Basic Information

Gene Symbol
topi
Assembly
GCA_949315895.1
Location
OX438876.1:9362314-9387100[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.0007 0.077 14.7 1.2 1 23 201 223 201 223 0.98
2 12 0.0091 1 11.2 2.8 1 23 230 253 230 253 0.97
3 12 6.5 7.2e+02 2.3 4.5 1 23 257 279 257 279 0.93
4 12 0.029 3.2 9.6 4.7 1 23 284 306 284 307 0.95
5 12 0.0028 0.31 12.8 0.6 1 23 311 334 311 334 0.96
6 12 0.00062 0.069 14.9 0.2 2 21 347 366 346 367 0.94
7 12 0.0057 0.63 11.9 0.1 3 23 380 400 379 400 0.96
8 12 0.0014 0.15 13.8 0.6 2 23 407 429 406 429 0.96
9 12 1.6e-05 0.0017 19.9 1.1 2 23 449 470 448 470 0.97
10 12 2.5e-05 0.0028 19.3 0.4 1 23 476 498 476 498 0.98
11 12 1.3e-05 0.0014 20.2 1.5 1 23 504 526 504 526 0.94
12 12 1.7e-07 1.9e-05 26.1 1.8 1 23 532 555 532 555 0.97

Sequence Information

Coding Sequence
ATGGCGGAAACGCTAGCTTGTCGTCTGTGTTTATCAACAAATATAAAACTCTTCAATATGTTCAAGTTTCGTCTTCATACAGCTTATACGAGTCTCACTGGAGTTGAGATGGCCATCTCAGATGGGCTCCCACCGTATGCCTGCGGTGTTTGCAGCACCCTCCTCATCAAGAGCTTATCCTTTAAGCGAATGTGCGACAATTCACACGATATACTCAAGTTTGCGTTAACACAGCGATCGttGTCTACAGACTACATTCAGAATCTAAAAGTCACTTCACCGTTTGCCTTCTCAATAAAATCCAACGAGCCAATGGATTGTGTCTACGAGCCAGATGTCAAAGATGAAATATGGGACTGGGCCATCGAAGAATACAAGGTGGAAGAAAACGAATCCAGCGATGAGGAGCCATTGTcaagtaagataaaaaaaagcgAAACAGAACTAACGGTTAAAGATGAAGGGCTCACGGAATTTCCAGAAACACAGGATGATGAGGATTTTCCTAACGAAGAAGTGAGAGAGATAGTGTTAACAAAAGAAGAGCAAATAGAAGAGGTTCAATCGAGGAAGACATCGATGAACTATCTGAACTCTTTTTACAAGTGCGACAGATGTTATAAAGGTTTTATAACAGATGCAACTTATAAGAATCATATGGCCCGGCATGATCCAAATAGCGGTACCCACGAGTGTGACATATGCCACATAAGACTCTCGCATATGCGCGCCCTCCGCGCCCACGTCATGACCTCCCATGAGAGGAAGTTTGTGTGCAAACTGTGCAACCATGTTTCCAAGTCTAGACACAGAGCGAAGGAACATTCAAAATGGCACAGCGGCCATACGTTCGTGTGTAAATTCTGCGGAGCTTCTTTCACCAAATCCACGAGTCATCTAACCCACATACGCTTGCATCACCCATCGAAGCACACTTGCTTCGTTTGCGGCGAGTCGTTCATAGGCGAGAACGGGCTGAACATGCACAAGAAGAAGGCGCACAGAGATGTGAAGAATTCCGAATCGGATTCGGAGACACGATGCAACAATTGTGACGTGCAATTCAACAACGCGGACGCTTTGAGAAGGCACACGAAAGATTCGGAAGACCTTAAGTGCGATGATAGTTTGAGGCCTTGTACGCAGTGCGGCGAGAGCTGGTCTACGGAAGACGAACTAAAAGAACATCTGAAAGCCCATTCTAAAGACGAACCAGTCAAGTGCGAAGAGTGTAACCGAATATTCGCTCACGAGCGTTCGTACGCGGTGCACTACCAAAGGGTGCACTTGCGTGTCCGCGCGTCCAAAAAGGACGCCCACGGTAGGGCGAGGCGCGCGTCCGTCGTGTGCGAAATATGCGGCCGCAAGTGTATTTCGAACGCGTCTCTACGCTACCATCAGCGAACGCACACGGGCGAGAGGCCGTACGCTTGCACCGAGTGCCCGAAGAGGTTCAGCATCGCGCAGAGGCTACAGATACACCAACGGACACACACAGGCGAACGACCTTACAAGTGCAGCCTCTGCCCGAAAGCCTTCAAGCATAAGGCAGCGCTGAACAGGCATGATAGGGTACACACTGGGGCGAAGCCCTACGCCTGCTCCCACTGCGGTAAGTCCTTCTCACAGTCAAACTCAATGAAAGTGCACATACGCACTGTTCACCTGAAGCTGCCTTCGCCGTACAGAGCTCGAAGAACAGTCGAGTGA
Protein Sequence
MAETLACRLCLSTNIKLFNMFKFRLHTAYTSLTGVEMAISDGLPPYACGVCSTLLIKSLSFKRMCDNSHDILKFALTQRSLSTDYIQNLKVTSPFAFSIKSNEPMDCVYEPDVKDEIWDWAIEEYKVEENESSDEEPLSSKIKKSETELTVKDEGLTEFPETQDDEDFPNEEVREIVLTKEEQIEEVQSRKTSMNYLNSFYKCDRCYKGFITDATYKNHMARHDPNSGTHECDICHIRLSHMRALRAHVMTSHERKFVCKLCNHVSKSRHRAKEHSKWHSGHTFVCKFCGASFTKSTSHLTHIRLHHPSKHTCFVCGESFIGENGLNMHKKKAHRDVKNSESDSETRCNNCDVQFNNADALRRHTKDSEDLKCDDSLRPCTQCGESWSTEDELKEHLKAHSKDEPVKCEECNRIFAHERSYAVHYQRVHLRVRASKKDAHGRARRASVVCEICGRKCISNASLRYHQRTHTGERPYACTECPKRFSIAQRLQIHQRTHTGERPYKCSLCPKAFKHKAALNRHDRVHTGAKPYACSHCGKSFSQSNSMKVHIRTVHLKLPSPYRARRTVE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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