Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 9.3e-06 0.00032 23.6 1.2 1 23 10 32 10 32 0.98

2 7 0.00036 0.012 18.6 0.9 1 23 38 60 38 60 0.97

3 7 0.00023 0.008 19.2 1.0 1 23 66 88 66 88 0.97

4 7 9.8e-05 0.0034 20.3 1.2 1 23 94 117 94 117 0.95

5 7 0.00038 0.013 18.5 1.3 1 23 122 145 122 145 0.96

6 7 0.047 1.7 11.9 3.7 5 23 155 173 152 173 0.96

7 7 0.22 7.6 9.8 5.7 1 23 180 202 180 203 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	9.3e-06	0.00032	23.6	1.2	1	23	10	32	10	32	0.98
2	7	0.00036	0.012	18.6	0.9	1	23	38	60	38	60	0.97
3	7	0.00023	0.008	19.2	1.0	1	23	66	88	66	88	0.97
4	7	9.8e-05	0.0034	20.3	1.2	1	23	94	117	94	117	0.95
5	7	0.00038	0.013	18.5	1.3	1	23	122	145	122	145	0.96
6	7	0.047	1.7	11.9	3.7	5	23	155	173	152	173	0.96
7	7	0.22	7.6	9.8	5.7	1	23	180	202	180	203	0.95

Coding Sequence: ATGAGAATTCACAGGAATATTCGTCCGTTCTCTTGTTCAATGTGTGACAAGTCCTTTGTTCAGAGCGGCAATATGAAGACTCATGAAAAAATGCACTACAGAGATAAGCCATTTCCCTGCAGCTTATGTCCGATGAGGTTCAGAACTAAGAAAGATATATCGAGACATATGGTAAAACACTCCGACATTTATAAATACAGCTGCGATCAATGTGGGAAAGAATTCAAGTACAAAAATGTGTACAATCAACACATGGCGCTGCATGAAAACTCAGACGCGTTTTCCTGCGACACTTGTTCTAAAGTGTTTAGTTCGAGTACAGCATTGGTTCGCCATAAGAAAGGAAAGCATGAACAAAAAATATTCTCATGTGATCAGTGTGATAAAAAGGTGTCCAGTGCTGATGCACTCAGAAGCCACAAAAGACACGTCCACCCGACCGAGACCAAGACGTACGAGTGCGAGTGCGGGGCACAGTTTACGCACAAACTCTACCTTCGGCATCATCTCAAAACTCATTTGTCTCGTCGTGTATCTTTCCACTGTGATCTCTGTAGTAGAAGTTATTTGTCCAAGTATAACCTAGCAATACACAAGAAGAAACATCACTAA
Protein Sequence: MRIHRNIRPFSCSMCDKSFVQSGNMKTHEKMHYRDKPFPCSLCPMRFRTKKDISRHMVKHSDIYKYSCDQCGKEFKYKNVYNQHMALHENSDAFSCDTCSKVFSSSTALVRHKKGKHEQKIFSCDQCDKKVSSADALRSHKRHVHPTETKTYECECGAQFTHKLYLRHHLKTHLSRRVSFHCDLCSRSYLSKYNLAIHKKKHH

Sequence clustering based on sequence similarity using MMseqs2