Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.0032 0.29 12.6 1.5 1 23 105 128 105 128 0.93

2 7 0.13 11 7.6 0.1 2 23 155 177 154 177 0.94

3 7 3 2.7e+02 3.3 0.9 3 23 201 221 199 221 0.90

4 7 0.00023 0.021 16.2 0.4 1 23 225 247 225 247 0.96

5 7 0.00031 0.028 15.8 0.8 1 23 252 275 252 275 0.98

6 7 0.032 2.9 9.5 0.6 2 22 283 303 283 305 0.88

7 7 0.00054 0.048 15.1 2.6 1 21 311 331 311 332 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.0032	0.29	12.6	1.5	1	23	105	128	105	128	0.93
2	7	0.13	11	7.6	0.1	2	23	155	177	154	177	0.94
3	7	3	2.7e+02	3.3	0.9	3	23	201	221	199	221	0.90
4	7	0.00023	0.021	16.2	0.4	1	23	225	247	225	247	0.96
5	7	0.00031	0.028	15.8	0.8	1	23	252	275	252	275	0.98
6	7	0.032	2.9	9.5	0.6	2	22	283	303	283	305	0.88
7	7	0.00054	0.048	15.1	2.6	1	21	311	331	311	332	0.95

Coding Sequence: ATGGCTTATAATCCAAATTACTTTAACAATAGATGTAGACAATGTTCTGAGGATATCATGGTGAACACTCTCcaaaaagagaaaataatacGGCAGTCCATAGCTGACATAGAAACCTATGCTGTGACCTGTCCCGATCCAGAATCCATACTGATCGAGATCGAGGTTGACACGGCTTCATTTTTCGTAACTTCCGAAGACGAAGAAGCTGAAGTCTCCACTCTCAACGAAGTTGATAAACACAGAGAAAATATCCGAACAATCCTTCTTGCATCAAATGCCACGCCGATTGGGAGATACGGGAGCCTCGGATACAACTGCTGCTATTGTACCGAAGTCTACTCAGCCCCCAGAGACTTAAAGAAGCACACAATCGAACAACATGACGAAGAAAACATCTCCTGTTATATGAACAATTACACAATGCTCAATTACATCGTCAAATTAGACATTACCGGTCTCCGCTGCGAAATGTGCATGAAACCGTTTAACGAACTACAAAAGTTGATAGACCATCTTACAATAGATCATCAGAAATTCTTCCACACGGACATAGGAAGTCACATCGTTCCATTCCGTTTCGATTCGGATGTGCTGCACTGCGTTGAATGCGCTTTCGAATACAATAACTTCAAAATCTTATTGGAACACATGAATACTCACTACGGTAACCATATTTGTGAGGTCTGTGAAGCTGGGTTTGTGAACAGGAGGATGTTGCAAGCCCACATGTATAGGCACAAAACTGGAACCTTCCAATGTGGGTTTTGCTCAAAAGTTTTTGATACTCGAATCAAAATGAAAGTTCATGAAAGAATGGTACACTTGTACGTGAAGAAAAGACCAAAGTGTACGATTTGTGAGAGGAAGTTTAATGACTTCCAGAAGATGATACAGCATGAGGCTGAAGACCACGGTCTTGAAAGAGAGTTCAAGTGTGAGCTCTGTAGCAGAATGTTTACGACTAAAAGATCTTTTACAATtcataaaaagttttattgtgtTCCTAATGATTAG
Protein Sequence: MAYNPNYFNNRCRQCSEDIMVNTLQKEKIIRQSIADIETYAVTCPDPESILIEIEVDTASFFVTSEDEEAEVSTLNEVDKHRENIRTILLASNATPIGRYGSLGYNCCYCTEVYSAPRDLKKHTIEQHDEENISCYMNNYTMLNYIVKLDITGLRCEMCMKPFNELQKLIDHLTIDHQKFFHTDIGSHIVPFRFDSDVLHCVECAFEYNNFKILLEHMNTHYGNHICEVCEAGFVNRRMLQAHMYRHKTGTFQCGFCSKVFDTRIKMKVHERMVHLYVKKRPKCTICERKFNDFQKMIQHEAEDHGLEREFKCELCSRMFTTKRSFTIHKKFYCVPND

Sequence clustering based on sequence similarity using MMseqs2