Aaes003252.1
Basic Information
- Insect
- Alsophila aescularia
- Gene Symbol
- -
- Assembly
- GCA_946251895.1
- Location
- CAMIUG010000116.1:100103-101578[+]
Transcription Factor Domain
- TF Family
- Nrf1
- Domain
- Nrf1_DNA-bind domain
- PFAM
- PF10491
- TF Group
- Basic Domians group
- Description
- In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human [1]. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila [2]. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0 there is also an NLS domain at 88-116, and a DNA binding and dimerisation domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 2.4e-10 2.9e-06 28.1 0.0 115 208 5 91 1 95 0.84 2 2 0.37 4.4e+03 -1.9 0.0 111 147 315 351 297 356 0.69
Sequence Information
- Coding Sequence
- ATGATCGCCATCCTGCCGCTACTCTTTGCCAACGGGCACCCAGTGGCGCTCACCAACTTCACCGCGTCCGAGTTGGAGAAGTTCATAACTTTCATGGTGACTTGTTCCTGGGGGCACGACACGGCGAGCGCCATCCTGCAGCCGCCATGGTGGCCGAAGGACGTCCCGTTCTCACACCCGTTCACTCGGCCCGCCTCCGTGCCCAAGGACTGGGAGGAGAAGCTGAAGAAAGTGGTGCGGAAGTGCTACGAGTTCCACAAGAGCACCTTCCTGATGGTGTTCTCTGCGCAGCTCGCGCGCCACCCGCGTCACAAGCTTCGCTACGTCGACAACCGCGACCACACCACCTCTCTCTATGACAAACCCAACGGCAAGCTCCTCGTTACCTTCAGAAACGAGAACCTCTATTATGACGCTAAACCTATATTATTGGATGATGATGATGAAGAAACTCAAGTGAAGACTTCTGATATTTATCTATGTGACAATTGCGACAGCCACTTTGACAACTTGGAAGTTCTGAAAGCTCATGAGAGGCTCTGTAATAATGAAGTTACTCCATCAACTTCTTGTACCGGAGGACTGCCAGATTTTCTGTCAGCTCTTAAGCTGATACCGGTTGGAGCAAATGCGATGGAATCTGTGTGTTTCAACTCTAGTAGTGAATCTAAATCTAAAATTGTGCGAAGTGCAGCCAACATTGACAGGGGACCACCATATCCATTTTCATCTCTGGCTTATCAGAGAAATATAAAAACGAATGTCCAGAGAGACTCAACATACACTAGGGAGCGAGTGGAGAGATACTGCTGCACAAACACACTTCCTAGCAAAGTTTTAGTTAAGGCTAAAAATCAATTTCCCGTGAGATACAGGCGGCCTATAGATTACTGGCATCGCAAACATGTATTTCCAAATCAAAGAAAAAAGAAAATACTCGATGTGAAAGGACAGCTGCTGATGCTGAAGTGTAGACCCATCACTGTCCACGTTGACAGAATGTCTAGCGAGAGCATGGATGAATATATAGAGAACTTGAAAAAGGAGGCAGAAAGAAAATCACAATTAATGGCAGATAAAGATATTGTATTTGTGGACCGATTAGATTGTGATCAGACAGAATTTGATGGTAAGAAGTTAGACCCGTTAAAACGTGCAGACAGTGAGTGTGAAGTAATTGATCTTTGTTCAGATGATGAGAGTCCTAGTGTGAACGAGAACTGTGATCCCCGAACAGGTGTGACATGTGTGATGAGAGGAGGTGCGGTGCTGCGACGCACGGCTGCCACGCCGCAGGTGCTGCCCTCGGAGCCCTGTGGAGCTCGGCAACGGCCTCTGCCGGCAGCTATACTCCAACCGCACCCCGTTATCTTAATTGCGCATACTCTAAACCATTTACAGACTATATCCTTAGAGTGA
- Protein Sequence
- MIAILPLLFANGHPVALTNFTASELEKFITFMVTCSWGHDTASAILQPPWWPKDVPFSHPFTRPASVPKDWEEKLKKVVRKCYEFHKSTFLMVFSAQLARHPRHKLRYVDNRDHTTSLYDKPNGKLLVTFRNENLYYDAKPILLDDDDEETQVKTSDIYLCDNCDSHFDNLEVLKAHERLCNNEVTPSTSCTGGLPDFLSALKLIPVGANAMESVCFNSSSESKSKIVRSAANIDRGPPYPFSSLAYQRNIKTNVQRDSTYTRERVERYCCTNTLPSKVLVKAKNQFPVRYRRPIDYWHRKHVFPNQRKKKILDVKGQLLMLKCRPITVHVDRMSSESMDEYIENLKKEAERKSQLMADKDIVFVDRLDCDQTEFDGKKLDPLKRADSECEVIDLCSDDESPSVNENCDPRTGVTCVMRGGAVLRRTAATPQVLPSEPCGARQRPLPAAILQPHPVILIAHTLNHLQTISLE
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00895655; iTF_01208938; iTF_01172066; iTF_01207845; iTF_00124909; iTF_00250195; iTF_00648847; iTF_00913343; iTF_00390099; iTF_00818100; iTF_00649751;
- 90% Identity
- -
- 80% Identity
- -