Basic Information

Gene Symbol
-
Assembly
GCA_949125135.1
Location
OX421244.1:4570793-4576471[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 23 0.016 1.3 10.3 1.9 3 23 25 45 23 45 0.97
2 23 0.34 27 6.1 0.3 3 23 71 92 69 92 0.92
3 23 0.095 7.5 7.9 0.3 2 22 113 133 112 133 0.94
4 23 4.6e-06 0.00037 21.4 2.7 1 23 148 170 148 171 0.96
5 23 0.083 6.6 8.0 0.4 2 19 177 194 176 199 0.87
6 23 0.001 0.08 14.1 0.8 1 23 303 326 303 326 0.96
7 23 0.0089 0.71 11.1 0.0 2 23 402 424 401 424 0.92
8 23 0.0014 0.11 13.6 0.2 2 23 430 452 430 452 0.94
9 23 0.0031 0.25 12.5 2.0 2 23 457 479 456 479 0.95
10 23 0.047 3.7 8.8 0.4 1 23 484 507 484 507 0.96
11 23 0.00057 0.045 14.9 5.1 1 23 511 534 511 534 0.97
12 23 0.0024 0.19 12.9 0.1 2 23 541 562 540 562 0.95
13 23 3e-06 0.00024 22.0 0.7 2 23 569 590 568 590 0.93
14 23 2.6e-05 0.0021 19.1 1.3 1 23 596 619 596 619 0.95
15 23 0.15 12 7.3 4.7 1 23 680 702 680 702 0.98
16 23 1.4 1.1e+02 4.2 0.1 2 22 730 750 729 752 0.89
17 23 3.5e-05 0.0028 18.7 0.5 1 23 802 825 802 825 0.95
18 23 0.00076 0.06 14.5 5.9 1 23 828 851 828 851 0.97
19 23 0.11 8.8 7.7 1.2 1 23 857 880 857 880 0.95
20 23 0.0052 0.42 11.8 1.4 2 23 888 910 887 910 0.93
21 23 0.77 61 5.0 0.3 1 23 915 937 915 937 0.94
22 23 7.6e-07 6e-05 23.9 1.1 1 23 943 965 943 965 0.98
23 23 0.018 1.4 10.2 0.2 2 23 972 994 972 994 0.91

