Basic Information

Gene Symbol
su(Hw)
Assembly
GCA_947534325.1
Location
OX384045.1:5847990-5852924[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.00078 0.11 14.4 0.5 2 20 134 152 133 154 0.95
2 13 0.008 1.1 11.3 1.1 1 23 189 212 189 212 0.97
3 13 1.5e-05 0.0021 19.8 2.3 2 23 217 238 216 238 0.96
4 13 0.0015 0.21 13.6 1.1 3 21 245 263 243 264 0.86
5 13 2.2e-07 3.1e-05 25.6 0.4 1 23 275 297 275 297 0.98
6 13 9.6e-06 0.0014 20.5 0.2 1 23 307 329 307 329 0.99
7 13 9.5e-06 0.0013 20.5 0.9 1 23 335 357 335 357 0.98
8 13 9e-05 0.013 17.4 1.0 1 23 363 385 363 385 0.99
9 13 1.3e-05 0.0018 20.0 3.5 1 23 391 413 391 413 0.95
10 13 2.3e-05 0.0032 19.3 1.6 1 23 419 442 419 442 0.96
11 13 9.6e-06 0.0014 20.5 0.9 1 23 448 470 448 470 0.94
12 13 1e-06 0.00015 23.5 4.5 1 23 476 498 476 498 0.98
13 13 5.2e-07 7.3e-05 24.4 1.8 2 23 505 527 505 527 0.97

Sequence Information

Coding Sequence
ATGTCAGAAGCAAGCGAAGGAACCGAGGTTAAGCAGGAGCTAAAAACCGAAGCCGTTACTTACGAAACGGGCACCACAATCCTAGCAGACATTCCAATCGGCGAACCGATTAACCTCCAAGATGCAGTTGTCATTATACCTGAAAATTCAGAGGGCCAAGTCCTACAAACTGTCCACCAAGCAGACAATGTTGTCATTCTTGCCAGAATGACACAAAATGGAGAGTTAATCACTCCAGATCTAGAGGCAGTTGAAGCTGAAGAAGGTATTGAAGATGTTGAAGACATGGAAGATGTTGAAGAAGGAGATGTTAAGCCCGGCCCTTCTGGAGAGAATGATGAAAGCTATGAAGATGTAGAAGAGGTTGTAGAAGAAGAACCTCTTGAATTGGAACCAAATCAATGTTCGTTTTGTCGAAAAGTCTTCAAGTCCACAACGGGTCTAAAACGCCATCTAATCGCATGCCAACCAGATCCGTCCGATGACGAACAAGACGACCCATTGGCGTTTGAAATATGTCACTGCTGCAGTGAACCCTTAGACACCGCTCACAAAGTGGGCGATTTTTGCTGCTCCCAATGTGAAAAGCTGTTTGTAAGCGAGAATGCTCGGGAGCGGCATATTCGTATAGTTCACAGTGATGGCTTGACCTGTCCTGACTGCGATAAAAAATGCACGAGCCGCCGGGAACTAGAGAAACACATCTTCATGCACATGGAGAAACCTTTTGCTTGCATCAGGTGCAATAAGGTCTTCACCAGGAAGTATCATTTGGACCGCCACGTGCAGCAGACTGGATGTGATGGCAAGCCACGGGCCCAGTTTCAATGCCAGGTTTGCGACAAGATTTTCGCTCGACGGGATAATCTCCGTGACCATCTCCGAGCGCACGCTGGTCATGTAAAACGTAAGAAGGTCTTCGAGTGTCCTGATTGCAACAAGGAGTTCCATGGTGCTGCTTTATTGGCTATTCACCAAAGGACCCACACAGGAGAGAGGCCGTTTCAGTGCACCATGTGCCCTAAAAGGTTTCCCTCTAGTGGAGCGATGAAGAAACATAGTAGGATGCATACTGGGGAAAGGCCGTATGAATGCGGGACTTGTCACGCGCGATTTGCAGCAAAAGAAACCCTCAACCGCCATGTTCGCACTCACACGGGGCTCAAGCCGCACTCCTGTCAATTTTGCGGCAAATCTTTCATCCAAGCATCGCAGTTACGAGCGCACATCTTCCATCATACTGGTGAAAATGGCTTTACTTGCGACCATTGCGGCAAAGCGTTCAACAGACGGGCTAGACTTGTCACTCACGTGAAGTATGTCCACGAAGGAGCCGTTCCTTTCGAATGTAATACCTGTAAGAAGACCTTTGTAAGGAAGGAAGACTTGGCCAGGCATTCTATACTACACAGTGGCATCAAACCCCATGAGTGCGATATCTGCCACAAATCCTTCGCAATGAAGTCATCGCTAAAAACACACATGAACACACATCGCAAAGAGCAGCCCCGTTCGTGTGATGAATGCGGTCGGGCATTTATTCGCCAAGATTGTCTTATCCGCCATATGCGAACCAAACATCGGGATCAACTTGAAGACATCTTAGCTGGTGCAGAAAAAAAACGTCTTCAGCAACAACTTCTAGCAGCAGCATCAGAAGCTGCAGGAGAAGAAAAACCCAGCATCGCCGAAAGCGGCGTCTGGTCTGAGTTGAGCTTAACTGATTCCATCAAAGAGCTTTTAACACTCCTGGTCGATGAAGCTACATTGAAAGCTTTTGGATGGCCTGATACTCCAGTAGATAAACTCTTGGATTCGGTTATAAGACGATGCGGGCACAAACCTGCGTCTCAGGAAGATTTCGATTATATTGGACGATTGAGGGAAAATGCTAAGCTACTTTTTACTGTAGTTATTGATGATGCGGCAGTTAAAAGTTTGCTGAATAATCAAACTGTTGATGAAGTTATTTTGCATGTTTTGCGTTTGGCGAAAGCTGAATGA
Protein Sequence
MSEASEGTEVKQELKTEAVTYETGTTILADIPIGEPINLQDAVVIIPENSEGQVLQTVHQADNVVILARMTQNGELITPDLEAVEAEEGIEDVEDMEDVEEGDVKPGPSGENDESYEDVEEVVEEEPLELEPNQCSFCRKVFKSTTGLKRHLIACQPDPSDDEQDDPLAFEICHCCSEPLDTAHKVGDFCCSQCEKLFVSENARERHIRIVHSDGLTCPDCDKKCTSRRELEKHIFMHMEKPFACIRCNKVFTRKYHLDRHVQQTGCDGKPRAQFQCQVCDKIFARRDNLRDHLRAHAGHVKRKKVFECPDCNKEFHGAALLAIHQRTHTGERPFQCTMCPKRFPSSGAMKKHSRMHTGERPYECGTCHARFAAKETLNRHVRTHTGLKPHSCQFCGKSFIQASQLRAHIFHHTGENGFTCDHCGKAFNRRARLVTHVKYVHEGAVPFECNTCKKTFVRKEDLARHSILHSGIKPHECDICHKSFAMKSSLKTHMNTHRKEQPRSCDECGRAFIRQDCLIRHMRTKHRDQLEDILAGAEKKRLQQQLLAAASEAAGEEKPSIAESGVWSELSLTDSIKELLTLLVDEATLKAFGWPDTPVDKLLDSVIRRCGHKPASQEDFDYIGRLRENAKLLFTVVIDDAAVKSLLNNQTVDEVILHVLRLAKAE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01226027;
90% Identity
-
80% Identity
-