Basic Information

Insect: Agelastica alni
Gene Symbol: topi
Assembly: GCA_950111635.2
Location: OX467717.1:26491848-26494463[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 14 0.89 2.2e+02 4.3 1.1 1 21 260 280 260 281 0.91

2 14 0.096 23 7.3 2.0 2 23 290 310 289 310 0.95

3 14 0.0028 0.68 12.1 2.8 1 21 327 347 327 348 0.96

4 14 9.1e-05 0.022 16.8 1.1 1 23 391 413 391 413 0.97

5 14 0.086 21 7.5 4.3 3 23 422 443 421 444 0.96

6 14 0.0035 0.85 11.8 4.6 1 23 448 470 448 470 0.97

7 14 0.00026 0.063 15.4 0.8 1 23 476 499 476 499 0.94

8 14 6.6e-05 0.016 17.3 1.0 1 23 505 527 505 527 0.98

9 14 2.7 6.6e+02 2.8 0.2 3 13 540 550 538 552 0.85

10 14 0.0006 0.15 14.2 6.8 1 23 588 610 588 610 0.98

11 14 1.8e-05 0.0044 19.0 0.3 2 23 619 640 618 640 0.96

12 14 3.5e-06 0.00087 21.3 3.9 1 23 646 668 646 668 0.99

13 14 9.4e-06 0.0023 19.9 2.1 1 23 674 696 674 696 0.98

14 14 3.2e-06 0.00078 21.4 1.1 1 23 702 724 702 724 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	14	0.89	2.2e+02	4.3	1.1	1	21	260	280	260	281	0.91
2	14	0.096	23	7.3	2.0	2	23	290	310	289	310	0.95
3	14	0.0028	0.68	12.1	2.8	1	21	327	347	327	348	0.96
4	14	9.1e-05	0.022	16.8	1.1	1	23	391	413	391	413	0.97
5	14	0.086	21	7.5	4.3	3	23	422	443	421	444	0.96
6	14	0.0035	0.85	11.8	4.6	1	23	448	470	448	470	0.97
7	14	0.00026	0.063	15.4	0.8	1	23	476	499	476	499	0.94
8	14	6.6e-05	0.016	17.3	1.0	1	23	505	527	505	527	0.98
9	14	2.7	6.6e+02	2.8	0.2	3	13	540	550	538	552	0.85
10	14	0.0006	0.15	14.2	6.8	1	23	588	610	588	610	0.98
11	14	1.8e-05	0.0044	19.0	0.3	2	23	619	640	618	640	0.96
12	14	3.5e-06	0.00087	21.3	3.9	1	23	646	668	646	668	0.99
13	14	9.4e-06	0.0023	19.9	2.1	1	23	674	696	674	696	0.98
14	14	3.2e-06	0.00078	21.4	1.1	1	23	702	724	702	724	0.98