Sequence Information

Coding Sequence
ATGCGGAACAACTTAGAAGTATTGTTCAATCATACGACCATAATCCCTTTCAAGTGGAATACTAAGTACGGCTGCTTCTACTGCAACGAAACGTACACGGAATATGCAAAATTCAGAAAGCATACGAAGTCTCACGGACCTTGCtccaaaaatactttaaaacgCCTAAAAACGTGTCGAGAAGTTTTGATAGACGTGTCTGAAATCATTTGCGAGCTTTGCCACACTGAATTCAAAAGTCGTGCCGTCGTCGTTGATCATTTGATCAAGAGCCATCTTAAAGAATACGACAAGAATGTGGCCTTACGGTTTCAAGAGTATAGATTGAGTGATCTCAGATGTCTGTTTTGCGATCAGCAGTTTGGTAACTTTCAACTTTTGGCCCGACACGTGCGGCGGTGCGACGTGCGACATAGGCGTAGTTCTCAAACGGGTAATCGTTTTGTATGCAACGATTGCGGTAGGTGTTTTACGAAGGCTGCTAATATATCACTACATATAAGGACGCACCACGTTACAAAAGCGTTTGCTTGCATCAAGTGCAGTAAACAGTTCATTGATGAAGCAAATTTGAAGAAACATGATCTTCGTGAACATTTGCGACTATGTGCGCAATGCGATGCGAAATTTAAAAAGGAGGGTAATGGGGAGAAGTTTACTTCTAAAGAGCATTCCGACGAAACTGGCTCAAAATGCAGATATTGCTCGAAAGAGCTGCCTTCAGTTTCGGAAATGAAATACTATGTGCCTAGCAAACTTATAGACATGAACCAAGTCGATACCAATAATGACAACCAGCGCTTAAacaagagaataaaaaaaaacgctcACTGTAACCAAATTAGACGAAACATTCAATATGTTTTGAACACGTCCACAGCTGTGCCTTTTAAGTACAGAGGAAAGTTCTCCTGTTTCTATTGTACGCAACGGTTTCCCAATTTTGACGAACTGATTTCACATACTCGAGCGGAGCATCCGGTTTGCGAGCTGAATTCGAAGGCTATGCAGAGGTGTAAGGGCGAAAAGGCTCGTATTAAGCTGGATATAAATGGTCTAGCTTGCAAACTATGCCATCAATCCATGCCAGATCTGAAAAGCTTTGTAGACCACGCTATCGCTCAGCACGACGCGGAATATGACAAGTCTGTGCCGTTAAAAGACTGTTTCGACAGTTTCCACCTCACTCAAGGAGGCACGATTCCGTGTCCAGAATGTCAGGAACCGTTTGCGTATTTCGCAACATTGCTGAAGCACTTAGGCGTGGAGCACAACCATCACAAAGCGGTTTGCGCTTACTGCGGTCGAGGTTTCCGTTCTACTAACAGTTTAGCGATGCATATATCCTACTCTCACACAGGGACGTGTGAATGTAGCGTCTGCAACGCCAATTGCAAGAACTCCGCAGCTTTGGCGCGGCACATGGCTCGTTTCCACGACGCCAAAAACTTCAAGTGTCCCCAGTGTCCAGAGCTGTTTGAGACCATATACAAGAAGCAGAATCATTTGATTAAAGCCCATAACGTTGGACACAAATGTACGTATTGTGAGAAGATGTATACAAGGAATTCGTTCATGATGAATCATGTGAGGCGGACGCATTTGAAAGAACGGACCGTGCCTTGCTCGGTCTGCGGCGACAAGTTCTTCAGCCCTTATGATCTCAAATTACACATGGTGAAACACAACGGCGACAAAAAGATTGTCTGCAATGTGTGCGGTAAAAAATTCTCGAAGAAAAGCAACTTGAACACTCATACGGTTTTGCATACGAGGGAGAAGAATTTCTTTTGTCCTGTTTGCGATCGAGCGTTCGCTCATCAGACGACTTTGAAGGCTCACGTAAAAAACAGACATCAACCGTACGAGACCGAGTATAATATTCTTGATGATATGGCTAACAATGATATGGGCGAAGGCGTAACGAAGAGACAAATTCAAAATAGAGCCATCGACCGCCTCACCACTGTCCGAAGAAACATAAGCACCGTGCTTCGCCTCTCTAACGCCGTCCCCTTCAACTGGAATACCAAAGGCTTCCGATGCTTCTACTGCGCAAAATCTACCCAAGACTGTTATCTACTCAAAGAACACACTCTAAAACACAACGCGATAGATCTAGACGACTTTATAACCAAACACATTATTACCAAAGATGTCCCCATTAAAATAGACATAACTGACCTCGTGTGCAAAGTTTGCCAAAACCCGTCAGCCAATTTAGACGATTTCTTCGCGCATATTGTCGATAAACACGACGAAGAGTACGACGCTTCAGTAGGAGTGTGTTTCTTCCCATTTGTGTTGAACAAAGAAGTAATGCAATGTCTCCTATGCGAGAGTAATTACGATAATTTCGCGAGCATGGTCGGCCACATGTACAAGCAACATATCACTCATTCCTACATATGCCAGATTTGCGGCCTCAGCTTCAAAGACCAGATTCGTTTAAAGAGACACATAACAAACAGCCACGTCGGCTACAGATGCacaatttgcaaaaaaactTTCAGCGCTTTACACAAATTGACTAAACACAAGCAGAGGTTTCACGGGCAGGTGAAGCTGCACGAATGCAGCTTGTGCAGCGAGAAGTTCTTGAACAGTTATCAGGTTAAAGTCCACATGGGGAAGGTCCATAACGTGGAAAAGTATATGATAAAGTGCCAGCATTGCCCTAAGGTTTGCACGACGAAAGGGGCAATGCTACTTCATGTGCAGGGTCTTCATTCTGAGATTAGGTACCAGTGTGATTTGTGCGATTACACCGCCGGGATAAAGTGGCTGATTAAGCTTCATAAACGAAAGCATTTTGGCTTGAAAGATTACTCGTGTAGTATTTGCGAGCGGCAGTTCGGGCGGTCCAGTAATTTGAGGACGCATATGAAAGTGCACACGGGCAAAGTGGGCCGGGTCTGTCGAGTTTGTAGGAAAGGGTTCACGGATTTACAGTCTTATGAAAGGCACGAACTGGAGATTCATTATTATGATCACTTTTAA
Protein Sequence
MRNNLEVLFNHTTIIPFKWNTKYGCFYCNETYTEYAKFRKHTKSHGPCSKNTLKRLKTCREVLIDVSEIICELCHTEFKSRAVVVDHLIKSHLKEYDKNVALRFQEYRLSDLRCLFCDQQFGNFQLLARHVRRCDVRHRRSSQTGNRFVCNDCGRCFTKAANISLHIRTHHVTKAFACIKCSKQFIDEANLKKHDLREHLRLCAQCDAKFKKEGNGEKFTSKEHSDETGSKCRYCSKELPSVSEMKYYVPSKLIDMNQVDTNNDNQRLNKRIKKNAHCNQIRRNIQYVLNTSTAVPFKYRGKFSCFYCTQRFPNFDELISHTRAEHPVCELNSKAMQRCKGEKARIKLDINGLACKLCHQSMPDLKSFVDHAIAQHDAEYDKSVPLKDCFDSFHLTQGGTIPCPECQEPFAYFATLLKHLGVEHNHHKAVCAYCGRGFRSTNSLAMHISYSHTGTCECSVCNANCKNSAALARHMARFHDAKNFKCPQCPELFETIYKKQNHLIKAHNVGHKCTYCEKMYTRNSFMMNHVRRTHLKERTVPCSVCGDKFFSPYDLKLHMVKHNGDKKIVCNVCGKKFSKKSNLNTHTVLHTREKNFFCPVCDRAFAHQTTLKAHVKNRHQPYETEYNILDDMANNDMGEGVTKRQIQNRAIDRLTTVRRNISTVLRLSNAVPFNWNTKGFRCFYCAKSTQDCYLLKEHTLKHNAIDLDDFITKHIITKDVPIKIDITDLVCKVCQNPSANLDDFFAHIVDKHDEEYDASVGVCFFPFVLNKEVMQCLLCESNYDNFASMVGHMYKQHITHSYICQICGLSFKDQIRLKRHITNSHVGYRCTICKKTFSALHKLTKHKQRFHGQVKLHECSLCSEKFLNSYQVKVHMGKVHNVEKYMIKCQHCPKVCTTKGAMLLHVQGLHSEIRYQCDLCDYTAGIKWLIKLHKRKHFGLKDYSCSICERQFGRSSNLRTHMKVHTGKVGRVCRVCRKGFTDLQSYERHELEIHYYDHF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-