Basic Information

Gene Symbol
TFAP2A
Assembly
GCA_963675035.1
Location
OY776114.1:34841349-34850566[-]

Transcription Factor Domain

TF Family
AP-2
Domain
TF_AP-2 domain
PFAM
PF03299
TF Group
Basic Domians group
Description
Activator protein-2 (AP-2) transcription factors constitute a family of closely related and evolutionarily conserved proteins that bind to the DNA consensus sequence GCCNNNGGC and stimulate target gene transcription [PMID: 2010091, PMID: 1998122]. Four different isoforms of AP-2 have been identified in mammals, termed AP-2 alpha, beta, gamma and delta. Each family member shares a common structure, possessing a proline/glutamine-rich domain in the N-terminal region, which is responsible for transcriptional activation [PMID: 2010091], and a helix-span-helix domain in the C-terminal region, which mediates dimerisation and site-specific DNA binding [PMID: 199812]. http://www.ebi.ac.uk/interpro/entry/IPR013854
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 1.9e-12 1.2e-07 34.5 0.0 78 120 164 206 159 217 0.88
2 13 5.9e-12 3.5e-07 33.0 0.0 85 120 242 277 229 288 0.92
3 13 5.9e-12 3.5e-07 33.0 0.0 85 120 313 348 300 359 0.92
4 13 5.9e-12 3.5e-07 33.0 0.0 85 120 384 419 371 430 0.92
5 13 3.6e-11 2.2e-06 30.4 0.0 85 120 455 490 442 501 0.92
6 13 9.5e-12 5.7e-07 32.3 0.0 85 120 526 561 515 563 0.93
7 13 3.2e-07 0.019 17.5 0.0 92 120 563 591 561 593 0.92
8 13 4.1e-07 0.025 17.1 0.0 92 120 593 621 591 623 0.92
9 13 4.4e-07 0.026 17.1 0.0 92 120 623 651 622 653 0.92
10 13 2.7e-07 0.016 17.8 0.0 92 120 653 681 651 691 0.90
11 13 4.9e-12 2.9e-07 33.2 0.0 85 120 717 752 712 763 0.91
12 13 5.9e-12 3.5e-07 33.0 0.0 85 120 788 823 775 834 0.92
13 13 2e-35 1.2e-30 109.6 0.0 85 196 859 969 854 970 0.96