Sequence Information

Coding Sequence: atggtTTTAGATGCGGCTTgcctaaaaaaattggaaataattGATGAAGAAAAAAATCGAATAAGTATTACTTTGGAACAGCTAAAGCACAAATGCCGTACTTGTCTATTACGTGATGGTCTCATTAATGTATTTACAACCCAGCACAAAGAATGTTTATTTAGTGATTTATTTGATTGGTTCTCCTTAACCAAAATGTCCCGGTATGATGGTCTGCCACAAAAAATATGTGGTGTTTGTGCAAAATTCATTATGGATTTACATACTTTTAAGCAACAAATTCAGAAGTCATTAATAACATTTCAATTTGCCCTTGGTAAACATGAGAACTTAAGTATTTTTCAAGTAAATGATCTAAAAGTTATTCAGGATAATGATAAGACTACtgatattaaaactgaaacatTAAATGATAGTGACACTGGAGAAGTGCAAGATAATAATGAAGATATGGGCTTTAGTAATAATTTGAATGATGAAACAATAGATAGTGATTGTGGATATTCCAGTAACACAAAAGAAGTTAACAGTAAAAATGGCGATTGTAAGATTAAAAGAAACACtaattttaatgatgaaaacTCTGAAAATGAGAGTACCATAAGTGCTTGTGAAGATACTGAAGAACAAATTAATGAaaAATTAATAGAGGAATTGGATGATACAGAAATTGAAGAAGATTCAACCAACATTATTTTAGATCACAGTTACGTCAAACCAAAATCTCTTGTTGAACTAAAATCTTCAGCTAATGATGCAGATATTTtgggtaaaaaatataaatgtgaagtttgtaaaagtatatttaatgaaagattaaaatttcttaatcatAAGAAAAGTGAAATGGAGGAAAGACGGTTAATGAAGTGTCCCATTTGTCAGAAGAGTGTACAAAGATTCAAGATGGAGGAACATATGCATTTACATTTACAAACAAACAATGATGACTCAGCTGTGCCCTCCAAAATTACAGATTACACTTGCAGTTTTTGCAACGTCAAGTTTTCAACGAGAAAACAGTATCTCACTCATAGAAGACAGGaacagaataaaataaaaacacagaaTAATAAAAGAACCGCAAAAGTTCCTTGTCCTCTCTGTAGCAAGctgattaataaatataaaatgaattttCATCTAAGCACTCATTCAACAGAAAAGCCTTACATGTGTGACATCTGTGGTAAAAAATTAAGGTCGAATAATTccttaaaaattcataaatatagtcacaCTGAAGAGTTGCCAGAGGTTTTGTGCGAAGTTTGTGGAAAGGTATTTAAATGcctaaacaaattaaatgatCACAAGAAGAAAATACATCATGTTAAATCTTATTGTTGCAGATTTTGTGACAAAAGTTTTCCGAGATCGTGTGATATAGAAGTTCATGAACGTTCTCATACTGGCGAGAGGCCGTTTTTGTGTGCAATTTGTGGATGTGCTTTTATCCAAGCCCCTCATTTAAGAACCCACACAAAGGTAGTCCATGGTactgaaaaatcatttaaatgtaTGTTGTGCGATCAAAAGTTCGCATTAAAGGATTATCTCACCACACACATGAACTGGCACATATATGGAACGACTTCCAAAAATTTAACTACATTCTGTCAAATATGTAATAAATCCGTTATAAATAGTAAAGCTCATAGCAGTCGCCATCTCGAGGAAGAACCAAAACTATGTGAAATTTGTAACAAAGTTGTTCACTATCCAACTATTCACATGATCGAACAACACTctgaagaaaaatatatttgtcaTATTTGCAAGAAgtcttttgcaaaaaaatatcagtTAAAATGCCACACAAGAGTACATAAagaaaaagtaacaaataatCTTCCATGTGATGTGTGTGGGAAATCCTTTAGATTAAAACAATTTCTTGAAATTCACCGAAGAATTCATACAGGAGAGAGGCCTTATAAATGTGAGGAGTGCGGAAGCCGCTTTGTTCAGCATGCACATTTAAATAGTCACATGAAAACTCATAGGGGAGAAAAGACATTTTGCTGTCCGTTTTGTGATAAAAGGTTCGCTTTAAATGGAAACCTGAAACAACATGTAATGACCCACACAGGCGAAAGACCTTTTATTTGTGAACATTGTTCTAAGGGTTTTATTAGTAGTTCTGGCTTAAGAAAGCACTTGGCTACGCATATTAAAACATAG
Protein Sequence: MVLDAACLKKLEIIDEEKNRISITLEQLKHKCRTCLLRDGLINVFTTQHKECLFSDLFDWFSLTKMSRYDGLPQKICGVCAKFIMDLHTFKQQIQKSLITFQFALGKHENLSIFQVNDLKVIQDNDKTTDIKTETLNDSDTGEVQDNNEDMGFSNNLNDETIDSDCGYSSNTKEVNSKNGDCKIKRNTNFNDENSENESTISACEDTEEQINEKLIEELDDTEIEEDSTNIILDHSYVKPKSLVELKSSANDADILGKKYKCEVCKSIFNERLKFLNHKKSEMEERRLMKCPICQKSVQRFKMEEHMHLHLQTNNDDSAVPSKITDYTCSFCNVKFSTRKQYLTHRRQEQNKIKTQNNKRTAKVPCPLCSKLINKYKMNFHLSTHSTEKPYMCDICGKKLRSNNSLKIHKYSHTEELPEVLCEVCGKVFKCLNKLNDHKKKIHHVKSYCCRFCDKSFPRSCDIEVHERSHTGERPFLCAICGCAFIQAPHLRTHTKVVHGTEKSFKCMLCDQKFALKDYLTTHMNWHIYGTTSKNLTTFCQICNKSVINSKAHSSRHLEEEPKLCEICNKVVHYPTIHMIEQHSEEKYICHICKKSFAKKYQLKCHTRVHKEKVTNNLPCDVCGKSFRLKQFLEIHRRIHTGERPYKCEECGSRFVQHAHLNSHMKTHRGEKTFCCPFCDKRFALNGNLKQHVMTHTGERPFICEHCSKGFISSSGLRKHLATHIKT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -