Basic Information

Gene Symbol
Tf2-12
Assembly
GCA_949125355.1
Location
OX421287.1:3513598-3522144[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 1.8e-06 0.00013 22.8 0.4 2 23 1147 1168 1146 1168 0.97
2 11 0.002 0.15 13.3 3.5 1 23 1240 1262 1240 1263 0.94
3 11 0.0026 0.19 12.9 2.6 1 23 1267 1289 1267 1289 0.98
4 11 0.0023 0.17 13.1 2.4 2 23 1308 1330 1307 1330 0.94
5 11 0.0007 0.051 14.7 2.7 1 23 1334 1357 1334 1357 0.98
6 11 0.0066 0.48 11.6 0.6 2 23 1380 1402 1379 1402 0.90
7 11 2.1e-05 0.0016 19.5 3.8 1 23 1412 1434 1412 1435 0.96
8 11 0.015 1.1 10.5 1.0 3 23 1452 1472 1451 1472 0.98
9 11 0.043 3.1 9.1 1.7 1 23 1478 1500 1478 1500 0.95
10 11 0.51 37 5.7 4.6 1 22 1506 1527 1506 1530 0.90
11 11 0.0026 0.19 12.9 0.0 3 23 1583 1603 1581 1603 0.97

Sequence Information

Coding Sequence
atggcGTATACTATAAAGTTTCTTTCTTTGCAAAAATCAGAATTGGAATACGAGGTGGAGCTTCGGGGTGGCGTAGGTGACTCAGTACAAGAGCTGAGAAAACAGATAGTTAAGTTATCTCAACAGTTGCCCTCCGAAGATATTTTAGAGTCCTACTTAGAGCCTGCTGATGATCTAAAAGGGGTTAAAGAGTCTCTTATTAAATCACAGGGATATCAACTAGAAACTTGCGACACACCTAGATTCGTAGCTGCCGGTGGTGAAAAACTAAACTCTGCCGGAGTTATTCACCTACCAATAACCTTCGAGGACCAGACTCACACTCTTCAAGTCTACATTATACCTAATGTAAAGCACGATCTAATATTGGGAATGGATTTTTGGCGACTCTTTGGACTTCTCCCCAAAAATTTAGATCGCATTGCCTTTTATAAGGAATCGGAAAAAGTCTATCTGACCGATATTGAGCACGAAAAGTCTAAACTATTGTGTTCTTACGATCACTTAACCGAGGAACAAAAGTCAATAGCGGACAGTATAATATCGCAGTTTCACGACATTTCCTATGAAAAGCGTGGCCTAGGTCGCACTACCTTGACTACCCATACAATTGACACTGGGGATGCTGCCCCCATTCGTCAACGCTACTATCGAATGTCACCTGAAAAGCAACGCATTCTTGTTGAACAGTTAGACGAGATGCTGAAGGAAGACATCGTTGAACCCTGCGAGAGCCCGTGGTCATCTCCTGTTCTACTAACCCCGAAAAAAAATGGAGAGATGCGATTCTGCCTTGACAGCAGGAAACTAAATGCCATTACCAAGAAGGATGCGTATAGTCTACCCTATATCGCTGAGATTCTCGATAACCTTCGTGATGCGAAATTTTTATCAAGTATCGATCTCTCTAAAAGTTTTTGGCAAGTCTTGATTAAGGAGAAGGATAGACAAAAGACCGCATTCTACATTCCTACCCGCGGCACCTTTCAATTTAAGTCTATGCCTTTTGGACTTACTAATGCGCCGGCTACGCAACAAAGATTAGTGGACAACCTATTCTATGGACCGGAGTTCGAACACAGGGTGTTCGTTTTCGtcgatgacgtcatcattgtcTCCGAAAGCTACGAACGCCACATGTCCTTACTAAACCTTGTTCTTGAAAAATTGAAAACTGCAAATCTGACTATAAACTATGAAAAGAGTCAATTTTTTCGGTCGCAACTCAGATACCTTGGCTATATAGTAGATTCAGACGGCCTTCACGCAGACCCTGAAAAAGTGGAGTCAATTGTGAAGTACCCTACTCCTACAAATCGGAAGGAAGTTAGGCGATTCATAGGTACTGCATCTTGGTATCGCCGATTTATTTCCAACTTCAGTACACTATCCGCTCCACTAAATAAACTCACATCACAAGGCAAAAATGCTCTACCTTTTATATGGTCCCCAGAAGCTAACAAGGCATTCGAGGAACTTAAAAAGTGCCTTGTCTCAGCGCCTATACTTTCGTGCCCTGACTACTCAAAACCATTTGAAGTACACACTGACGCAAGTGATTATGGTCTTGGTGCGGTGCTCACTCAGACACTAGATGGGCAGGAAAAAGTCATAGCGTACATGAGCAAATCCTTGTCGCAGCAAGAGCGGAACTATAGTGCCACGGAACGCGAGGCGTTAGCAGTACTCATTGCAATCGAGCATTGGCGTTGCTATATTGAAAACGGCCTTAAGTTTACTGTCTTTACTGACCACTCCTCTCTTAAGTGGTTTTTAAACTTAAACAATCCTACTGGGAGACTGGCTCGATGGGGTGTACGCCTATCTGCATTCAACTTTGAAATTAAGCACAGAAAAGGCACCGAAAACGTTGTCCCAGATAGTTTGAGTCGCTCTGTTCCAATTACGGCCATTGACACTGTACTGGACAACCCGGCTAAGAAAACTAACGACGTCTGGTACCTCTCTATTTTTAACGGATGCCAGACTTCCCCTACGTCTTTTCTAAACTATCGCGTTACCAATGGTTTACTCTTTCGCTACATGAAATCTCTTAACCCACTAACTAGAGAGTTCGAATGGAAAGAGGTAATTCCAACGGAATACCGACAGGAAATTATCTCCAAAAACCATTCGGAACCTACGTCTGGCCACTTTGGCATTTTCAAAACACATAAGCGTCTTAGCCTAAAATATTTCTGGCCTAGCCTACATAAAGATGTCATAAATTTCATTACAACTTGTGAAACTTGCCTATCATACAAATATCCAAACCACTCTACCCTTGGGACAATGGGTAGACCAAAGGACTGCTGCCGTCCTTACCAAATGTTGAGTATGGATTTGGTCGGTCCCTTGCCAGTTTCCCGAAAGCAGAATACCTTTCTGCTTGTAATTACTTGTTGCTTCTCGAAATACAGCTTGCTCTTTCCCATACGAAGAGCAACTTCCGATATCATATCCAAAATCTTGGAAGAACGAGTCTTCCTTGTCCATGGTATCCCTAGTACAATACTTATGGATAACGGAAAGCAGTTTACTAGTAATATCATGCGTGACTTGTTTGCTTCCTACAATATTCCTAACGTGTACTACACTCCACTATATACGCCTCAGGTAAACACAGTTGAACGttacaataaaactataattactgCTGTGTCCACCTTTATCGAGAACGACCATAGGTCATGGGACGCCAACATCGCTAAAATACAATTTGCCCTGAACAGCGCAGTAAATGAAGTAACAGGATACACCCCATCATTTCTCGTTTTTGGACGAGAGTTGATAAGTGACGGTTCGCATTATATTGATCCAGATTTAGGAAATCAAATTGTGTTTGTCCCTCGTGATAGCTACGTGGAGAATCTAGGTGTGCTACAGAAAATTTTCGATAAAGTGCAGCTAGCACTTCTTAAAGCACACTCTCGAAATAGTGCAAATTATAATCTACGCCGTAAAAAAGTTGAGTTTAACGTTGGAGACATAGTTTGGAAGCGAACATTCTTTCAGAGCAGTAAGGATAACAAGTTCACAAAAAAATTAGCTcctaaatttgtaaaatgtcgCATCGACCACCAGAAAGACTTCCCAAGAATCATCAAAGACGAATCAGAACTGACCGTCACAGAAACACACTTGATCTCTAACAAATTCATCAATACAACTTCCACTATCACCAGTACACATGATGGCGTCATCGCGTCGCAGACAACTAAGACTTTGATCATGGAAATCCATCCCATGACCCGCGAGAACCAAGCCTTGAAGATGGGCAACCCAGAGGAAATCCTACCAACCAGCAAAGAAACTTACGAAATGGACTGCGAACCTTTCCAACTAAATTCAATCACTGGAAACATTTTATCTTTAGAACAAGAGGCATATGGCTTGTTAAAAACGAAGATAAAGAAAAAGTCATCGACAGTGGAAATGGTCTGCCCAAAGTGTCCGAAAGTGTTCAATCAGAAATTTGCTCTGAACAGGCATCTAAAAGTTCATGACTCAATTGAGAAACGAGCGAATGGAGTCCTCAAAGGCCTTAAAACGAGGAtggagaaaaagaaaataaaagaagaagATATAAAGAAAAACTTACCTGTAAAGAAGGAAGAAAAAACAGGTTATCAATGTACCTGTGGTAGCACATTTCAAAGACGAAGTCGTATGGAAACCTGTCTCAGGTCGCACACCGAGTACGCTGACACTAGTTCCTACGACTGCCCGACTTGCGACAAGAAATTCAAGTCGAAAGAGCTGCTAATCTTCCACCGGCAGCGACACCATCGCAAGAAGTTTCCATGCAAATTCTGTCCAACAGACTACCACACGCAAAAAGCACTCTTCAAACATCTGCGAATACATCAGAAAGTTCAACTGACAGAGTACAAAATCATAGCTGAAGGAAACCAGGATCTGAAATGCTTGCTCTGCAAAAAAACCTGCTCCAAGCTTTCAGATTTAAAATCGCACATTATGGAAGATCACAGGGAACCGTACAAATGTCCACACTGCAAAgaaaagtttacaaaaatagAAGATTTCGCAATTCACTTAAAGAAGACCCACCCCGATGTTGGAGACCAGTCGGTTTTGGACGTCCTCGAAGCGTTTTCGAAGTTGGTCAAAGCGTGGAAGTGTGAAAATTGCGGGAAACAGTTCCACAAGGCCGATAAGTTGGCGTTGCACCAGGTAGAAGAGCACAGTCCAGACATGAAGAATGAACAACACTTTCAATGCGGTGACTGCCAAAGGGTATTCATTAGTAAGTGTGGACTTAACTCTCACATGAGGATGCATCATAGAACAGAGAGTGCCGAGGAGCCAGAACCTGAAGAAGTAGGTGTCTTATGTTTGGAATGTCGTAAAGTATGTCCGGACATGAACGCCCTGACATCACACATGCGTCTACACTCCATGGACAGAAAATACCCATGCAAGTTCTGCGACTTCCGCTTTGCAACGCCACAGAAGCGAAAAAAACACTCAGAAATACATACAGGTGATATGAAATACGTCTGTTTCATATGCGAATACACATGCAGTTCTGAAAACCGTCTCAAACATCATAAAATGTCCATCAAACATGCTAACATGAGAGAATACCTTCTAACTGGCAAGCCGTTAATAGAAGAAGAACAATCAACATCCAAAAAAGAGAAGATTAAAGATACGTTGAGGAAGAAAGAGTGGGGGGTtaaaaagagaaagaaagaaaagaaagagaaGGAGGACGATATTGCTTGTGATATTTGTGGGGAAAAGTTCGCAACGGAAGGAGAAATGTTGGAACATAAGCAGACACATCCTTTTATTGAATTCCCTAACGATGATAAACCTAGTagaatattttttaagtga
Protein Sequence
MAYTIKFLSLQKSELEYEVELRGGVGDSVQELRKQIVKLSQQLPSEDILESYLEPADDLKGVKESLIKSQGYQLETCDTPRFVAAGGEKLNSAGVIHLPITFEDQTHTLQVYIIPNVKHDLILGMDFWRLFGLLPKNLDRIAFYKESEKVYLTDIEHEKSKLLCSYDHLTEEQKSIADSIISQFHDISYEKRGLGRTTLTTHTIDTGDAAPIRQRYYRMSPEKQRILVEQLDEMLKEDIVEPCESPWSSPVLLTPKKNGEMRFCLDSRKLNAITKKDAYSLPYIAEILDNLRDAKFLSSIDLSKSFWQVLIKEKDRQKTAFYIPTRGTFQFKSMPFGLTNAPATQQRLVDNLFYGPEFEHRVFVFVDDVIIVSESYERHMSLLNLVLEKLKTANLTINYEKSQFFRSQLRYLGYIVDSDGLHADPEKVESIVKYPTPTNRKEVRRFIGTASWYRRFISNFSTLSAPLNKLTSQGKNALPFIWSPEANKAFEELKKCLVSAPILSCPDYSKPFEVHTDASDYGLGAVLTQTLDGQEKVIAYMSKSLSQQERNYSATEREALAVLIAIEHWRCYIENGLKFTVFTDHSSLKWFLNLNNPTGRLARWGVRLSAFNFEIKHRKGTENVVPDSLSRSVPITAIDTVLDNPAKKTNDVWYLSIFNGCQTSPTSFLNYRVTNGLLFRYMKSLNPLTREFEWKEVIPTEYRQEIISKNHSEPTSGHFGIFKTHKRLSLKYFWPSLHKDVINFITTCETCLSYKYPNHSTLGTMGRPKDCCRPYQMLSMDLVGPLPVSRKQNTFLLVITCCFSKYSLLFPIRRATSDIISKILEERVFLVHGIPSTILMDNGKQFTSNIMRDLFASYNIPNVYYTPLYTPQVNTVERYNKTIITAVSTFIENDHRSWDANIAKIQFALNSAVNEVTGYTPSFLVFGRELISDGSHYIDPDLGNQIVFVPRDSYVENLGVLQKIFDKVQLALLKAHSRNSANYNLRRKKVEFNVGDIVWKRTFFQSSKDNKFTKKLAPKFVKCRIDHQKDFPRIIKDESELTVTETHLISNKFINTTSTITSTHDGVIASQTTKTLIMEIHPMTRENQALKMGNPEEILPTSKETYEMDCEPFQLNSITGNILSLEQEAYGLLKTKIKKKSSTVEMVCPKCPKVFNQKFALNRHLKVHDSIEKRANGVLKGLKTRMEKKKIKEEDIKKNLPVKKEEKTGYQCTCGSTFQRRSRMETCLRSHTEYADTSSYDCPTCDKKFKSKELLIFHRQRHHRKKFPCKFCPTDYHTQKALFKHLRIHQKVQLTEYKIIAEGNQDLKCLLCKKTCSKLSDLKSHIMEDHREPYKCPHCKEKFTKIEDFAIHLKKTHPDVGDQSVLDVLEAFSKLVKAWKCENCGKQFHKADKLALHQVEEHSPDMKNEQHFQCGDCQRVFISKCGLNSHMRMHHRTESAEEPEPEEVGVLCLECRKVCPDMNALTSHMRLHSMDRKYPCKFCDFRFATPQKRKKHSEIHTGDMKYVCFICEYTCSSENRLKHHKMSIKHANMREYLLTGKPLIEEEQSTSKKEKIKDTLRKKEWGVKKRKKEKKEKEDDIACDICGEKFATEGEMLEHKQTHPFIEFPNDDKPSRIFFK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-