Basic Information

Gene Symbol
-
Assembly
GCA_949152395.1
Location
OX424500.1:22108775-22130010[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.002 0.25 13.3 2.4 1 22 1537 1558 1537 1561 0.92
2 12 0.0025 0.31 13.0 3.5 2 23 1691 1713 1690 1713 0.94
3 12 0.0083 1 11.3 0.0 1 23 1719 1741 1719 1741 0.95
4 12 0.067 8.4 8.5 0.1 1 23 1751 1774 1751 1774 0.89
5 12 6.9e-07 8.6e-05 24.2 3.5 1 23 1779 1801 1779 1801 0.98
6 12 0.00098 0.12 14.3 0.9 1 23 1807 1829 1807 1829 0.95
7 12 0.00033 0.041 15.8 4.9 1 23 1835 1857 1835 1857 0.98
8 12 3.3e-07 4.1e-05 25.2 0.4 1 23 1863 1885 1863 1885 0.98
9 12 0.0092 1.2 11.2 4.1 1 23 1891 1913 1891 1913 0.98
10 12 0.00035 0.044 15.7 0.3 1 22 1919 1940 1919 1940 0.96
11 12 0.00019 0.024 16.5 0.8 1 23 1947 1969 1947 1969 0.98
12 12 1.7e-05 0.0022 19.8 3.6 1 23 1975 1998 1975 1998 0.96

Sequence Information

Coding Sequence
ATGGATTACaaatcattaattaaaaaacGTGGAACCTTTAAGGCAAAATTAACtcaatttaaatcatatttagaAATAGTAACAAGTTGTGATACTTTAAGTACCTTACAAATTAGTGAATTAAAAATAAGGTTAACAAAAATAGAGGAGTTATATCCTGAATATGATAGTATACAAAGTGACATAGAGAATGTATCTGATATTCCAGAGGACCAGTATAAAGAACGCGAAACCTACGAGATCCAGTACTATGCTGCGATTGCTGTAGCCCAGGAGCTGTTGAGTAAGCAGGAGACCTCTGCGGGCAATGGATCGGTTACAGGTGCTAGTACTGTTTCTGGAAATAAAGGTGGGATAAAACTTAAACTTCCTACAATACATTTACCTACCTTTTCGGGTCAATATCACAACTGGCTTGAGTTCCATGACACGTACGTCTCATTAATACATTTAAATGACACTATTCCGAGAATTAGTAAATTTCATTATTTGCGAGCTGCTTTAAAGGATAGTGCTGCTTTAATAATAAGTTCTCTTGACTTCTCCGATGAAAATTATGATGTTGCATGGCAGCTACTGTGTGACCGCTATAATAATAGACGGCTGCTAGTTTACAATCATGTTCAAGCTATCATTAATATTGAACATGGAACGCAAGAATCCTTTAAAGTTCTGCGCAACATCATTGATACAGTCAATCGTAACATAAGAGCTTTGAAAACACTTAAGTTGCCCACAGATGGTTGGGATGTGCTCATTATACACATAGTCTCAAGTAAATTGGATTCAGTGACAAGTAGGGAATGGGAAACTTACCGTAATGCATTAGATGACTTAGCCACACTTGCTGATTTTAACAAATTTCTTAAGAATAGAGCAGATTTATTAGAAACTATTGCGGAGGTTCACAACAATGGTTCGAAAGGAAGACATAGTGGCAGTACCAAACAAGGTGATAGTACAAATAAGCAAAAGACATTTACTGTCAACTCGGAGTCTTCAATCAATAACAGACCGTATAGTTGTCCATTATGTAAGGGTAACCATGCCATTTATAAATGCTCAAGTTTTAATTCGCTTTCTATTGAAGCTCGTATTCAGAAGGCAAGATCCCTTAACCTGTGCCTTAACTGCTTACGTAATGGTCATAAATCATTTAAGTGCAAGATGGGTGGCTGCAGCCACTGTCAGAAACGACACAACACCATGTTGCATTTGAATGGGCCATCCAGTACACAGGATACAAACAATGGTAGTACTGATTCTCCACATACTTCTACACAACCTACTCCGGACACTAGTAGTATAGTACTCTGCACAGCACAGTCAAACACACAGTTGTCAACAAACTCACAAAATAATGTGGTTCTGTCAGCCACTCATAATCCCCAATGTGTTATATTGCTGTCAACGGCTACCATTAATATTACTGATCACAGTGGTCAGAAACACAGAGTCCGTGCATTATTAGACAATGGCAGCACATCAAGCTTCATTACAAAAAGCCTATGTGACAAACTCAAATTACCAACTCGTTCAACCTCGACATTAGTTGAAGGGTTAAATCGTCAATCTAGTTGCATATCTAAAAGATGTGATGTCGTTATATCATCACTCATTAGTTCATATTCTGAGAGCATAAATTGTTTTGTGGTTCCACACATTACTCAAGCATTACCTTGCAAACAAGTCAACCATAAAGGGCTAGATATACCCCAAAATATTACATTAGCGGATCCTTTATTCCACACACCGTCACAAGTAGACATACTGCTTGGAGCGGACTTATTTTGGAGTGTattgctaaataataatatttcattagGTAAAAATAAGCCCACATTAAGTGAAACAAAGTTTGGATGGTTGATATCTGGACCCACACACTCATTACAACATAGCATTGATACAGTCCACTGCAATCATTCAAGTACACATTATGATGATCAACTTCAAGATCAATTAACCAAATTTTTTGAACTTGAAACGGTCACAGTGCACAAACCTGTATCCAAAGAGGAACAGGAATGTGAAGATAATTTTATACATACTACTACTCGTGGAAATGATGGTCGATTCATTGTAACAATTCCATTAAAAGAATCGCCTCAACAGCTGGGTAGTTCATATGAACAAGCCCTGTCTAGGTTCATCTCATTAGAACGTAGGTTTAAGCGTGACCCTTTATTCAAAAAGCAATATGCTGAATTCATTAAGGAATATATATCGTTAGGTCACATGACTGAAAATAAAACTCCAGATAAGGATGAATACACATATATTATGCCACATCATGGAGTGTTACGTGACACAAGTTTAACAACAAAATTAAGAGTTGTTTTTGATGCATCTGCAGCAACCTCATCAGGGTTATCGTTTAACAATATTCAAATGGTCGGCCCTACAGTACAAAGTGACCTCGTTAGTATATTAATTAGATTCCGACAGTTTAAACATGTTGTTACTGCGGATGTTGAAAAAATGTATAGAATGGTAAGGGTAATTGAAAGCCAACATATGTTACAACAGATACTATGGCGTTTTGAACCTGACGAACAGCTTAAACAGTACAAACTCAACACTGTAACTTATGGTACTGCATCTGCACCATATCTTGCAACCCGATGTCTAGTTCAACTGGGAAAAGAATGCTCTGATAAGTCCATTTCAGATGCTATCATTAAAGGATTTtatgttgatgattttatttatggAGACAATGATATGTCTAAGCTGATAGACATCTGCAGAGGCGTCATTAACCAACTAGAAAGCGGACAACTACATTTGAGAAAATGGAATTCAAATAATTCACACATTATACAACAACTCATAGGTGAAAATAGCAAAGATgaattacttaatttaagtaACCATGAGTTTTCAAAAACGTTAGGATTACTTTGGGGTTGTAAAGAAGATGTGTTGTTATTTTCAGCAGACATTAAGCAACATGAACACATCACAAAACGCACAATCTTGTCCACCATGGCTCAAATATTTGATCCACTTGGACTCATTAACCCTTGCATATTGCAAGCTAAAATCATTCTACAAAAATTATGGACATTAAAAATTACATGGGATGAAAATGTTTCAAGTGAGATTCAAGCAGCTTGGTGTAACTTTATCAAATCATTAGGTGACATTAGGAAAATAAGAATACCCAGACATGTCACCTGTGACTATCCTGTCATTTGTGAACTGCATGCCTTTAGCGACGCATCAACACAAGCTTACAGTACTTGTATTTATCTACGGTCTGTGTCCCAAAATAATGAAGTGACAGTGAAGTTGGTGACTGCAAAGAGCCGTGTAGCTCCACTGAAACCAATGACAGTACCACGGTTGGAATTGAGTGGAGCTCTATCAGCAGCTCGTTTAGCAGATAAAGTAAAATCTTCATTAATGGGACTTCACAGTTGCACTTACTGGTGTGACTCGACCATTGTATTAGCTTGGATTAATACTTCCAAGCCCAATCTATTAAAACCATTTGTTTATAACAGAATTCATGAACTGAAGTCTCTTACAGAACCAGGTACTTGGCgttatgtacctacaaaatTGAACCCTGCTGACATAGGGTCGCGCGGCGCAGATGCTTGCAACCTGGGATCCAATAGCTTGTGGTGGTCAGGACCTGCATTTCTAACAGAACCAGAGTCTAATTGGCCTGGCCCACCAACAACCATTAAGGAAGATGACTTGCCAGAATTCAAGGTTCAAAGTCATTTAAATGTCTCAGAGCAACAACCAGTTGAATTCGTGAGCCGATTTTCCGATTTTAGCAGAATCACACAACCAATAATGGGCAACCTTCCTGAGCAGCGACTACATGCTGATTACCCATTTATAAACACAGCAGTAGATTATGCAGGACCAGTGATGATTTTGAACCGAAAGGGTAGAGACCTAGTAGCCCTCACACCGTCACATTTCCTTCTTGGACGAACATTAACTGTTTTACCCTCTCCTCCAGCACAAGATACTACAAGGTTGAGCACTTTCTCACGATATATGAGAACTCAACAGTTGAAGACCCATTTCTGGGATAGATTTTACAAAGAGTACATTACAGAACTGCAAAAAAGACAGAAATGGTGCAAAGGAGGAAGAGACCTGCGACTTGGAGAGATGGTGCTGGTCAAGGATGATCGACTGCCACCAAACAGATGGCTGCTCGGGCGAATAACCAGCGTGTATCCGGGCTCCGACGGTGTGACCAGGGTAGCAGACGTGAAGACAACATCGGGCACTCTTCGGCGCGCCTTCAATCGACTGTGCCCGCTACCAGTTGAAGATCAGCCTGATGGTAAAGAGCTTGAGAGAATATTCAAAGAAGAAGGAGTTACTGACGGAGATGAGAGTGAGCCTGACTTGAAGATAGAACAGCACCTAGACTTGAAGCCACCTGTGCCTAAAGAACCGGAAGTTATCGGTCATCTAGAGGATTCTGGTGAACTTGTTGTCGTGGTCAAGGGCAAAGGCCGCGGGAGGCCTAAAGGTCCGATGACACCAAGCCGCAAAGAATGCGCGATTTGCGGCATGGAGTTTACCTGCACTGGCCGATACATGTCGCACGTGGCCCAACATGGCCCAGTGCTGTACCAGTGTGGGCAGTGCTCCGAGACCTTCACCACACGTTTGCACTTCAACAACCATCAGAAGGAATTGGGACATACTGGACAGAATATTATACCGTGCAAGAAGAATGTTGAGAGAATTAGGGCTAAGAAAAGTGACAGACCAAGAACTGAAACAATAGTAATACAAGATGACCCTCAACCGCTAACAACGAAGTCTGATACTGTACAAATATTAGAAAATGTGATATTACCTCGTACTATAGCAACCTCCTTGCCGGATTTAAATCCTCAGCCAATAGTTATTGACAATGTTGACAATGGGTCAGAGTTCCTGAAGGCTGGCCCTGCCATTGAGATTACCTCTAGTCCTAGTGTTGAAAGTGATGTTAAAATTGTTGatTCGACCACGGACGCCACTACGACAGAGAAGTCTGATGACGTAGAACTAGTAGAAACAACTCCGTCCGGTAAACCAAGACTGAAGTGTAATCACTGTGACAAGACTTTCAGTAGTAAACAGAGCAAATCTTTACATATCAAGGCGTCACATCAAGGTGAACGCCCATACGTATGCGGTGAATGCGGCGCGCGGTTCGCTTACCCGCGCTCACTCGCGTTACACGCTGTGTCACATCGACGACGCGCCGGCAATTCTAAGGGCTATGCGTGTGATCTGTGTGGGAAGGTCCTGAACCACCCGTCGTCGGTAGTATACCACAAAGAAGCAGAGCACGCGGGCCAGCGATACGTGTGCAACAAATGCGGCAAGTCGTTCAAACACAAACAGCTGCTTCAACGACACCAGCTCGTGCACTCACAGGACAGGCCCTATAATTGTAAGTTATGCAGCGCATCATTTAAGACGAAGGCGAACCTTCTGAACCACTCGCTGCTACACTCCGGCGTCAAGAAGTTCTCGTGTGAGATATGCAAGCACAAGTTCGCGCATAAGACTAGTCTCACGCTGCATATGAGGTGGCATACTGGTCAAAAGCCCTACTCCTGCAACGTTTGCGGCAAGAGCTTCAGTCAGAAAGGGAACCTGTCTGAACATGAGCGCATCCACACCGGAGAGAAGCCCTTCCAATGTTCTCTGTGTCCGCGCAAGTTTACCACCTCCAGCCAACATCGGTTGCATGCGAGGCGGCACAACTCTGATAGACCGTTCACTTGCGCGCATTGTGGGAAGAGgTTCGTGTCGCGCGGCTCGTGGGCGGCGCACACGCGGCGCGAGGGCGGCGGACGCACGCACCGCTGCGGCGAGTGCGGGCGCACGTTCGCGGAGCGCTGGCCGCTGCTGAAGCACCTGCGCAAGCACTCGGGCGAGCGGCCCTTCCGCTGCCCGCACTGTCCCCGGGCCTTCGCCGATTGCTCCAATCTTAATAAGCATAAGAAGCAAGTCCACAAACAGATCAGCTTACTGGCGACCGCGAACCAACCGCCGGTTCATCATTCACCCATTCCTCTGAAGATAGAGCAACCAGATTCCCCTCTCATACAGTTGGAGGAACAGATTGTTTCCCTCCCGGAGACATCTCCCGTCAAATTACTGGAGCAAGCGACGGAAGATGAGTTGGAAGAGAGAGTTATATACGTGACGTATGATGTGGATGATGCTGAATCGCCCGCCTTCCATATATTGGACCCTGAACAGGCAGCAACTTTAGAAGACGGTAAGGTGCTAACAACATGCGAGCTATACTCGGGCCCATCCCTTCTCGTCCCGCAGCCCGAATACGAGCAACTCGAGCTGGAACACGAGCAATTAGAGCTTGACCATGAGCAACTCGAGCAGGAAGAACTCGTGCAGTTACCTGAGGAGCTTGTGTTGGAAGGACATGATCAAAATATGCCTGTAACGGATGAGCAGGGTAATCCACTACACTTCACCATGCAGGATGGCACACGACTCGCCATCACTTCAGCCGATGGAAAGTCTTTACAAGTGATAACACACGATGGTCAAACCATACCTGTTGAGATTAACGGATACGCAGATGAGgaggaGGTTGACAATCCCGACACAATAGTTCACCAGCTGAACTTACAGAAGAGCATCGACTCCAACGTGTCGTCGCCTGTAACTCACTACTTCAcaattgtttaa
Protein Sequence
MDYKSLIKKRGTFKAKLTQFKSYLEIVTSCDTLSTLQISELKIRLTKIEELYPEYDSIQSDIENVSDIPEDQYKERETYEIQYYAAIAVAQELLSKQETSAGNGSVTGASTVSGNKGGIKLKLPTIHLPTFSGQYHNWLEFHDTYVSLIHLNDTIPRISKFHYLRAALKDSAALIISSLDFSDENYDVAWQLLCDRYNNRRLLVYNHVQAIINIEHGTQESFKVLRNIIDTVNRNIRALKTLKLPTDGWDVLIIHIVSSKLDSVTSREWETYRNALDDLATLADFNKFLKNRADLLETIAEVHNNGSKGRHSGSTKQGDSTNKQKTFTVNSESSINNRPYSCPLCKGNHAIYKCSSFNSLSIEARIQKARSLNLCLNCLRNGHKSFKCKMGGCSHCQKRHNTMLHLNGPSSTQDTNNGSTDSPHTSTQPTPDTSSIVLCTAQSNTQLSTNSQNNVVLSATHNPQCVILLSTATINITDHSGQKHRVRALLDNGSTSSFITKSLCDKLKLPTRSTSTLVEGLNRQSSCISKRCDVVISSLISSYSESINCFVVPHITQALPCKQVNHKGLDIPQNITLADPLFHTPSQVDILLGADLFWSVLLNNNISLGKNKPTLSETKFGWLISGPTHSLQHSIDTVHCNHSSTHYDDQLQDQLTKFFELETVTVHKPVSKEEQECEDNFIHTTTRGNDGRFIVTIPLKESPQQLGSSYEQALSRFISLERRFKRDPLFKKQYAEFIKEYISLGHMTENKTPDKDEYTYIMPHHGVLRDTSLTTKLRVVFDASAATSSGLSFNNIQMVGPTVQSDLVSILIRFRQFKHVVTADVEKMYRMVRVIESQHMLQQILWRFEPDEQLKQYKLNTVTYGTASAPYLATRCLVQLGKECSDKSISDAIIKGFYVDDFIYGDNDMSKLIDICRGVINQLESGQLHLRKWNSNNSHIIQQLIGENSKDELLNLSNHEFSKTLGLLWGCKEDVLLFSADIKQHEHITKRTILSTMAQIFDPLGLINPCILQAKIILQKLWTLKITWDENVSSEIQAAWCNFIKSLGDIRKIRIPRHVTCDYPVICELHAFSDASTQAYSTCIYLRSVSQNNEVTVKLVTAKSRVAPLKPMTVPRLELSGALSAARLADKVKSSLMGLHSCTYWCDSTIVLAWINTSKPNLLKPFVYNRIHELKSLTEPGTWRYVPTKLNPADIGSRGADACNLGSNSLWWSGPAFLTEPESNWPGPPTTIKEDDLPEFKVQSHLNVSEQQPVEFVSRFSDFSRITQPIMGNLPEQRLHADYPFINTAVDYAGPVMILNRKGRDLVALTPSHFLLGRTLTVLPSPPAQDTTRLSTFSRYMRTQQLKTHFWDRFYKEYITELQKRQKWCKGGRDLRLGEMVLVKDDRLPPNRWLLGRITSVYPGSDGVTRVADVKTTSGTLRRAFNRLCPLPVEDQPDGKELERIFKEEGVTDGDESEPDLKIEQHLDLKPPVPKEPEVIGHLEDSGELVVVVKGKGRGRPKGPMTPSRKECAICGMEFTCTGRYMSHVAQHGPVLYQCGQCSETFTTRLHFNNHQKELGHTGQNIIPCKKNVERIRAKKSDRPRTETIVIQDDPQPLTTKSDTVQILENVILPRTIATSLPDLNPQPIVIDNVDNGSEFLKAGPAIEITSSPSVESDVKIVDSTTDATTTEKSDDVELVETTPSGKPRLKCNHCDKTFSSKQSKSLHIKASHQGERPYVCGECGARFAYPRSLALHAVSHRRRAGNSKGYACDLCGKVLNHPSSVVYHKEAEHAGQRYVCNKCGKSFKHKQLLQRHQLVHSQDRPYNCKLCSASFKTKANLLNHSLLHSGVKKFSCEICKHKFAHKTSLTLHMRWHTGQKPYSCNVCGKSFSQKGNLSEHERIHTGEKPFQCSLCPRKFTTSSQHRLHARRHNSDRPFTCAHCGKRFVSRGSWAAHTRREGGGRTHRCGECGRTFAERWPLLKHLRKHSGERPFRCPHCPRAFADCSNLNKHKKQVHKQISLLATANQPPVHHSPIPLKIEQPDSPLIQLEEQIVSLPETSPVKLLEQATEDELEERVIYVTYDVDDAESPAFHILDPEQAATLEDGKVLTTCELYSGPSLLVPQPEYEQLELEHEQLELDHEQLEQEELVQLPEELVLEGHDQNMPVTDEQGNPLHFTMQDGTRLAITSADGKSLQVITHDGQTIPVEINGYADEEEVDNPDTIVHQLNLQKSIDSNVSSPVTHYFTIV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-