Agen020500.1
Basic Information
- Insect
- Agriphila geniculea
- Gene Symbol
- ewg
- Assembly
- GCA_943789515.1
- Location
- CALSUL010000249.1:1623880-1642467[+]
Transcription Factor Domain
- TF Family
- Nrf1
- Domain
- Nrf1_DNA-bind domain
- PFAM
- PF10491
- TF Group
- Basic Domians group
- Description
- In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human [1]. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila [2]. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0 there is also an NLS domain at 88-116, and a DNA binding and dimerisation domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 20 3.9e-42 5e-38 132.8 0.7 1 78 85 162 85 167 0.98 2 20 1.2e-14 1.5e-10 42.9 0.0 42 78 170 206 166 212 0.95 3 20 1.1e-14 1.5e-10 43.0 0.0 42 78 214 250 209 256 0.94 4 20 1.2e-14 1.5e-10 42.9 0.0 42 78 258 294 253 299 0.95 5 20 1.1e-14 1.5e-10 43.0 0.0 42 78 302 338 297 344 0.94 6 20 1.1e-14 1.4e-10 43.0 0.0 42 78 346 382 340 388 0.94 7 20 1.1e-14 1.4e-10 43.0 0.0 42 78 390 426 384 432 0.94 8 20 1.1e-14 1.4e-10 43.0 0.0 42 78 434 470 428 476 0.94 9 20 1.1e-14 1.4e-10 43.0 0.0 42 78 478 514 472 520 0.94 10 20 1.2e-14 1.5e-10 42.9 0.0 42 78 522 558 518 564 0.95 11 20 1.2e-14 1.5e-10 42.9 0.0 42 78 566 602 562 608 0.95 12 20 1.2e-14 1.5e-10 42.9 0.0 42 78 610 646 605 651 0.95 13 20 1.1e-14 1.5e-10 43.0 0.0 42 78 654 690 648 695 0.95 14 20 1.1e-14 1.5e-10 43.0 0.0 42 78 698 734 692 739 0.95 15 20 1.1e-14 1.4e-10 43.0 0.0 42 78 742 778 736 784 0.94 16 20 1.1e-14 1.4e-10 43.0 0.0 42 78 786 822 780 828 0.94 17 20 1.2e-14 1.5e-10 42.9 0.0 42 78 830 866 826 872 0.95 18 20 1.1e-14 1.5e-10 43.0 0.0 42 78 874 910 869 916 0.94 19 20 1.1e-14 1.4e-10 43.0 0.0 42 78 918 954 911 960 0.94 20 20 3.1e-82 4e-78 263.8 0.0 42 212 962 1131 957 1132 0.97
Sequence Information
- Coding Sequence
- ATGGTCCTAGAGGTGAAGCGCACTCACGACGAAGACAGCGATCCCGACTTCGACATCATGAATTCGGCAGTCAGCACAGAGTCTATTGACATGGCGGAGGAGGACATGTCCCAGGTGGAGGGCTGCGGGCTGAGCGGGTCGGAGGACGACGACGAGTGCGCGTCGTCGCCCGCCGGCTCCGCCTACGACGACCAGCAGGACATGATCAAGAACGCCCTGAGCGACGAGGTCACCAAGCAGCTGGCTGCTGCAGGTCCCGTTGGCATGGCTGCAGCCGCCGCCATCGCCTCCTCAAAGAAACGCAAGAGGCCACATTCCTTCGAAACCAACCCCTCAGTCAGAAAAAGACACCAGAATAGACTGCTCAGGAAACTAAGACAAACGATCGAGGAGTTCGCGACGCGCGTGGGGCAGCAGGCCGTGGTGCTGGTGGCGACGCCGGGCAAGCCCAACACCTCGTACCGCGTGTTCGGCGCCGAGCCATTAGTATATCAGTCGATGTTGTGGCAGCAAACGATCGAGGAGTTCGCGACGCGCGTGGGGCAGCAGGCCGTGGTGCTGGTGGCGACGCCGGGCAAGCCCAACACCTCGTACCGCGTGTTCGGCGCCGAGCCATTAGTATATCAGTCGATGTTGTGGCAGCAAACGATCGAGGAGTTCGCGACGCGCGTGGGGCAGCAGGCCGTGGTGCTGGTGGCGACGCCGGGCAAGCCCAACACCTCGTACCGCGTGTTCGGCGCCGAGCCATTAGTATATCAGTCGATGTTGTGGCAGCAAACGATCGAGGAGTTCGCGACGCGCGTGGGGCAGCAGGCCGTGGTGCTGGTGGCGACGCCGGGCAAGCCCAACACCTCGTACCGCGTGTTCGGCGCCGAGCCATTAGTATATCAGTCGATGTTGTGGCAGCAAACGATCGAGGAGTTCGCGACGCGCGTGGGGCAGCAGGCCGTGGTGCTGGTGGCGACGCCGGGCAAGCCCAACACCTCGTACCGCGTGTTCGGCGCCGAGCCATTAGTATATCAGTCGATGTTGTGGCAGCAAACGATCGAGGAGTTCGCGACGCGCGTGGGGCAGCAGGCCGTGGTGCTGGTGGCGACGCCGGGCAAGCCCAACACCTCGTACCGCGTGTTCGGCGCCGAGCCATTAGTATATCAGTCGATGTTGTGGCAGCAAACGATCGAGGAGTTCGCGACGCGCGTGGGGCAGCAGGCCGTGGTGCTGGTGGCGACGCCGGGCAAGCCCAACACCTCGTACCGCGTGTTCGGCGCCGAGCCATTAGTATATCAGTCGATGTTGTGGCAGCAAACGATCGAGGAGTTCGCGACGCGCGTGGGGCAGCAGGCCGTGGTGCTGGTGGCGACGCCGGGCAAGCCCAACACCTCGTACCGCGTGTTCGGCGCCGAGCCATTAGTATATCAGTCGATGTTGTGGCAGCAAACGATCGAGGAGTTCGCGACGCGCGTGGGGCAGCAGGCCGTGGTGCTGGTGGCGACGCCGGGCAAGCCCAACACCTCGTACCGCGTGTTCGGCGCCGAGCCATTAGTATATCAGTCGATGTTGTGGCAGCAAACGATCGAGGAGTTCGCGACGCGCGTGGGGCAGCAGGCCGTGGTGCTGGTGGCGACGCCGGGCAAGCCCAACACCTCGTACCGCGTGTTCGGCGCCGAGCCATTAGTATATCAGTCGATGTTGTGGCAGCAAACGATCGAGGAGTTCGCGACGCGCGTGGGGCAGCAGGCCGTGGTGCTGGTGGCGACGCCGGGCAAGCCCAACACCTCGTACCGCGTGTTCGGCGCCGAGCCATTAGTATATCAGTCGATGTTGTGGCAGCAAACGATCGAGGAGTTCGCGACGCGCGTGGGGCAGCAGGCCGTGGTGCTGGTGGCGACGCCGGGCAAGCCCAACACCTCGTACCGCGTGTTCGGCGCCGAGCCATTAGTATATCAGTCGATGTTGTGGCAGCAAACGATCGAGGAGTTCGCGACGCGCGTGGGGCAGCAGGCCGTGGTGCTGGTGGCGACGCCGGGCAAGCCCAACACCTCGTACCGCGTGTTCGGCGCCGAGCCATTAGTATATCAGTCGATGTTGTGGCAGCAAACGATCGAGGAGTTCGCGACGCGCGTGGGGCAGCAGGCCGTGGTGCTGGTGGCGACGCCGGGCAAGCCCAACACCTCGTACCGCGTGTTCGGCGCCGAGCCATTAGTATATCAGTCGATGTTGTGGCAGCAAACGATCGAGGAGTTCGCGACGCGCGTGGGGCAGCAGGCCGTGGTGCTGGTGGCGACGCCGGGCAAGCCCAACACCTCGTACCGCGTGTTCGGCGCCGAGCCATTAGTATATCAGTCGATGTTGTGGCAGCAAACGATCGAGGAGTTCGCGACGCGCGTGGGGCAGCAGGCCGTGGTGCTGGTGGCGACGCCGGGCAAGCCCAACACCTCGTACCGCGTGTTCGGCGCCGAGCCATTAGTATATCAGTCGATGTTGTGGCAGCAAACGATCGAGGAGTTCGCGACGCGCGTGGGGCAGCAGGCCGTGGTGCTGGTGGCGACGCCGGGCAAGCCCAACACCTCGTACCGCGTGTTCGGCGCCGAGCCATTAGTATATCAGTCGATGTTGTGGCAGCAAACGATCGAGGAGTTCGCGACGCGCGTGGGGCAGCAGGCCGTGGTGCTGGTGGCGACGCCGGGCAAGCCCAACACCTCGTACCGCGTGTTCGGCGCCGAGCCATTAGTATATCAGTCGATGTTGTGGCAGCAAACGATCGAGGAGTTCGCGACGCGCGTGGGGCAGCAGGCCGTGGTGCTGGTGGCGACGCCGGGCAAGCCCAACACCTCGTACCGCGTGTTCGGCGCCGAGCCATTAGTATATCAGTCGATGTTGTGGCAGCAAACGATCGAGGAGTTCGCGACGCGCGTGGGGCAGCAGGCCGTGGTGCTGGTGGCGACGCCGGGCAAGCCCAACACCTCGTACCGCGTGTTCGGCGCCAAGCCGCTGGAGGACGTCGTGCGCAACCTGCGCTGCATGATCATGGAGGAGCTCGAGAACGCGCTCGCGCAGCAGgcgccgccgccgcccgccgACGACCCCTCGCTGTTCGAGCTGCCGCCGCTCATCATCGACGGCATCCCCACGCCCGTCGAGAAGATGACGCAGGCGCAGCTCAGGGCCTTCATACCCCTCATGCTCAAGTACTCCATGGTCCGCGGCAAGCCGGGGTGGGGCCGCGAGTCCACGCGGCCGCCGTGGTGGCCCAAGGACCTGCCCTGGGCCAACGTGCGCATGGACGCGCGCTCCGAGGACGAAAAACAAAAGATGTCGTGGACGCACGCGCTGCGGCAGATCGTGATCAACTGCTACAAGTACCACGGGCGCGAGGACCTGCTGCCCGCCTTCACCGAGGAGGACGACAAGCCGCCCACGCAGCCCATGTCGCAGTACGCTCCAGcggtgctgcagaccatcacGAACCCGGACGGCACGGTGTCGCTCATCCAGGTGGACCCCAACAACCCCATCATCACGCTGCCCGACGGGACCACCGCGCAAGTGATCCACAGCAGCGAGGGCGGCGGCAGCGTGGTGCAGGCGCTGGACGGCGAGGGCGGCTCCGTGACCGTGGACCTCAACGCCGTGGCCGAGGCCACGCTCAACCACGACGGACAACTCATACTCACCGGCGAGGACGGACACGGTACACGATGCAAAATAGCATACATACACTAG
- Protein Sequence
- MVLEVKRTHDEDSDPDFDIMNSAVSTESIDMAEEDMSQVEGCGLSGSEDDDECASSPAGSAYDDQQDMIKNALSDEVTKQLAAAGPVGMAAAAAIASSKKRKRPHSFETNPSVRKRHQNRLLRKLRQTIEEFATRVGQQAVVLVATPGKPNTSYRVFGAEPLVYQSMLWQQTIEEFATRVGQQAVVLVATPGKPNTSYRVFGAEPLVYQSMLWQQTIEEFATRVGQQAVVLVATPGKPNTSYRVFGAEPLVYQSMLWQQTIEEFATRVGQQAVVLVATPGKPNTSYRVFGAEPLVYQSMLWQQTIEEFATRVGQQAVVLVATPGKPNTSYRVFGAEPLVYQSMLWQQTIEEFATRVGQQAVVLVATPGKPNTSYRVFGAEPLVYQSMLWQQTIEEFATRVGQQAVVLVATPGKPNTSYRVFGAEPLVYQSMLWQQTIEEFATRVGQQAVVLVATPGKPNTSYRVFGAEPLVYQSMLWQQTIEEFATRVGQQAVVLVATPGKPNTSYRVFGAEPLVYQSMLWQQTIEEFATRVGQQAVVLVATPGKPNTSYRVFGAEPLVYQSMLWQQTIEEFATRVGQQAVVLVATPGKPNTSYRVFGAEPLVYQSMLWQQTIEEFATRVGQQAVVLVATPGKPNTSYRVFGAEPLVYQSMLWQQTIEEFATRVGQQAVVLVATPGKPNTSYRVFGAEPLVYQSMLWQQTIEEFATRVGQQAVVLVATPGKPNTSYRVFGAEPLVYQSMLWQQTIEEFATRVGQQAVVLVATPGKPNTSYRVFGAEPLVYQSMLWQQTIEEFATRVGQQAVVLVATPGKPNTSYRVFGAEPLVYQSMLWQQTIEEFATRVGQQAVVLVATPGKPNTSYRVFGAEPLVYQSMLWQQTIEEFATRVGQQAVVLVATPGKPNTSYRVFGAEPLVYQSMLWQQTIEEFATRVGQQAVVLVATPGKPNTSYRVFGAEPLVYQSMLWQQTIEEFATRVGQQAVVLVATPGKPNTSYRVFGAKPLEDVVRNLRCMIMEELENALAQQAPPPPADDPSLFELPPLIIDGIPTPVEKMTQAQLRAFIPLMLKYSMVRGKPGWGRESTRPPWWPKDLPWANVRMDARSEDEKQKMSWTHALRQIVINCYKYHGREDLLPAFTEEDDKPPTQPMSQYAPAVLQTITNPDGTVSLIQVDPNNPIITLPDGTTAQVIHSSEGGGSVVQALDGEGGSVTVDLNAVAEATLNHDGQLILTGEDGHGTRCKIAYIH
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -