAATGCTTTCAATGTTCAAAAGCAGCAATGCGAGCACTGCTCAGAGATGTTCAACGATGAATTCGAGTTGTGTAAACATATAAACCTCATTCATGGCAAATATGAGAGTTTACCTTTAGACGTAGATGTCAAAATTGAGGATTCAGATATGAAAAATAACTACCAGTGCACAAAATGTTCGGATATTTATCCGAATTTCGAACAACTCAAGTTGCATTTCGAACAGAACCACCACTTTTCTGAAGAGACTCAGTGCCAAATGTGCGGGGAAATGGTACCCGCTTCGGAATTACAAAAGCATATAAAAACTCTGCACACAGAGATATCGGTACAGTGCAAGTACTGCGAATTTGAGACGACAAATAAAGCTAGTATGACACAGCATGTCTTGAGACACAAAAACGCTACAACACTGCACTGTGATTTCGCTGGGTGTAGATACAAAAGTTACTATGACGTGGCCATGCACAAACATAAGCAAAAGCATAAAGAATTAGGTGTTAAGCTTCAATGTTCTTCGTGTTCGTTCCAAACGATGAATAAATACATTCTGAAGTACCATGAGGAAGCCCATGTAACGGGGAAGAAACGGTACATGTGTGATCAATGTGATTATGCTACCATACTACCGGCTAATTTAGTACAGCATAAATATAAGCACTCAACAGAAAAGAGGTTTAAGTGTGAGGTTTGCCCGTTCGCAACGAAGTACAATACGTCTTTGCGTTTCCATGTTAAAAAGAAACACTGTGATTTACCAAGTTTCAGTTGA
Protein Sequence
MATLKEDADVKIKIEYDHEKDGWKVKKDKEEKERKDPTSFLPEEPMSYEIKEKKKKKKKKKQEDPFKDLELKKQDYVTEPSLELQLDPEVNIKVENIEVELDFNDFADQLEGPQSEESQEPIVKLEEQNREAVLLTFESVVNEHSVFGVKEENLDVSAKVASTFMCKVCHLVFQSAKTLRMHQKRKHKSYRQSFKHICDHCSMSYETKNSLIAHIRRKHGPDSTPEDKEERTCEICALVFKGIARLRMHMRRKHGSFEDSFKHACTVCGLTYDKYRSLMVHFQRKHTNTKKPIENQWYKCPFCAKIFTRRETYARHVQRKHKVTKEDAQKEDMPIYLENCKNEQTGEVACKECPLVFSSIGYLKLHMRRKHNALKEDFRLKCRICNLSYDKIESLKRHVRRKHDQGSYCEVCNKQFETRESYLNHSHVRAIKECSLCGLIFASQGGLAKHIRCTHKIDSPKVAYCNICNEGFHDRRLLKPHLLKVHLKVSYTCKYCKKVFKAKESYRRHVIIKHPSNNAFNVQKQQCEHCSEMFNDEFELCKHINLIHGKYESLPLDVDVKIEDSDMKNNYQCTKCSDIYPNFEQLKLHFEQNHHFSEETQCQMCGEMVPASELQKHIKTLHTEISVQCKYCEFETTNKASMTQHVLRHKNATTLHCDFAGCRYKSYYDVAMHKHKQKHKELGVKLQCSSCSFQTMNKYILKYHEEAHVTGKKRYMCDQCDYATILPANLVQHKYKHSTEKRFKCEVCPFATKYNTSLRFHVKKKHCDLPSFS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00074811;
90% Identity
iTF_00076851;
80% Identity
-