Sequence Information

Coding Sequence
atgacgatctcggtggtgaccagGCGAACCACTCGTGGCGCTGCCTTGGGATCGCAACCCGTTGGCTCCCTTCAAGGCGTCCCACTCGTGGCGCTGCCATGGGATCGCAACCCGCTGGCTCCCTTCAAGGCGTCCCACTCGTGGCGCTGCCATGGGATCGCAACCCGCTGGCTCCCTTCAAGGCGTCCCACTCGTGGCGCTGCCATGGGATCGCAACCCGCTGGCTCCCCTCAAGGCGAACCACTCGTGGCGCTGCCTTGGGATCGCAACCCGCTGGCTCCCTTCAAGGCGTCCCACTCGTGGCGCTGCCTTGGGATCGCAACCCGCTGGCTCCCTTCAAGGCGAACCACTCGTGGCGCTGCCTTGGGATCGCAACCCGCTGGCTCCCTTCAAGGCGTCCCACTCGTGGCGCTGCCTTGGGATCGCAACCCGCTGGCTCCCTTCAAGGCAACCCACTCGTGGCGCTGCCATGGGATCGCAATCGCCTGTCTATTCCAATCGGCATTCTGCAGAGAGGCGATCCACCTGGCCAGAGACTTCGGCTATGTCTGCGAGACCGAGTTCCCCGCAAGGCAAGTGGCCGAGTACCTGAGTCGCCAACACACCAACGACCCCACTGAGACATACCCTCACGATCAATGTGTCTTTTCTTTGTTTAGGAGAGGCGATCCACCTGGCCAGAGACTTCGGCTACGTCTGCGAGACCGAGTTCCCCGCAAGGCAAGAGAGGCGATCCACCTGGCCAGAGACTTCGGCTACGTCTGCGAGACCGAGTTCCCCGCAAGGCAAGTGGCCGAGTACCTGAGTCGCCAACACACCAACGACCCCACTGAAACATACCCTCACGATCAATGTGTCTTTTCTTTGTTTAGGAGAGGCGATCCACCTGGCCAGAGACTTCGGCTACGTCTGCGAGACCGAGTTCCCCGCAAGGCAAGAGAGGCGATCCACCTGGCCAGAGACTTCGGCTACGTCTGCGAGACCGAGTTCCCCGCAAGGCAAGTGGCCGAGTACCTGAGTCGCCAACACACCAACGACCCCACTGAGACATACCCTCACGATCAATGTGTCTTTTCTTTGTTTAGGAGAGGCGATCCACCTGGCCAGAGACTTCGGCTACGTCTGCGAGACCGAGTTCCCCGCAAGGCAAGAGAGGCGATCCACCTGGCCAGAGACTTCGGCTACGTCTGCGAGACCGAGTTCCCCGCAAGGCAAGTGGCCGAGTACCTGAGTCGCCAACACACCAACGACCCCACTGAGACATACCCTCACGATCAATGTGTCTTTTCTTTGTTTAGGAGAGGCGATCCACCTGGCCAGAGACTTCGGCTACGTCTGCGAGACCGAGTTCCCCGCAAGGCAAGAGAGGCGATCCACCTGGGCAGAGACTTCGGCTATGTCTGCGAGTCCGAGTTCCCCGCAAGGCAAGTGGCCGAGTACCTGAGTCGCCAACACACCAACGACCCCACTGAGACATACCCTCACGATCAATGTGTCTTTTCTTTGTTTAGGAGAGGCGATCCACCTGGCCAGAGACTTCGGCTACGTCTGCGAGACCGAGTTCCCCGCAAGGCAAGAGAGGCGATCCACCTGGCCAGAGACTTCGGCTACGTCTGCGAGACCGAGTTCCCCGCAAGGCAAGTGGCCGAGTACCTGAGTCGCCAACACACCAACGACCCCACTGAGACAGACTTCAGCTACGTCTGCGAGACCGAGTTCCCCGCAAGGCAAGTGGCCGAGTACCTGAGTCGCCAACACACCAACGACCCCACTGAGACAGACTTCGGCTACGTCTGCGAGACCGAGTTCCCCGCAAGGCAAGTGGCCGAGTACCTGAGTCGCCAACACACCAACGACCCCACTGAGACAGACTTCGGCTACGTCTGCGAGACCGAGTTCCCCGCAAGGCAAGTGGCCGAGTACCTGAGTCGCCAACACACCAACGACCCCACTGAGACAGACTTCGGCTACGTCTGCGAGACCGAGTTCCCCGCAAGGCAAGTGGCCGAGTACCTGAGTCGCCAACACACCAACGACCCCACTGAGACGTACCCTCACGATCAATGTGTCTTTTCTTTGTTTAGGAGAGGCGATCCACCTGGCCAGAGACTTCGGCTATGTCTGCGAGACCGAGTTCCCCGCAAGGCAAGAGAGGCGATCCACCTGGCCAGAGACTTCGGCTACGTCTGCGAGACCGAGTTCCCCGCAAGGCAAGTGGCCGAGTACCTGAGTCGCCAACACACCAACGACCCCTCTGAGACGTACCCTCACGATCAATGTGTCTTTTCTTTGTTTAGGAGAGGCGATCCACCTGGCCAGAGACTTCGGCTACGTCTGCGAGACCGAGTTCCCCGCAAGGCAAGAGAGGCGATCCACCTGGCCAGAGACTTCGGCTACGTCTGCGAGACCGAGTTCCCCGCAAGGCAAGTGGCCGAGTACCTGAGTCGCCAACACACCAACGACCCCACTGAGACGTACCCTCACGATCAATGTGTCTTTTCTTTGTTTAGGAGAGGCGATCCACCTGGCCAGAGACTTCGGCTATGTCTGCGAGACCGAGTTCCCCGCAAGGCAAGAGAGGCGATCCACCTGGCCAGAGACTTCGGCTATGTCTGCGAGACCGAGTTCCCCGCAAGGCAAGTGGCCGAGTACCTGAGTCGCCAACACACCAACGACCCCACTGAGACGTACCGCCGCAAGGAGCTCATCCACGCTACCAAACAAGTGACGAAGGAGCTGATGGACCTGCTGAACCAGGACCGCTCGCCGCTGTGTAACACCCGACCGCAGCACATCCTCGAGCCCAGCATACAGCGGCACCTCACGCACTTCTCCCTCATCTCCCATGGCTTCGGCAGCCCGGCCATCGTGGCCGCCCTCACCGCCATACAGAACTTCCTGTCGGAATCGCTGAAGCACCTGGAAAAGGTTTACCCCTCAGGGAACAGTCTGGCAGTGACCTCCTCACAGCAGGGAGGCCCCGTCCTCTCCGATACCAAGCCCAAGGACCTGGGGTCCGAGCTGAAGAAGTGA
Protein Sequence
MTISVVTRRTTRGAALGSQPVGSLQGVPLVALPWDRNPLAPFKASHSWRCHGIATRWLPSRRPTRGAAMGSQPAGSPQGEPLVALPWDRNPLAPFKASHSWRCLGIATRWLPSRRTTRGAALGSQPAGSLQGVPLVALPWDRNPLAPFKATHSWRCHGIAIACLFQSAFCREAIHLARDFGYVCETEFPARQVAEYLSRQHTNDPTETYPHDQCVFSLFRRGDPPGQRLRLRLRDRVPRKAREAIHLARDFGYVCETEFPARQVAEYLSRQHTNDPTETYPHDQCVFSLFRRGDPPGQRLRLRLRDRVPRKAREAIHLARDFGYVCETEFPARQVAEYLSRQHTNDPTETYPHDQCVFSLFRRGDPPGQRLRLRLRDRVPRKAREAIHLARDFGYVCETEFPARQVAEYLSRQHTNDPTETYPHDQCVFSLFRRGDPPGQRLRLRLRDRVPRKAREAIHLGRDFGYVCESEFPARQVAEYLSRQHTNDPTETYPHDQCVFSLFRRGDPPGQRLRLRLRDRVPRKAREAIHLARDFGYVCETEFPARQVAEYLSRQHTNDPTETDFSYVCETEFPARQVAEYLSRQHTNDPTETDFGYVCETEFPARQVAEYLSRQHTNDPTETDFGYVCETEFPARQVAEYLSRQHTNDPTETDFGYVCETEFPARQVAEYLSRQHTNDPTETYPHDQCVFSLFRRGDPPGQRLRLCLRDRVPRKAREAIHLARDFGYVCETEFPARQVAEYLSRQHTNDPSETYPHDQCVFSLFRRGDPPGQRLRLRLRDRVPRKAREAIHLARDFGYVCETEFPARQVAEYLSRQHTNDPTETYPHDQCVFSLFRRGDPPGQRLRLCLRDRVPRKAREAIHLARDFGYVCETEFPARQVAEYLSRQHTNDPTETYRRKELIHATKQVTKELMDLLNQDRSPLCNTRPQHILEPSIQRHLTHFSLISHGFGSPAIVAALTAIQNFLSESLKHLEKVYPSGNSLAVTSSQQGGPVLSDTKPKDLGSELKK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-