Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.32 29 6.3 0.8 2 23 87 109 86 109 0.92

2 7 0.0018 0.17 13.4 0.5 2 23 132 153 131 153 0.97

3 7 3.8e-05 0.0035 18.7 0.3 1 23 157 180 157 180 0.95

4 7 0.8 74 5.1 0.2 3 22 188 207 187 207 0.94

5 7 0.0049 0.45 12.1 1.5 1 23 214 237 214 237 0.90

6 7 0.024 2.2 9.9 2.8 1 23 244 267 244 267 0.95

7 7 0.00097 0.089 14.3 2.2 5 23 276 294 270 294 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.32	29	6.3	0.8	2	23	87	109	86	109	0.92
2	7	0.0018	0.17	13.4	0.5	2	23	132	153	131	153	0.97
3	7	3.8e-05	0.0035	18.7	0.3	1	23	157	180	157	180	0.95
4	7	0.8	74	5.1	0.2	3	22	188	207	187	207	0.94
5	7	0.0049	0.45	12.1	1.5	1	23	214	237	214	237	0.90
6	7	0.024	2.2	9.9	2.8	1	23	244	267	244	267	0.95
7	7	0.00097	0.089	14.3	2.2	5	23	276	294	270	294	0.89

Coding Sequence: ATGACTTTTTTTCCTTTTCTAGACGGTACACCGTACTACCTCGTGAGGAGAAACGCCGAGCTTATTATTAAGCATACCACGGCTTATCCGTTCCGCGTCAATCTCAAGTCGTTCCGATGCGTTTACTGCGCAGACTTGATCGATGAACCTGACGAATTTCGTGCACACATGTCCCGGGAACATCAAACATTCACACTAAACATGGCCTTTGTCAAACTACCCAAAACTGAATCAGTGAAAGCTGATATAATGAACTTAAAATGCCGAATTTGCAACCAAAACTGCCCCACTCTGAGAGACGCAGCAATTCATTTGAAGGACACCCATAGTAAAGCTGTCGATCCTGACGCTGATTTGGGAGTTATGCCCTATTTGTTAGAAAAAGACAGATGGAGATGCGCTGTTTGCGAAAAGAGTCTCCCGTCCCTTTTGCACTTAAACAAGCATACTATAACCCATTTCCAAAGCCACATATGCGAAATATGCGGCAAGAGTTACAAAGCTTCTACAGGGCTAGTTCAACACATAAGAGCGAAACACGACGAAGGAAATAAAGCGTTTTGTAGACGTTGTCAAACTGTGTTCCCCTCAATGGAGGCTAAAGCGGTTCACCAACGCACGGAGAAGCGTTGCATGATCCATTGCTGCTTGGAGTGTCCGGAAAGGTTTCCCAGTTGGGAGACTAAGCAGAAACATATGGTTGAAGTGCACGGAATGGAGAAAAAGACGTATCGTTGCACAAATTGCGATTGGGTGTGCGAAGATCGTAGGGCGTTTTACGATCATTTTAAGTTGAGGCATTCTCAGGATTGCCTCTTATGCATTCACTGTGGACTTAAGTTTGCTACTCCGTCGAGGTTGAATAGACATTTAGAGAAACACGTGGCGTAA
Protein Sequence: MTFFPFLDGTPYYLVRRNAELIIKHTTAYPFRVNLKSFRCVYCADLIDEPDEFRAHMSREHQTFTLNMAFVKLPKTESVKADIMNLKCRICNQNCPTLRDAAIHLKDTHSKAVDPDADLGVMPYLLEKDRWRCAVCEKSLPSLLHLNKHTITHFQSHICEICGKSYKASTGLVQHIRAKHDEGNKAFCRRCQTVFPSMEAKAVHQRTEKRCMIHCCLECPERFPSWETKQKHMVEVHGMEKKTYRCTNCDWVCEDRRAFYDHFKLRHSQDCLLCIHCGLKFATPSRLNRHLEKHVA

Sequence clustering based on sequence similarity using MMseqs2