Basic Information

Insect: Agrilus cyanescens
Gene Symbol: Hsf
Assembly: GCA_947389935.1
Location: OX376704.1:6439055-6453762[-]

Transcription Factor Domain

TF Family: HSF
Domain: HSF_DNA-bind domain
PFAM: PF00447
TF Group: Helix-turn-helix
Description: Heat shock factor (HSF) is a transcriptional activator of heat shock genes [1, 4]: it binds specifically to heat shock promoter elements, which are palindromic sequences rich with repetitive purine and pyrimidine motifs [1]. Under normal conditions, HSF is a homo-trimeric cytoplasmic protein, but heat shock activation results in relocalisation to the nucleus [2]. Each HSF monomer contains one C-terminal and three N-terminal leucine zipper repeats [3]. Point mutations in these regions result in disruption of cellular localisation, rendering the protein constitutively nuclear [2]. Two sequences flanking the N-terminal zippers fit the consensus of a bi- partite nuclear localisation signal (NLS). Interaction between the N- and C-terminal zippers may result in a structure that masks the NLS sequences: following activation of HSF, these may then be unmasked, resulting in relocalisation of the protein to the nucleus [3]. The DNA-binding component of HSF lies to the N terminus of the first NLS region, and is referred to as the HSF domain.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 8.4e-29 4.2e-24 86.4 2.0 20 100 224 304 207 304 0.90

2 3 0.35 1.8e+04 -2.2 0.0 16 45 551 581 543 588 0.75

3 3 0.15 7.8e+03 -1.1 0.0 48 60 732 744 713 791 0.55

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	8.4e-29	4.2e-24	86.4	2.0	20	100	224	304	207	304	0.90
2	3	0.35	1.8e+04	-2.2	0.0	16	45	551	581	543	588	0.75
3	3	0.15	7.8e+03	-1.1	0.0	48	60	732	744	713	791	0.55

