Basic Information

Gene Symbol
-
Assembly
GCA_028453745.1
Location
CM052099.1:11746533-11747823[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.00094 0.13 13.5 0.4 1 23 129 151 129 151 0.98
2 10 7.5e-07 0.0001 23.2 1.0 1 23 157 179 157 179 0.99
3 10 1.3e-07 1.9e-05 25.6 0.4 1 23 185 207 185 207 0.98
4 10 0.0003 0.042 15.0 1.0 2 23 214 236 214 236 0.96
5 10 6.1e-06 0.00085 20.4 3.8 1 23 241 263 241 263 0.97
6 10 0.00085 0.12 13.6 3.0 1 23 272 294 272 294 0.96
7 10 2.5e-06 0.00035 21.6 2.2 1 23 300 322 300 322 0.97
8 10 4.7e-06 0.00065 20.7 0.1 2 23 329 350 328 350 0.96
9 10 1.1e-06 0.00015 22.7 3.5 1 23 356 378 356 378 0.98
10 10 3e-07 4.2e-05 24.5 0.9 1 23 384 406 384 406 0.98

Sequence Information

Coding Sequence
ATGGGCACTCGGTTCCAGAAGAATGAAGAGGACATCGGTAAAATTCGCCGCTTCGTTTCCTCGTGTATAATCAGTGTATACCAACCACATGTAAATCGACCCGACCTAATCTTAATAAAAAAAAAACAAACAGATTCTTCCCGCAAAACCGAAGTTGTCGTTGCATCTAGATCGATAGAATCTACGGAACCGGCGATAGGACGAACAAGTAGTTCAGCCATCTTGGAAAAGTTGGTCTTGACTACGATCAAGAACGAGAATATTCCCGCGAGAGGCGTCAAGCTTCCGTCGCTGAGCACGACGGAGGTCTTGGAGAAGCTCGACCGAGAAACCGAGGACGCCGAGAAGAATTCCTCGTCGCCTGATCAATCCTCGCAGACGTGCtaccagtgcgaagtatgcgcgaagcttttccggacgaagaacctgtacgagggtcatttgatctcgcacagcgacgctcgtccgttccaatgcgacatctgcgagaagacgttcaagaggacgaacaccttggctgtccatcgaagaatccacacgagggagcggaatttcgtctgcgacgtttgcggccacgcgttcgtgcaggcctcgcagctgaccattcatcagaggaggcacttcgacaagtacaccaggtactgcgaggtctgcaagaagggcttcttcacgaacgcggagctgcacggccacatgaacgtgaagcacggcgcgaaagagcacgtgtgtcgctactgcaacaaatcgtttccgaacaatcatacgctggtgaaacacctgatggtacacgacccgaacttcaagccggtgaagcaccagtgcgagttctgcggcaagacgttcgtctacaagaactcgttggtcttccacgtgaagtcgcacatgggcgagaaccggcacgagtgtcatctgtgcggcaagtcggtgtcctcgaagggatcccttcaggatcatctgaggctacacagcggcgagaaacagctgatctgcgacgtctgcgggaaggcgttcatcaagaggagcacactggtcgtgcacaagaggatccacaccggagagaagccgtacacctgcgacacctgcgggaaatcgttcacgcaacactccacgctggtcattcacaaacgttatcacaccgggcagagaccgtatcagtgcgcctactgcaataagtctttcgtctcgaggtcgtcgttgaacgcgcacaacaaggtgcacgcggtgaatcccgatcattcgGACTGA
Protein Sequence
MGTRFQKNEEDIGKIRRFVSSCIISVYQPHVNRPDLILIKKKQTDSSRKTEVVVASRSIESTEPAIGRTSSSAILEKLVLTTIKNENIPARGVKLPSLSTTEVLEKLDRETEDAEKNSSSPDQSSQTCYQCEVCAKLFRTKNLYEGHLISHSDARPFQCDICEKTFKRTNTLAVHRRIHTRERNFVCDVCGHAFVQASQLTIHQRRHFDKYTRYCEVCKKGFFTNAELHGHMNVKHGAKEHVCRYCNKSFPNNHTLVKHLMVHDPNFKPVKHQCEFCGKTFVYKNSLVFHVKSHMGENRHECHLCGKSVSSKGSLQDHLRLHSGEKQLICDVCGKAFIKRSTLVVHKRIHTGEKPYTCDTCGKSFTQHSTLVIHKRYHTGQRPYQCAYCNKSFVSRSSLNAHNKVHAVNPDHSD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00140738;
90% Identity
iTF_00862729;
80% Identity
-