Basic Information

Gene Symbol
-
Assembly
GCA_954870645.1
Location
OX940946.1:5734739-5744254[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.01 1.3 11.1 2.3 1 23 332 353 332 353 0.91
2 13 6.4 7.9e+02 2.3 0.1 2 23 379 401 378 401 0.91
3 13 0.079 9.8 8.3 0.1 2 23 424 445 423 445 0.96
4 13 0.14 18 7.5 0.6 1 23 593 616 593 616 0.90
5 13 0.079 9.8 8.3 0.4 2 23 642 664 641 664 0.96
6 13 0.031 3.8 9.6 0.5 2 23 687 708 686 708 0.95
7 13 0.006 0.75 11.8 1.7 1 23 712 734 712 734 0.96
8 13 0.0027 0.33 12.9 1.9 1 23 739 762 739 762 0.94
9 13 0.042 5.2 9.1 0.6 2 23 770 792 770 792 0.91
10 13 7.9e-05 0.0097 17.7 3.9 1 23 799 822 799 822 0.97
11 13 0.00035 0.043 15.7 2.4 1 23 828 850 828 850 0.97
12 13 0.0023 0.28 13.1 6.0 1 23 856 878 856 878 0.98
13 13 1.6e-05 0.0019 19.9 2.4 1 23 884 907 884 907 0.98