Sequence Information

Coding Sequence: ATGACTCCCGACCAGTTGGAAACGTCTTCTCAATATTTCGAAAACTGCCAAAATTCTTACATAGAACTAGAAACGTTTGAAGATTTCAATTTAAATTGCAATCCCATCAGTGAACAAGCCAATATCATCAGATGTGCACCTGAAAACAGTGATATACTCTCCGAAGCAAACGATTTTTTTAATTTGGAATGTAGAAGTGATAACATATTCGAAAGTTTCGGTGCCACCGAAGATAATGTTTCCTTGAAAAAGTTTTATGAAGAATGTTATTTTGATGATTCGAACGTCTTGTGCTGCGAATTAATGGACAAGAATACTGCGAATAATGAAGAGGACAATCCTTTTTCTGTGCTAGGTATCAGCCTAGATCTGGGCTTATCGGAAGATTCGTATCTACTGAAGAACTTCGATACAGAGTTAGATCAGTTACTAGACGAAAACTTCTTCAGCACGGGAAATTCCCTAATATTCGGCGATAACTTTGACAAAACTAGATCGGAGTTTAGCCTCATTCAAACTAAGGAAAACGAAAAAGATGCCACTCAAGAAAATTTGGACACAGACAAAATTATTAACATGTTTCCTCATATGCACGACGAAAGGAACAGAAGAAGACGATATTTATTGTACGAAAACTCTCAGGCAAATAAAAAAGGTCAACAAATGGTCAAGTCTCCGACTGGAAATAGTTTTATCATCCAAAATCAAGCGCAGTTTTGGTATGATCTTCTACCTGTATACTATAAGCATAATAACATGAGTAGTTTTGTACGGCAACTTAATATGTATGGATTTCATAAGATAACAACCGTTGAAAATGGTACAATGGATATTGATAAAGATGAAATACAATTTTATCATCCGTTTTTTCAAAGAGATCAACCTGAAATGCTGCGAGAAATTAAGCGAAAGGTAACTACCACCAAGACTTTGGCACCAGAAGGTTATATACAGAGCTCAATAAAAACTGATGTCAATAAAGTGTTAGCGGATGTAAAACAATTAAGATCCCATCAACAAACGGTAGATTCACAGTTGTCTTCAATTAAACAAGAAAATGCTGTTCTATGGCGAGAATTAGCCATGCTACGTCAGAAGCATATGAAGCAACAACAAATTGTTAACAAGCTCATCCAATTTTTGGTAACGATAGTTCAGCCCTCGAATAGAATGAGTGGCCTTGGGGTTAAGCGACGCTATCCATTAATGATACACGGCACTTCACATAAAAAATCGAAAACGAAAAATTCAAGGGCAACCTCTGTTGGCCCAACAATTCATGAAGTTTTATCTGATGATTTATTTGAAGTTTCAGATGACACTCAACAACAGGTACAAAGCCCTACATCTAACGAAAATCCTCAAACTCCGCCCAATAATTTGTTTGATGATGTAAACATCAACAGCGTGGGGCCTGTCTCCCCAGATATTTTCTTAAATTCGCCAGAATTGGAATATCAGCCGCAACCTGAAGATAAACCGGAATATATATCAATTGATGAATTTCTTGACGATCCCACCCCTCAAGCAAACGATAACGTTGCTGTTATCGATAGTTTGCAAAAAGCAGTTACAGAAGAGATTGAAGAATCAAACGAATCTTCAAACAAGGTGTTCCTAAACCCGTCTGCTCAGGATGCACTCCTTTGTAACCTTATAAGTGGAAGTTACAACACAAATAGTCTCAAAGTACAGGAAAAAGACAAAATACCTAAAAAAAGTTTAAAAGAAAAAAACTACTCAACAAATTCAGCGGACCAATTGGCAACAGAGGCTATAAATCAACTCGATGTTGAAGACAACAATATGGCAATTGCTACCAGAGATTCTCCAAGCGGAAATGATTACAAACGATTGACCATCGAGGAACTTGACGAACACCTACAAACCACCCAGAGCGAATTGGATCAACTAAAAGATGTCTTAAATGGATGTGGAACGTTTGATGCAAACGCGTTACTCGGGCTGTTCAATGATCCGCCGTCATATTCTTTATCATTTGGAAAAAATAAGGAGAATCCTGAAGGAGGAGAATTGGCAGAGGTAGGCAACGAACTAACTGCTTACGGCTCCGATATAATAGATTTCAATGAACTTTTTGATGATGCTGAGCTTCAAGATCCTGTAAGTCAAGATGAATGGACATCAAATACGAAAGATGTTATTTTGAACAATGTGCAAAACTTATCAAATATATTTGAGTCATTTTTACCTCAACTTCTTACATATCCTAATCCAATTGATCCCCTTAATGGTGATGCAGCTGCCATGTATCTTCACAAGCCAGAAGAATATAAGAAAAAAGTTTCAGAATATGTGAAAAAATACGCAACTGAAGAAGCATTGCGGGGCCAAGAAAATAATGTAAGTTCTGAAAGTGAATCGAGTATGTCAGATTTTTCAGAAAATGAAGCAGAAGATATGGAGTTATAA
Protein Sequence: MTPDQLETSSQYFENCQNSYIELETFEDFNLNCNPISEQANIIRCAPENSDILSEANDFFNLECRSDNIFESFGATEDNVSLKKFYEECYFDDSNVLCCELMDKNTANNEEDNPFSVLGISLDLGLSEDSYLLKNFDTELDQLLDENFFSTGNSLIFGDNFDKTRSEFSLIQTKENEKDATQENLDTDKIINMFPHMHDERNRRRRYLLYENSQANKKGQQMVKSPTGNSFIIQNQAQFWYDLLPVYYKHNNMSSFVRQLNMYGFHKITTVENGTMDIDKDEIQFYHPFFQRDQPEMLREIKRKVTTTKTLAPEGYIQSSIKTDVNKVLADVKQLRSHQQTVDSQLSSIKQENAVLWRELAMLRQKHMKQQQIVNKLIQFLVTIVQPSNRMSGLGVKRRYPLMIHGTSHKKSKTKNSRATSVGPTIHEVLSDDLFEVSDDTQQQVQSPTSNENPQTPPNNLFDDVNINSVGPVSPDIFLNSPELEYQPQPEDKPEYISIDEFLDDPTPQANDNVAVIDSLQKAVTEEIEESNESSNKVFLNPSAQDALLCNLISGSYNTNSLKVQEKDKIPKKSLKEKNYSTNSADQLATEAINQLDVEDNNMAIATRDSPSGNDYKRLTIEELDEHLQTTQSELDQLKDVLNGCGTFDANALLGLFNDPPSYSLSFGKNKENPEGGELAEVGNELTAYGSDIIDFNELFDDAELQDPVSQDEWTSNTKDVILNNVQNLSNIFESFLPQLLTYPNPIDPLNGDAAAMYLHKPEEYKKKVSEYVKKYATEEALRGQENNVSSESESSMSDFSENEAEDMEL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -