Basic Information

Gene Symbol
-
Assembly
GCA_032362555.1
Location
CM063575.1:5458909-5460399[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.00017 0.012 16.7 1.9 1 23 133 156 133 156 0.95
2 10 0.0011 0.073 14.2 4.4 3 23 165 186 164 186 0.96
3 10 0.37 24 6.2 5.4 2 23 194 216 193 216 0.95
4 10 9.7e-06 0.00065 20.6 0.1 2 23 224 246 223 246 0.96
5 10 0.00028 0.019 16.0 4.9 1 23 253 276 253 276 0.96
6 10 0.0017 0.11 13.6 5.8 1 23 282 305 282 305 0.94
7 10 9e-05 0.006 17.6 0.3 2 23 313 334 312 334 0.97
8 10 0.0028 0.18 12.9 2.2 2 23 342 364 341 364 0.96
9 10 0.00022 0.015 16.3 3.5 2 23 371 393 370 393 0.94
10 10 4.4e-05 0.003 18.6 3.7 1 23 403 425 403 425 0.98

Sequence Information

Coding Sequence
ATGGACATGACGGACCACGGCATGGCGGGGATGAACCTCACGATGGACGGCATGGACTACAAAATTGACGGCGGCATGAAGATGGAGGGAGCGGATGTGTCCCAACAGGGATCTATGTCCTCCATGTCACAATTCCCAACTTTGAACCTCCTCCCGCCACTGCCACCACATCTGGTGCAATCGGAATACGCTCCGCTGCCGGAAAATTTGCCAAAAACTGAACCCACCACGGTCCCAGAACTCCCGTCTTTACCAGTTCACATGACGCAATCCGAGTCAAAACCTACCAAGTATATAAGCGTGACAAGCGACGAGTTGACCGACGAACAGAGGCAGATGTACGAGTCCGTACTCTCTACGTGGAAACCGGTGTTGTTCCCCAAAACAGTGAAACGTTACATCTGCGAGAAATGCAACAAGGAGTTTAAGAATTACCAAAACCTCTATTTGCACACCACTCGGGTCCATTCTACTGAAGATTCTGCCGTCTTGTGCGACAGATGCGACAAGTCGTTCAAGAATAAGCATTATCTGTACATGCACAGAATGAATAAGCATTATTCGGAGTCGGAGAAATGTTATTGTCAGTTCTGCCTGCAGGAGTTTCGCACGAGACGCGCTTTACACATGCACGTGAAGAAGGTTCATCCCAACACGCTCCCAGAGATCAAATGCCCCGAGTGCGGCAAAGAGTTCAACGTGCCCTACAAATTGAAGTATCACATCGAACGCGTACATCGCGCAGACAGAGAAAAGTACAAATGCCATCTCTGccaaaaattgtacaaaagCAATTTGAATCTGAACAGGCACATGCAGTTCCAACATTCACACGTCGAAAGACACCCGTGCGTGTTCTGCGACATGACGTTCAAGTCTCGTCATCACATGAAACGCCACATCCTGAACATTCACCCGCCGTTGGAGTCCAAGGTGACGTGTCCGGAATGCCTGAAGGAGTTCAAAAACGATCAGTATCTTAAAGAGCACATGCAAATCCACACGCCAGCCGACACGAAGGTCAAATGCGAGTTGTGCGACAAGTTTTTCCATTCGGCGATACGCCTCAAAAAGCACAAGAAGATCGTCCATCCGTCGAAGCCTAAGATTCGTTGTGAGAAATGCAACAAAGAGTTCGCGCACGCGCATTATTTGCGGCGTCACAACAACTCTGTCCACGTGGACGTTGACGAGAAAAACTATGAGCACCAATGCGGGCTGTGCGGCAAGAAGTTCAAGTTGCAACGTTATTTGAACAATCACTTGCAGAGACATGAACAACAGCATTTGAAGAGGATCTCGCAGATGGTCAAGACAGTCATGAATGAGGACGGCAAGGAGGTGAAGGTGAAGCAGCGGGGGAGGCCGAAGGGTAAGAAGAATTCTAAAAAGGTAACGAAGGAGATCGAGTTCATCAAGTGTGAACCTGTGTCGAGTTCGGAATCCGAAACTGAGGAGTCGAGCGAAGAGGAATCTGACGAGTCGGAGTAA
Protein Sequence
MDMTDHGMAGMNLTMDGMDYKIDGGMKMEGADVSQQGSMSSMSQFPTLNLLPPLPPHLVQSEYAPLPENLPKTEPTTVPELPSLPVHMTQSESKPTKYISVTSDELTDEQRQMYESVLSTWKPVLFPKTVKRYICEKCNKEFKNYQNLYLHTTRVHSTEDSAVLCDRCDKSFKNKHYLYMHRMNKHYSESEKCYCQFCLQEFRTRRALHMHVKKVHPNTLPEIKCPECGKEFNVPYKLKYHIERVHRADREKYKCHLCQKLYKSNLNLNRHMQFQHSHVERHPCVFCDMTFKSRHHMKRHILNIHPPLESKVTCPECLKEFKNDQYLKEHMQIHTPADTKVKCELCDKFFHSAIRLKKHKKIVHPSKPKIRCEKCNKEFAHAHYLRRHNNSVHVDVDEKNYEHQCGLCGKKFKLQRYLNNHLQRHEQQHLKRISQMVKTVMNEDGKEVKVKQRGRPKGKKNSKKVTKEIEFIKCEPVSSSESETEESSEEESDESE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00652061;
90% Identity
-
80% Identity
-