Basic Information

Gene Symbol
-
Assembly
GCA_954870645.1
Location
OX940946.1:6882940-6889075[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 28 0.36 45 6.2 0.4 1 22 65 86 65 88 0.87
2 28 0.035 4.4 9.4 0.1 3 23 117 138 115 138 0.92
3 28 0.2 25 7.0 0.2 1 23 208 230 208 230 0.94
4 28 8.4 1e+03 1.9 0.0 2 23 258 280 257 280 0.87
5 28 0.0011 0.13 14.2 0.2 2 23 301 323 300 323 0.96
6 28 0.0068 0.84 11.6 3.8 1 23 328 351 328 351 0.96
7 28 0.00017 0.021 16.7 0.4 1 23 355 378 355 378 0.95
8 28 0.33 41 6.3 0.2 2 23 381 403 380 403 0.95
9 28 0.006 0.74 11.8 0.2 2 19 409 426 408 428 0.96
10 28 0.0011 0.14 14.1 0.0 1 23 573 596 573 596 0.92
11 28 4.2e-05 0.0052 18.6 0.9 1 23 601 624 601 624 0.95
12 28 0.00019 0.024 16.5 0.1 2 22 631 651 630 653 0.90
13 28 0.00018 0.023 16.6 1.4 2 23 659 681 658 681 0.97
14 28 0.00051 0.063 15.2 3.0 1 23 718 740 718 740 0.98
15 28 0.057 7 8.7 0.0 3 23 769 790 767 790 0.94
16 28 0.084 10 8.2 3.3 1 23 810 833 810 833 0.95
17 28 6.4e-05 0.0079 18.0 0.6 1 23 838 861 838 861 0.96
18 28 0.0019 0.24 13.4 1.2 1 23 866 889 866 889 0.96
19 28 0.00088 0.11 14.4 1.4 3 23 893 914 890 914 0.90
20 28 0.015 1.8 10.6 1.3 2 21 922 941 921 942 0.94
21 28 0.016 1.9 10.5 2.6 1 22 996 1017 996 1019 0.90
22 28 2.4 3e+02 3.6 0.0 2 23 1092 1115 1091 1115 0.92
23 28 2.3e-05 0.0029 19.4 0.1 3 23 1122 1143 1121 1143 0.94
24 28 0.0024 0.29 13.1 2.0 2 23 1148 1170 1147 1170 0.94
25 28 0.0055 0.68 11.9 3.1 1 23 1175 1198 1175 1198 0.96
26 28 2.8e-05 0.0035 19.1 5.0 1 23 1202 1225 1202 1225 0.97
27 28 0.00033 0.041 15.8 0.3 2 23 1232 1253 1231 1253 0.96
28 28 1.2e-05 0.0015 20.3 0.6 1 23 1259 1281 1259 1281 0.98

Sequence Information

Coding Sequence
ATGCATGTGAGGAAATGCAAAGGCGAAGAGATTTTCGGAATTGCGATCAAAGAAGAAAACTCAGTGATGGATTTGGACGACCAGAATTATGAAGAACCGGTTAAAAAACCGTGCGTTAAACAACTCCGGGAAAATATTGTCATAATCATTAACATGTCTACTGCAATaccctttaatttttataagaaTAAGTTCAACTGCTTTTACTGTTCTAAAGATTTTGGCGATTCGGACGTCATGAGAGAACACACGGTCTTAGAACACCCAGTTTGCGATGTTAACGAAAAATGCATCAGAAAGTGTAGGGAATCGATATCCTGCGTCAAAATTGATATTTCTTCACTCGCTTGTAAGGTCTGCTTCGAATCATTGACTGATTTGGACAATCTAATAGATCATTTAATAGAAAAACATGACGCGAAATATGACAAATCGATTACAACGTGTCTACAACCTTATAGATTGATAAAAGACAATATGGTATGCCCACATTGCCCAAATGAAGTTTTCAACTTCTTCGATTTGGAAACAAAGGTGCACAGTGCTAGTTATCTAAGGAGGCGAAATCTGCAAATATTACTCAACCACACAACGTTGGTACCGTTTAAATGGCGTGGCAAATACCTCTGCTTTTATTGCGGTGACGATACGGAGACGCCCGAAAGTCTCCGGAATCATACGAAAGCTCACGGACCTTGCAGTGATAAAGACAGAGCAATACAACAAATAAAATCAGCTGATGTTGAAATCAAAATTGATGTTTCCGATGTTACCTGCGAGATTTGTTCAGAATCTTTACCATTTTTAGAcgaaattattgatcatttgaTATTTAAACACAATTTGCCATACGATAAAGACGTCGAGATGTCTCTATCAGCTTACAGACTCTCAGATCTCCAATGCCTTCTTTGCGACAAAAGTTACGACTACCTTCGTAAACTGATCACTCATATGAATGTTGCTCATCCGAATAACAGTTACGAATGCACTAAGTGTTCAATGAAATTCAATAAAAGAAGGGATTTAGAGTCACATAAGAGATTCCGTCATAAGAAATGCTATCCTTGCACGAAATGTGATCAAAAATTTCCTACTAACAACGCGCTACAAGTTCATAGATCTAACGATCATTCTTCAACCTGCAATATCTGTTTTCAAGTATTTCCATCAGATGCGAAAAGGTTAGCCCATCTCAAATCCGAACATGAATCTGAACAAAGCCAATGCGGATTCTGTAATAAAGTCTTCCCAACTAAACAAGCTTTTATAAGACACTCCGGTAAATGCGAGAAAACACCAGCCGAACAGCCTATCTTACACgacgaagaagaaaaaaagattTCTGttaaagaaataagaaaaagcTTAGCAGCCATCTTCAATATGACCACCGCATTACCTTTCAAATTCTTCATGAATAGGCTACGCTGTTTTTATTGCACGAAAGATTTTATCTGTTGTGAGGGTTTAAAGGAACATACGTTGAGCGACCACCCTCATTGCGATATAAACTTTAAGTCAATGAAGCTAAAGAACAGATATGACGGTGTTCAAATCAAAGTTGATACTTCTGATTTGTCGTGTAGACTTTGTCATATCAACTTGCAGGATTTGAACGATGTGGTCGATCATTTGACCAAAGAGCATAAGGTCAAATTCAACTTTACTGTTGAGGGTTACTTACTGCAGGCTTACAAACTGTTCAAAGACAACTATCCTTGTCCTATTTGCGGTGAAGTTTTCAGATACTTTGGGGTCTTGCTAAAGCATGTTAGTGCGTCACACACTGGAAACAATCACATATGCATGTACTGCGGAAAAGCTTTCAGAACAGACCCGAATTTAAGAGCTCATATTTCAAGAAGACATAAAATACCTGACAGTAACAAGTGCAGTACTTGCGGTCTTGTGTTTCCGACAAATTCTGCGTTAAAGAGCCATCAGGGAGCCGTTCATGGTAAAAAGTTAGTCAAATGCTTCAAGTGTAATGAGAAATTCACTTCGCAGTATGCCATGCAGAGACATTTGATCACCTCTCATGATGGTCTACCAGGGCCGTATGAAGGATGTACCTCTGAGAGACGGCGGAAAAACTTGGAAATACTGTTCAACCACACCACGATCATGCCTTTTAAATGGCGAGGCAAATATGTTTGCTTCTACTGCGGACAAAACTATACAGACTACACAGAATTTAGAAAGCATACTAAATCCCACGGACTATGCACTACTAAAGATTACTCCCTTAAACTGATCAAAGGGAACAACGTCGAGATAAAAATCGATGTATCTGAGATCGCTTGTGACATCTGCAATGAACCTTTCAACAGATTTGAAGAAATAATCGATCATTTGATCTCGAAACATAACTTGGAGTATAACAAAAACATCGAAGTACCTTTCCAGCAATATCGTTTAGTTGATTTTCATTGTTTGCATTGTGAAGAACAATTTTCTTACTTCGGTTATTTGGTTAAGCATGTGAATAATGTGCATCCGCAGAATTGTTTTATCTGCGACGATTGTGGAGCAACTTTTAACAAGAAGAGAGATTTGTATGTACATTTGAGGAATTACCATAAGCAAGGAGGATATCCTTGCGATTTATGCCTAAAGAACTTTGAAACTCGATTTATGTTGAGGACACATCAGAACAACATGCATTACAGATGCTGCAAGAGCTGTGGTTTGCGTTTCGCCTCCCTTTCTCTCTTACAAAAGCACGTACAAGTTGAACATCTACAAAATGAAAGCAATATGAAGTGTAGTTACTGCTCTAAGGAGTTCCACACGTCTTTAGGCTTACGACAGCATATCAGCAAATGTAAAGTGAAAATAATTTCGCAGGTCGAACCACAAACATCGTTCCTTGACGACAGTAACATAGAGCCTAAGAAAAAACAGAATATCTTACAAATAAGACAGAACATACAATGTGTATTAAACATGTCGACAGCAGTGCCTTTCAAATTCTTCTCCAAATACTCTTGCTTTTATTGCTCAAAGAAATTTGTAGAATTTGATGAGTTACGCCACCATACGGGTCTTGAACACCCCGTGTGCGATTTGAAGTCCAAAAGCATGAAGAAATGTAAAGGAGAAAGGATAACCGTTAAAATCGACATTTCTGCTTTAGCTTGTAAATTATGTTGTCTTCCTATGCCTAACTTAGATGATTTGATCAACCATCTGATAGCAGAACATAAAGCAAATTACGATACGTCAATTTCTGGATGTTTAGAACCATTCCGGGTTATAAAAGACAACATGCCTTGTCCCATATGCCCTGATACAGTCTTCAGATACTTCGGAATTCTGCTTCGTCATATGAGCTCGGAACATAGCAACAACAATCGAATTTGCGACTTTTGTGGTCGAAGCTTCCGTAACGCGGCAAATCTGAACGTGCATATAACTTACGCACATACAGGTTCATGCGAATGTGAAATCTGTGGAGTTAAATATAAGAACCAATGGTGTTTGGCACGGCATAGGGCGAGGATCCACGATGCTAAGGACCATAAATGTCCGAAATGCCCCGAGCAGTTCCAGTCTCAGtaccaaaaacaaaaacatttgataaaaatgcataatgTAGGTCATAAGTGTAGTTACTGCGGTAAAATGTTCACGAGAAACTCTTTTATGAAAGACCATGTTAGAAGAACGCATTTGAAAGAGAAGAACATACCTTGCTCTATTTGTAATGaaaagttttttgataattatcTTTTAAGGATGCATATGGTAAAACATGAGGGGGATAGAAAATTCAGTTGTACAGTTTGCGGAAAAGCTTTTTTGAGGCGGAGTAACTTGAGCTCGCATATGGAGATGCATAAGAAATATGGCCATGTGCAGTTATAG
Protein Sequence
MHVRKCKGEEIFGIAIKEENSVMDLDDQNYEEPVKKPCVKQLRENIVIIINMSTAIPFNFYKNKFNCFYCSKDFGDSDVMREHTVLEHPVCDVNEKCIRKCRESISCVKIDISSLACKVCFESLTDLDNLIDHLIEKHDAKYDKSITTCLQPYRLIKDNMVCPHCPNEVFNFFDLETKVHSASYLRRRNLQILLNHTTLVPFKWRGKYLCFYCGDDTETPESLRNHTKAHGPCSDKDRAIQQIKSADVEIKIDVSDVTCEICSESLPFLDEIIDHLIFKHNLPYDKDVEMSLSAYRLSDLQCLLCDKSYDYLRKLITHMNVAHPNNSYECTKCSMKFNKRRDLESHKRFRHKKCYPCTKCDQKFPTNNALQVHRSNDHSSTCNICFQVFPSDAKRLAHLKSEHESEQSQCGFCNKVFPTKQAFIRHSGKCEKTPAEQPILHDEEEKKISVKEIRKSLAAIFNMTTALPFKFFMNRLRCFYCTKDFICCEGLKEHTLSDHPHCDINFKSMKLKNRYDGVQIKVDTSDLSCRLCHINLQDLNDVVDHLTKEHKVKFNFTVEGYLLQAYKLFKDNYPCPICGEVFRYFGVLLKHVSASHTGNNHICMYCGKAFRTDPNLRAHISRRHKIPDSNKCSTCGLVFPTNSALKSHQGAVHGKKLVKCFKCNEKFTSQYAMQRHLITSHDGLPGPYEGCTSERRRKNLEILFNHTTIMPFKWRGKYVCFYCGQNYTDYTEFRKHTKSHGLCTTKDYSLKLIKGNNVEIKIDVSEIACDICNEPFNRFEEIIDHLISKHNLEYNKNIEVPFQQYRLVDFHCLHCEEQFSYFGYLVKHVNNVHPQNCFICDDCGATFNKKRDLYVHLRNYHKQGGYPCDLCLKNFETRFMLRTHQNNMHYRCCKSCGLRFASLSLLQKHVQVEHLQNESNMKCSYCSKEFHTSLGLRQHISKCKVKIISQVEPQTSFLDDSNIEPKKKQNILQIRQNIQCVLNMSTAVPFKFFSKYSCFYCSKKFVEFDELRHHTGLEHPVCDLKSKSMKKCKGERITVKIDISALACKLCCLPMPNLDDLINHLIAEHKANYDTSISGCLEPFRVIKDNMPCPICPDTVFRYFGILLRHMSSEHSNNNRICDFCGRSFRNAANLNVHITYAHTGSCECEICGVKYKNQWCLARHRARIHDAKDHKCPKCPEQFQSQYQKQKHLIKMHNVGHKCSYCGKMFTRNSFMKDHVRRTHLKEKNIPCSICNEKFFDNYLLRMHMVKHEGDRKFSCTVCGKAFLRRSNLSSHMEMHKKYGHVQL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01527571;
90% Identity
-
80% Identity
-