Basic Information

Gene Symbol
Hr78
Assembly
GCA_954870645.1
Location
OX940943.1:14426505-14438911[+]

Transcription Factor Domain

TF Family
RXR-like
Domain
zf-C4|RXR-like
PFAM
AnimalTFDB
TF Group
Zinc-Coordinating Group
Description
DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinates a single zinc atom. RXR functions as a DNA binding partner by forming heterodimers with other nuclear receptors including CAR, FXR, LXR, PPAR, PXR, RAR, TR, and VDR. All RXR heterodimers preferentially bind response elements composed of direct repeats of two AGGTCA sites with a 1-5 bp spacer. RXRs can play different roles in these heterodimers. RXR acts either as a structural component of the heterodimer complex, required for DNA binding but not acting as a receptor, or as both a structural and a functional component of the heterodimer, allowing 9-cis RA to signal through the corresponding heterodimer. In addition, RXR can also form homodimers, functioning as a receptor for 9-cis RA, independently of other nuclear receptors. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, RXR has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [cite:PUB00121610], [cite:PUB00121611], [cite:PUB00121612], [cite:PUB00025660], [cite:PUB00121613], [cite:PUB00092048], [cite:PUB00092725], [cite:PUB00092726], [cite:PUB00016724], [cite:PUB00059514PMID:18971932
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 0.014 1e+02 4.1 0.0 1 26 270 295 270 298 0.94
2 4 0.014 1e+02 4.1 0.0 1 26 386 411 386 414 0.94
3 4 0.014 1e+02 4.1 0.0 1 26 502 527 502 530 0.94
4 4 1.3e-32 9.7e-29 102.1 0.6 1 196 618 830 618 832 0.82

