Basic Information

Gene Symbol
gtf3a
Assembly
GCA_028453745.1
Location
CM052087.1:10136351-10140674[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 7.3e-05 0.01 17.0 0.1 2 23 746 767 745 767 0.97
2 17 7.4 1e+03 1.2 0.6 1 19 773 791 773 792 0.91
3 17 0.83 1.2e+02 4.2 1.5 3 23 801 821 800 821 0.97
4 17 0.00024 0.034 15.3 1.2 3 23 830 851 829 851 0.98
5 17 0.0036 0.5 11.7 2.1 1 23 858 881 858 881 0.95
6 17 8.7e-05 0.012 16.7 0.7 1 23 887 910 887 910 0.94
7 17 1.2 1.7e+02 3.7 2.5 2 23 918 938 918 938 0.94
8 17 1.3e-07 1.8e-05 25.6 2.1 2 23 944 965 943 965 0.97
9 17 2.1e-06 0.00029 21.8 0.2 1 23 971 993 971 993 0.99
10 17 0.00052 0.072 14.3 2.4 2 23 1005 1027 1004 1027 0.95
11 17 0.0073 1 10.7 2.5 1 23 1033 1056 1033 1056 0.96
12 17 0.011 1.5 10.1 3.0 2 23 1078 1100 1077 1100 0.95
13 17 0.001 0.14 13.4 1.4 2 23 1107 1129 1106 1129 0.96
14 17 3.5e-05 0.0049 18.0 1.0 2 23 1137 1158 1136 1158 0.96
15 17 0.0016 0.23 12.7 2.1 1 23 1164 1187 1164 1187 0.96
16 17 0.3 42 5.6 3.2 2 23 1194 1215 1193 1215 0.96
17 17 0.0088 1.2 10.4 2.6 1 23 1221 1243 1221 1243 0.98

Sequence Information

Coding Sequence
ATGCAGCACATTGAAGTGAATAACAGAGATCATAACTATAGTGAAGTAAAAGTAGATAATCTTCAGTATGCTGATGACAGTACTTCTAATGTATCTGTGAACGACATAAAAGCAGTTTATAAATCAAATAAACCAGCGTTAATACCAAACAAGGAAACATTTGGTCAAGTTAAAGATATAAATGAATTAAAAAAAATAACACCTCGTGTAAAGCTATTGGCTCACGATGCTAGCAGTCTAACGGAGCTGACAAAAATTTCTTTCCACAATAAAATATCTACACAAAAAAAGGTATGCATATCGGAACAAACAAAACAAGAATTAAAGAAATATTGCAGGACTTGTGCTGGTTTGAAGCTTCCATTGGTGGATATTTTTAGCGAAAAAGGCATTCAAATGAGGTTGAGTCAACAACTTAAACACTTAGAAGAAATAAATTCATATGATAGTTTATCAACTCAAATGTGTATGGATTGTATTTGTGATTTAAAAATGAGTTATAAGTTTTTTATGCAAATTAAGAAAGCAGAAGTAAAGTTAAAGTCTATTCACAATTCTCTGGCAGATACAGCAGCAAAGAATGCAGAAATGAACAAAATGCAATCGATAGCAGATATTGAAAAATCAGAAATAAAGATAGAAAGTTGCAAAGAATGCAGTATAATTGATCCATATTCTAGTAGGAAACTTAATGATCAAATGACTGCACAAAATGTAATAGCTTCTTCAATAAAAGAAGAACAAAAATGTTCAACGAAAATTGAAACCATAGATATTACTAAAGAATCAGATAACAATGTTACAGTAAAAATTTTCGAAGATATGACAATTCAACACAATAGTGATGATAACGAGTCTATAGAAGAGTTTGATCCAGACGATCCACCTTTTCAACCTGATAGTTCCGATGCTTTAGAATCTGATGATGAAATTAATTTTCAAACACCAGGTACCAAAAAGAAAAATATTCAGCAAAAGGATAGTATTCTAAAGAAGTGTTTACAACCAGTCTTTATTTGTGATAATAATTCTGTCTCAGATACTAAAACTACAGATTTTAATCAAACAACATATAAATACGATACATCGTCAAATGTATACATCAAACTAGAGAAGAGTACAGAAGGTAGTAATTGTTCTACTGAACCATATAGCATATCTAAATCTGAAACTGTATGTAACAGTGAAAGTACAAAAGAATCTACAAAACAGCCAAACATATTAAAAAGGAGACTTTTACTACAATCAAAGAAAGAACCCAGTGAAGAAACAGACGAAAATATTTGTCAATCTAATGTCTCTGACAAAGGTGGAACTTATAAAGACGTTAAAGTACAAAAATTGGATTTAAACAATCCTTTAAGCATTAATAGCAATCAGGAAGATGGGATCATGTATGTTACTGTTAAAGGTTCCAAACCAAATGAACTGTTATTAGTCAAAGTTAAAAAAATGGATAAACCATTAGAGAAAAAAGAAGAGAAACCAGTAGGAAAGAAAAATTTTGATATTAAACCTATGGAAAAAATCTTAAAGCGGTATGAAACATTGGCCACAAAAGAAAAAGATCTGTTTCCAGAGCGGACAAAAAAATCTGAAATGAGAGAACAGATCATTGAGGAACAAATCGAAGAGTATAAGAAAAAACGAGAAAAAGTATTAGGAGGTCATGCTAATATTTCACTTCCTTTGAAACTTGAAGAAACTCAGACTCGTTTTGTAAAACGTAATGAAACTCAGGAGAATAAGAGGTTCTCTGCATGCGGAGACAGTGATTCAATTGGCAATGTACAGTTTGATAAAGATAATAATGATAGTAATGCAAGTACTATAAAAAACGACAATGATAGTTCAGGGAATGCAGAATCTATAAAAGATAAATCCACTAATGAAAAAACTTATGTAAATACTGAAGAATATTTGTCAAGTTTGGCTAAACTTAAGCTGAAGTGGGAGGAAGCAAAGAAAAAGAAAGAATTTCTTCAAAAAGAACTTGACGAATCTTATACAGAAGGAAATATTGAGAAATTAACAAGAATTCTAGGAGAGAAAGAGAAAAATTTACAAGACTTTCAAGACTATTTGAAACAACGTAAAATTGTTGTTACAAGACTAAAAGATGAAGACATAATATCTCTGTACGAAGATAGAAATAATGCTGTGTTAAAAAACAACCTACCCGATTTAATAGATGAAAGTCAGCCTGCAGATTATATTCCAGAAGAGCACTATCTAGAATGTGATTATTGTCCAGAGACTTTTGCTTCTAAAGATGTACTCGAGGAACATTTAAAAATGCATGATTATAAAATTATGCATTACTGTGAAGATTGTATGGAGGAGTTTCCAACTAACAAAGCAAAAAGGAATCACAATGTAATTTGTATAAAAAAAAAGTTATGTAAATATTGTGACATGATGTTAGACTCGAAAGGGAAAAAGCGGCAACATGAACAGAAACATTGTGATAGTATGTATGGACAACTATGCGATGTGTGTGGTGAAAAATTTAAACATCAAGGAACATTGGATCAACATGTAAAGACACAGCATATGAGTTGGGAAAAGATATTTCAATGTCCAAAATGTCCTAAAAAGTTCGCTTTTAAACAAAAACTTAGCTTTCATTTAAAATCTGTACACACAACATTAAGAGCTTATTTATGTGAAGATTGTGGAGCAGATTTTAAAAATCCTGCAAGTCTTAGACATCATAGAATACGCAAACATCAACCAGTAGGTAATAAACGTGAATGTCCAGTTTGCCACAAGTTAGTGCCATTTTATAGTCTCTCAAAGCACATGCACACACATAAGGCATATACTATTCAGTGTCCACACTGTGACAAAATGTTTAAAAATAGCTCTACTTTGAAACAACATGTACGAATTCATGAAGATCAGCGTCAATATAGATGCGATACTTGCGGTGTTGGTTTTAACAGGCGCGACGGTTTAAGATTGCATATGAGAGTTCATGAGAAAACTGATAGCAGAGGACTAAAAGAATGCTCATGTCAAGTGTGCGGTGAAAAATTTCCAAATCACTCAACGCTTGTTATACATAGAAATCGAGTTCATAAAGATGGGAGACAATACACTTGTCACATATGTAATAGATCGATGATTTCAACTAGATCATTAGAATGGCATATGTCTCATATACACAACGAATCCCTTCCTGGTGTTGTAAAGGATGATTCAGATGGAACACCAGAAAAGAAGAGAGTATCGTGTTATCATTGTAACAAAACATTCAAAACAGAAATGATTTTAAGGACACATATTAAAAACACTCATATGGAGAAAGATCCTATGAAATGTTTAGACTGTGAATTAACGTTTACTTCTGAAGTGAGATTAAAACACCATATGATGGTGACTCATAACAGACTAGAAGGAACTCTACCATGTCCTCACTGTCCAAAGAGGTTTGTGAATCAGCTCAGGttaaagacacatatgatatcacattctgaagaaagaccatattcctgtgaaatttgtggaTTTAATTTGAAGACAAAAATACAGTTGATTAAACACCATCAGAATAGACATAGTGACGAAAGGCCTTTGCAATGTAGATACTGTCCATGGAGATGTAAACAAGTTAGCGCTCTTGTATGTCATGAAAGAACACATACGAATGAACGACCATACTCTTGTAGTGTGTGCAGACAAAGGTTCAAATACTTAGGTGATAAAAACAAGCATGAAAGACGACATGAAAGTTTAGGAGGATCAGGATTTAAACGAATAGTACCTGGTCGGAATATTAAACCGAAAATCGAAGATGAGTCTTCTTGTTCTGATCAAGAAACGGAAGGTGTAACTAACGCAGAATCTCAAATCGCTGAAGGAGAGTTTGAAGAACACACAGAATTTAAAGACGAACAGATAGTTAAGTTCGAAGAACAAGAGATAACAGAAGAATATGAGCAAGTGTATGAACAGGAGTATGAAGAAACATCCAGAGAAGCTTCAGATGCAGCAGAAGTAATAATGAATATGGAAGATACTACTGTTTATACGGAAGAGGTAACTGCAGATAATATTGAATCTGCGGAAATAATGACAGACGAAATAATGACGAATGAAATATTGCAATCTGGTGCTGTAGTTCATTTGCAACAGGAAGACGATTCAGGAAAAATACAAGTGATCCCAGTTATGTTGTCTTTACCTGATTTATCTGATGCGAATACTGAAGTTAATTTAGCTACAGCATCAATTATGTATAATAATTGA
Protein Sequence
MQHIEVNNRDHNYSEVKVDNLQYADDSTSNVSVNDIKAVYKSNKPALIPNKETFGQVKDINELKKITPRVKLLAHDASSLTELTKISFHNKISTQKKVCISEQTKQELKKYCRTCAGLKLPLVDIFSEKGIQMRLSQQLKHLEEINSYDSLSTQMCMDCICDLKMSYKFFMQIKKAEVKLKSIHNSLADTAAKNAEMNKMQSIADIEKSEIKIESCKECSIIDPYSSRKLNDQMTAQNVIASSIKEEQKCSTKIETIDITKESDNNVTVKIFEDMTIQHNSDDNESIEEFDPDDPPFQPDSSDALESDDEINFQTPGTKKKNIQQKDSILKKCLQPVFICDNNSVSDTKTTDFNQTTYKYDTSSNVYIKLEKSTEGSNCSTEPYSISKSETVCNSESTKESTKQPNILKRRLLLQSKKEPSEETDENICQSNVSDKGGTYKDVKVQKLDLNNPLSINSNQEDGIMYVTVKGSKPNELLLVKVKKMDKPLEKKEEKPVGKKNFDIKPMEKILKRYETLATKEKDLFPERTKKSEMREQIIEEQIEEYKKKREKVLGGHANISLPLKLEETQTRFVKRNETQENKRFSACGDSDSIGNVQFDKDNNDSNASTIKNDNDSSGNAESIKDKSTNEKTYVNTEEYLSSLAKLKLKWEEAKKKKEFLQKELDESYTEGNIEKLTRILGEKEKNLQDFQDYLKQRKIVVTRLKDEDIISLYEDRNNAVLKNNLPDLIDESQPADYIPEEHYLECDYCPETFASKDVLEEHLKMHDYKIMHYCEDCMEEFPTNKAKRNHNVICIKKKLCKYCDMMLDSKGKKRQHEQKHCDSMYGQLCDVCGEKFKHQGTLDQHVKTQHMSWEKIFQCPKCPKKFAFKQKLSFHLKSVHTTLRAYLCEDCGADFKNPASLRHHRIRKHQPVGNKRECPVCHKLVPFYSLSKHMHTHKAYTIQCPHCDKMFKNSSTLKQHVRIHEDQRQYRCDTCGVGFNRRDGLRLHMRVHEKTDSRGLKECSCQVCGEKFPNHSTLVIHRNRVHKDGRQYTCHICNRSMISTRSLEWHMSHIHNESLPGVVKDDSDGTPEKKRVSCYHCNKTFKTEMILRTHIKNTHMEKDPMKCLDCELTFTSEVRLKHHMMVTHNRLEGTLPCPHCPKRFVNQLRLKTHMISHSEERPYSCEICGFNLKTKIQLIKHHQNRHSDERPLQCRYCPWRCKQVSALVCHERTHTNERPYSCSVCRQRFKYLGDKNKHERRHESLGGSGFKRIVPGRNIKPKIEDESSCSDQETEGVTNAESQIAEGEFEEHTEFKDEQIVKFEEQEITEEYEQVYEQEYEETSREASDAAEVIMNMEDTTVYTEEVTADNIESAEIMTDEIMTNEILQSGAVVHLQQEDDSGKIQVIPVMLSLPDLSDANTEVNLATASIMYNN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00684931;
90% Identity
iTF_00184099;
80% Identity
-