Basic Information

Gene Symbol
-
Assembly
GCA_949152395.1
Location
OX424510.1:13435489-13442136[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.00011 0.014 17.3 0.0 1 23 37 59 37 59 0.97
2 11 6.7e-06 0.00084 21.1 2.1 1 23 65 87 65 87 0.99
3 11 0.022 2.7 10.0 1.8 1 23 94 116 94 116 0.98
4 11 3.6e-07 4.5e-05 25.1 2.3 1 23 122 144 122 144 0.99
5 11 0.025 3.1 9.8 1.8 1 23 151 173 151 173 0.98
6 11 1.5e-06 0.00018 23.1 1.5 1 23 179 201 179 201 0.99
7 11 0.00028 0.035 16.0 0.7 1 23 208 230 208 230 0.99
8 11 1.6e-06 0.0002 23.0 1.9 1 23 236 258 236 258 0.98
9 11 0.0012 0.15 14.0 0.3 1 20 264 283 264 286 0.93
10 11 2e-05 0.0025 19.6 1.3 2 23 293 314 292 314 0.96
11 11 1.8e-06 0.00022 22.9 1.3 1 23 320 343 320 343 0.97

Sequence Information

Coding Sequence
ATGCGGTCGAGATTGGCAGTGGGCGGGCGGCCAAAGGCACACGCCATGCGTCGGCGACGTGCGTTACTCGCTTTTGTGTGTGCACTGGGCGCAGTGCAAGGGCGTCCTTTCGCGTGCGGGCAATGCCCGGCAGCGTTCGCCCGCCGCCCCTACCTGGACATTCACATGCGCACGCATACAGGCGAGCGGCCCTATCAGTGCGACGCGTGTCTGAAGCGCTTCACGCAGAAGTCCAGCCTCAATATACATAAGAGGACGCACACAGTCCAGGGCAGACCGTTCCAGTGCCTGTCGTGCCCCGCCGCCTTCACCTGCAAGCAATACCTGGAGATACACACGCGCACGCACACCGGCGAGCGGCCCTATCAGTGCGACATCTGCCTGAAGCGCTTCACGCAGAAGTCGAGTCTCAACATCCACAAGCGGACGCACTCAGTGCAGGGGCGGCCCTTCCAGTGCCTGCAGTGCCCGGCCGCCTTCACGTGCAAGCAGTACCTGGAGATCCACAACCGCACACACACCGGCGAGCGCCCCTACCAGTGTGACGTATGCCTCAAGAGATTCGCGCAAAAATCTACACTCAATATACACAAAAGAACGCACACAGTGCAAGGGCGTCCGTATCAATGCATGGAGTGCCCGGCGGCGTTCACTTGCAAGCCGTACCTGGAGATACACATGCGTACGCACACGGGGGAAAGGCCGTTCGAGTGCGATGTCTGTTACAAACGCTTCACGCAGAAATCCACGCTCAACATTCACAAGCGAATTCATACCGGTGAACGTCCTTATGCTTGTGATATTTGTCAGAAACGTTTTGCTGTGAAGAGCTACGTAACAGCGCACAGATGGTCTCACGTGGCCGACAAGCCGCTGAACTGCGACCGCTGCTCCATGTCGTTCACATCCAAGTCTCAGTTCGCGCTGCACATTCGCACGCACACCACCGGCTCCTGCTACGAGTGCAGCGTCTGCGGACGCTCCTTCGTAAGGGACAGCTATCTAATaagACACCACAACCGTGTCCACCGCGAGAACCACAGCAACGTGTCGGCGAACAGCATCGGCACCATCAACAGTGTTGCTACCAACACCAACAACTCTAACAACAGCAACTTTGACTCGCCCGGCGTTTGTGACTTAAGCTTCGTTCCAATGGTGAATCGTTACATGACATCTCAAGGGACCCAAGTGTCCATGCAGGATACCAGCAAAATGTCTGCGATGTCGCCACAGTCTATTGCGTCTATTTCGTCGCCCCCTCCCTCGCATACCCCTACGCCCCAGCCCCAGATGTCTGGTCAGATGCATCTTGCAGACTGA
Protein Sequence
MRSRLAVGGRPKAHAMRRRRALLAFVCALGAVQGRPFACGQCPAAFARRPYLDIHMRTHTGERPYQCDACLKRFTQKSSLNIHKRTHTVQGRPFQCLSCPAAFTCKQYLEIHTRTHTGERPYQCDICLKRFTQKSSLNIHKRTHSVQGRPFQCLQCPAAFTCKQYLEIHNRTHTGERPYQCDVCLKRFAQKSTLNIHKRTHTVQGRPYQCMECPAAFTCKPYLEIHMRTHTGERPFECDVCYKRFTQKSTLNIHKRIHTGERPYACDICQKRFAVKSYVTAHRWSHVADKPLNCDRCSMSFTSKSQFALHIRTHTTGSCYECSVCGRSFVRDSYLIRHHNRVHRENHSNVSANSIGTINSVATNTNNSNNSNFDSPGVCDLSFVPMVNRYMTSQGTQVSMQDTSKMSAMSPQSIASISSPPPSHTPTPQPQMSGQMHLAD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00958832;
90% Identity
iTF_00072255;
80% Identity
-