Sequence Information

Coding Sequence
ATGGAAGGTCAGGACCAGATGGATGTGAAGTTTGGCGGTGAGGTGGGGGGGTTGGAGCTCTGCATTGTGTGCGGAGACAGGGCTTCCGGCAGACATTATGGAGCCATCAGCTGTGAAGGCTGCAAAGGCTTCTTTAAGCGCTCAATCCGCAAGAAGCTGGGCTACCAATGCCGTGGTAGCATGAACTGCGAGGTTACCAAGCACCATCGGAACCGTTGCCAGTACTGCAGGCTTCAGAAGTGTCTCGCGTGCGGCATGAGAAGCGACTCGGTCCAGCATGAACGGAAGCCGATCGTGGACAAGTCCAAGGCTGAGCAGCGCGAGGGCTTGCACGACAGGCAGGCCGTGTACTCCAAGTTCTTGGGGCTGGCGGGACAGGCTCAAGGTGGACAGATCAATCCCAAAGAAGAGCCGAGTGACTCTGCGTTCGGCGCGGTGTCTCCTGCGCCGGCGATCAACTTCGCGCTCGCTGCAGCGGTCGCGTTCAACAAGGGTAATCCAGTGTCGCCATACCTAACGCCGGGCAACGCGGGTGATATCGAAGGCGCTCGCAGACAGCAACAGTTGATGTTACAACAGCAACTTGCTAAGAATCTCTTCAAAATGGGGCAGTTTGgtgCAATCAATGAGTATCTTCAAGCTTACGGCGCGACCCCGCCAGAGGTGCCACTCGCTGCTCTACACGCCGCCGCCGAGACACAACAGACTGAAGACGCTCCAGGCGGAGGTATCCTGAGCACTCCAGAGTCAGTCCAGCTCCTGGTGTCCCTCCCGGGCGCGGCCCCCGCACACCTGCGCCTGCACGCCGTGTGCGAGGCAGGAGCCAGGCTGCTGGCAGCGGCAGCGAGGTGGCTCCGAGCAGTGCCTGCTGCACACGCGCTACCGTATGTATCACTCAGTACAGCTGCTGGTGTCACACCTGCGTGTGCGAGGCAGGAGCCAGGCTGCTGGCAGCGGCAGCGAGGTGGCTCCGAGCAGTGCCTGCTGCACACGCGCTACCGTATGTATCACTCAGTACAGCTGCTGGTGTCACACCTGCGTGTGCGAGGCAGGAGCCAGGCTGCTGGCAGCGGCAGCGAGGTGGCTCCGAGCAGTGCCTGCTGCACACGCGCTACCGTATGTATCACTCAGTACAGCTGCTGGTGTCACACCTGCGTGTGCGAGGCAGGAGCCAGGCTGCTGGCAGCGGCAGCGAGGTGGCTCCGAGCAGTGCCTGCTGCACACGCGCTACCGTATGTATCACTCAGTACAGCTGCTGGTGTCACACCTGCGTGTGCGAGGCAGGAGCCAGGCTGCTGGCAGCGGCAGCGAGGTGGCTCCGAGCAGTGCCTGCTGCACACGCGCTACCGTATGTATCACTCAGTACAGCTGCTGGTGTCACACCTGCGTGTGCGAGGCAGGAGCCAGGCTGCTGGCAGCGGCAGCGAGGTGGCTCCGAGCAGTGCCTGCTGCACACGCGCTACCGTATGTATCACTCAGTACAGCTGCTGGTGTCACACCTGCGTGTGCGAGGCAGGAGCCAGGCTGCTGGCAGCGGCAGCGAGGTGGCTCCGAGCAGTGCCTGCTGCACACGCGCTACCGTATGTATCACTCAGTACAGCTGCTGGTGTCACACCTGCGTGTGCGAGGCAGGAGCCAGGCTGCTGGCAGCGGCAGCGAGGTGGCTCCGAGCAGTGCCTGCTGCACACGCGCTACCGTATGTATCACTCAGTACAGCTGCTGGTGTCACACCTGCGTGTGCGAGGCAGGAGCCAGGCTGCTGGCAGCGGCAGCGAGGTGGCTCCGAGCAGTGCCTGCTGCACACGCGCTACCGTATGTATCACTCAGTACAGCTGCTGGTGTCACACCTGCGTGTGCGAGGCAGGAGCCAGGCTGCTGGCAGCGGCAGCGAGGTGGCTCCGAGCAGTGCCTGCTGCACACGCGCTACCATTCGAGATCCAAGTGACCCTCCTAAAGAAGTGCTGGCCGGAGCTGTTCGTGCTGTCGCTGTCGATGTTCTCCCAGCAGCTGTCGCTCAACAGTCTGCTGCCGCAGATGGTGAGCCACCTGCAGGCAGTACTGCGGGACAGGGCCAGCAACGACTGTGTGGACCGCTCACATGATATGACCATGCCGGAGATCACAGCGTCGGACTACTCGGACGAGCGTATAGCCGAAGTGAGCAGTAGTCTGTCGCGACTGCAGCAGTTCATCACCAACATGGAGCAGCTGCGAGTGCAGCAGAGGGAACACGCGCATCTCAGGGCGCTGTGCTTGTTCTCACCAGACGGCGTCCCAGATTTCTTGACGCGCAAACTCCAAGACTATCAGATCAAGGTCTTACGTTCATTAAGAGCATCATGCCAGCCGGATGAAGATCGTCTGGCTACCTTACTGCTGCAGCTACCAGTTTTAAGAACCTTCTCCGGACCCTTCCTTGAAGATGTCTTCTTCGTTGGCTTTGTAGGAGATGTCAGCATTGATGATGTTATTCCTTATTTGTTGAATGCTGAGCGCTAG
Protein Sequence
MEGQDQMDVKFGGEVGGLELCIVCGDRASGRHYGAISCEGCKGFFKRSIRKKLGYQCRGSMNCEVTKHHRNRCQYCRLQKCLACGMRSDSVQHERKPIVDKSKAEQREGLHDRQAVYSKFLGLAGQAQGGQINPKEEPSDSAFGAVSPAPAINFALAAAVAFNKGNPVSPYLTPGNAGDIEGARRQQQLMLQQQLAKNLFKMGQFGAINEYLQAYGATPPEVPLAALHAAAETQQTEDAPGGGILSTPESVQLLVSLPGAAPAHLRLHAVCEAGARLLAAAARWLRAVPAAHALPYVSLSTAAGVTPACARQEPGCWQRQRGGSEQCLLHTRYRMYHSVQLLVSHLRVRGRSQAAGSGSEVAPSSACCTRATVCITQYSCWCHTCVCEAGARLLAAAARWLRAVPAAHALPYVSLSTAAGVTPACARQEPGCWQRQRGGSEQCLLHTRYRMYHSVQLLVSHLRVRGRSQAAGSGSEVAPSSACCTRATVCITQYSCWCHTCVCEAGARLLAAAARWLRAVPAAHALPYVSLSTAAGVTPACARQEPGCWQRQRGGSEQCLLHTRYRMYHSVQLLVSHLRVRGRSQAAGSGSEVAPSSACCTRATVCITQYSCWCHTCVCEAGARLLAAAARWLRAVPAAHALPFEIQVTLLKKCWPELFVLSLSMFSQQLSLNSLLPQMVSHLQAVLRDRASNDCVDRSHDMTMPEITASDYSDERIAEVSSSLSRLQQFITNMEQLRVQQREHAHLRALCLFSPDGVPDFLTRKLQDYQIKVLRSLRASCQPDEDRLATLLLQLPVLRTFSGPFLEDVFFVGFVGDVSIDDVIPYLLNAER

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

90% Identity
iTF_00043563;
80% Identity
iTF_00040002;