Sequence Information

Coding Sequence
ATGTCTGCGGAAAAAAATGAGATACAGACGTTTTTCGGGAAATGTAGGTGTTGTCTTTCCTATGGCTACTTAAAAAACATGTGGACGGAACATCAATTCGAAGGACAAGCCGAAGTCTACGGCGAAATGCTTGTGCAATGTTTTGCTATGGCCtgggaagtCACAGACGATTCAATAGAACAGGATCAGATTTGCGAGCAGTGCATTAGTCGGTTACGGGATGCCCATGACTTTAAGAAGGTCATCCTGGAATCACAAGAGCAGCTGGTTCAACAAATTGATGATGACAACAAACAGATCATCAAAGAAGAAATACTAGAAGAAGACTTAGAAGAACATAGTGATATAGGTGATGATACTGCGGACACCATGCACGATGACATAGAATACACCATGGACACTGCTGACACTCCGAGTGTCAAAGATGAGACGGAGTATGAAGAGATTGAGTTTTTAGAGGATGAAGATAATGCGGGAGTGAATGAGACAGTTGATACTGACTCCTCACATGCAACAAATCCTTGGAAACAAGCCAGAAGGAAGAAACAGCCCCGAGAACCGCTCCCAGAAGGTGACGGTGACACACCGAAGCGCAAATGGCCGAAGAAGCTACCCAAATCGGAACGCCTCAAGACGTACAAACAATATTCTGAAATTGATCTGAGGAAATGTGTGGaagatatcaaaaataatttgattacTGTTTCTGAAGCGTCTTTGAAATATGACATACCGAAGAAGACTATTGATGCCAAAATCAGAAGGGAAGGACAAAATGTCGGGATTGACATCCAAAAAGATACATGCGAAACTGTGACAACAAGCCAAAAGGAAATACCAACACCATCACACGAAGAGGAAAAAAAGTCGGATTCTGAGACAGAAAACCAGAACACCTCAAATAAATTCATAATGCGAAAACATAAGCACAATCTCAAAATGATACTGAAATACTCAAACGCTACGctgattaaaaataatacagcTGCCGGTTACTCCTGCTGGTTTTGCAATAAACAGTTTAATCCAGAAAATCTGAAAAAACACAACTTTGAGCATGAAGATATATACGATGATGCTATTAAGGTACAATACGTCTCTGATCTAATAATGAAACTCGATATAACTGGACTTCAATGCAAGCTTTGTGAAGAAATAATCGACAGTATCGAAAAATTTATGAGTCATCTCCAAGAAGAACATAACAAAACTATATACACGGACATAGACAATCATTTTATACCTTTTAAATTTGATACGGAGGAGTTGCAATGTGCTATATGTGCCGCGGATTTCAAGTACTTCAAATTACTTACGGAGCATATGTCGGAACATTACGATGTCCTGATTGACAATACAACGAAATACAAATTGGAACAATCTAAAAAGAAACTGAGGAAAAAACCCACCATCTTTAAAGCCCAAGCATCATTTCTGGACGGAAATACAAAAAGACTTATAGAGCTGAATAAATTAAAAGCAAAAAGATTAAAAAATGAGATTATTGTAGCTATAaaagatgatgaaataaataaacaagcaAACGTGATCCCTATAGAGTATGATATTGAGCCTAAAATAGAAGAGATGGAGGTACCTGTGAACGCAGACCAAGTCAGGACCCGAAACaaggcaatagtcaatgacaaaTTCAAGAAAGGAAACCGAGAACCTGAAGAACTTGAAATTAACGAAATGAACaaacataaacataatataAGCATTATATTACAAAATTCTAACGCAACTGTCATCAAAGGATTTTGGGGAACTGGTTATTCTTGTAACTTTTGCGATCAACAGAGAGAATTACCATCAGAATTAAAACGACATAACTTGGAAACTCACAATAATATAACAGACGAAGTCGTCAAAGTAAAATACGTATCAGATTTAGTTATAAGACTAGACATTACCGATCTCAAATGCAAACTATGCAACGCAAATATAAACTCTTTGGAAGAATTTACGGAACATCTTAGAAAAATACATTCCAAAATCATACACACGGATATTAAAAACCATATAATTCCTTTCAAATTCAACACGGATAACTTACAATGCGTCATGTGTGCGAAAgagtttaaatatttcaagCTCCTTTCGGAACACATGAGCGACCATTACCGGAACTACGAATGCTCGTTTTGCGAGCGTGCCTTTATAAATAAGCAATCAATGCAAACACATAGTTATAGACATAACAAGGGAATTTTCAAATGCTCACATTGCCCTAAAGTTTTTGATTCGAGACCAAAGAAAAACCAGCATGAGAGAGCAGTGCATGCTCTTTCTAATAAAACACGAAAATGCTCGTTTTGTAGCGAAAGATTCGCTTCTAAAGACTTAGTGCAAAACCATGAGGTAAAAGTCCATGGTGTAAAACCTCCTGTGTTCTCTTGCCAATCTTGTAATAAATCTTATAATAGCCAAAGTTCGCTCACAAATCATAGAAAGCGCTATCATTTAATGTTAAGACCCCACAAATGCTCTTACTGCGACATGGCATTTTTCTCCAAAGTTGAATTGCGATCCCATACTGTGACTCATACGAAATCGAGGGATTTCAAGTGTGATATGTGCACGAAATCTTTTGGGACGCGATGTTGTTTAAATCAGCATGTTAGGGGACATTTAGATGATAGGCGATTCAAATGTGATGATTGTGAACGGACATTTGTCCATAGGACTGCTTGGAAAGTTCATATGAGGAGTAAGCATAGTCGGATAGTTTAA
Protein Sequence
MSAEKNEIQTFFGKCRCCLSYGYLKNMWTEHQFEGQAEVYGEMLVQCFAMAWEVTDDSIEQDQICEQCISRLRDAHDFKKVILESQEQLVQQIDDDNKQIIKEEILEEDLEEHSDIGDDTADTMHDDIEYTMDTADTPSVKDETEYEEIEFLEDEDNAGVNETVDTDSSHATNPWKQARRKKQPREPLPEGDGDTPKRKWPKKLPKSERLKTYKQYSEIDLRKCVEDIKNNLITVSEASLKYDIPKKTIDAKIRREGQNVGIDIQKDTCETVTTSQKEIPTPSHEEEKKSDSETENQNTSNKFIMRKHKHNLKMILKYSNATLIKNNTAAGYSCWFCNKQFNPENLKKHNFEHEDIYDDAIKVQYVSDLIMKLDITGLQCKLCEEIIDSIEKFMSHLQEEHNKTIYTDIDNHFIPFKFDTEELQCAICAADFKYFKLLTEHMSEHYDVLIDNTTKYKLEQSKKKLRKKPTIFKAQASFLDGNTKRLIELNKLKAKRLKNEIIVAIKDDEINKQANVIPIEYDIEPKIEEMEVPVNADQVRTRNKAIVNDKFKKGNREPEELEINEMNKHKHNISIILQNSNATVIKGFWGTGYSCNFCDQQRELPSELKRHNLETHNNITDEVVKVKYVSDLVIRLDITDLKCKLCNANINSLEEFTEHLRKIHSKIIHTDIKNHIIPFKFNTDNLQCVMCAKEFKYFKLLSEHMSDHYRNYECSFCERAFINKQSMQTHSYRHNKGIFKCSHCPKVFDSRPKKNQHERAVHALSNKTRKCSFCSERFASKDLVQNHEVKVHGVKPPVFSCQSCNKSYNSQSSLTNHRKRYHLMLRPHKCSYCDMAFFSKVELRSHTVTHTKSRDFKCDMCTKSFGTRCCLNQHVRGHLDDRRFKCDDCERTFVHRTAWKVHMRSKHSRIV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-