Basic Information

Gene Symbol
znf521
Assembly
GCA_963971205.1
Location
OZ020295.1:9561041-9563876[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 0.38 26 6.1 0.5 1 23 189 212 189 212 0.95
2 18 0.014 0.93 10.7 0.5 2 23 218 239 217 239 0.97
3 18 0.00028 0.019 16.0 0.9 2 23 270 292 269 292 0.96
4 18 2.6 1.7e+02 3.5 2.6 2 23 355 377 354 377 0.94
5 18 0.0016 0.11 13.6 0.4 1 23 383 406 383 406 0.93
6 18 0.0004 0.027 15.5 0.2 1 20 410 429 410 431 0.94
7 18 0.0062 0.42 11.8 1.7 1 23 439 462 439 462 0.96
8 18 0.067 4.6 8.5 0.5 1 23 467 490 467 490 0.92
9 18 3.6e-05 0.0025 18.8 0.5 3 23 504 524 503 524 0.98
10 18 0.01 0.7 11.1 3.0 1 23 530 552 530 552 0.98
11 18 0.23 16 6.8 0.9 2 23 561 581 560 581 0.97
12 18 8.1e-05 0.0055 17.7 3.1 1 23 591 613 591 613 0.97
13 18 0.1 7 7.9 0.0 3 23 619 638 618 638 0.95
14 18 0.059 4 8.7 0.2 1 23 654 676 654 677 0.96
15 18 5.7e-05 0.0039 18.2 1.6 1 23 683 705 683 705 0.98
16 18 4.2e-05 0.0029 18.6 4.1 1 23 711 733 711 733 0.98
17 18 0.00051 0.035 15.2 0.3 1 23 739 762 739 762 0.94
18 18 0.011 0.75 11.0 0.2 2 23 768 790 767 790 0.95

Sequence Information

Coding Sequence
ATGGAATCAGAATCAGTTGTAATCTCGGATCCTGCAGAAGTCACGATAACTTTCAAGGAATATGATGATTTTGATTTCATTCGGGATAATCTGAAGAACTTGTTATATTCACCTCAGTTCTGTGGTATCTGTCTGAAGGCCACGGACTTGTGCGGAGGGGAGGCAGAATTCGAAGTTGTCACATGTTGGAAGACAGACGTTAAGGCTTTGAAGGATATTGTTGAATACATTTTTAATGAGCAGGCTCAAGAAATCGTAGCAAGTGCCTATATGTGCAGTTCATGTATTGACAAAGTGTTGGAGTCGTATATCTTCATATACAATAGCAGAGAGTCAGCTAAAATAATTAACAAGTGCATAAATGAATTAAACTACAAAGCAGATACTGCTGCCGAGCAGTTATTTGAAAATGACAACTATGAAAATTCAGAAGTTGTAATGATATTAGAAAATAATGATACAATTTATCCGCAACAAACTCGTCAAGTACAGGCAGTTAAAATTAATACAGTTACtgtgaaaaagaaaaagcaAAAAGCAAAAACCTATAAAAAGCATGCTGGTTATCGCTGCGTTGAGTGCAACATCATTGTCCAAACATTCAAAGAATGGAAACGGCATGAGAGGGACTTTCATGAGAAACCACAAATCCAATGTCAAATTTGTTTAAAGATATTGAGCAGTGATCAAAGTTTGAAAATCCACTACAAAACACATGCCATGATGAAATGCAAGATTTGCCAATTGCTCATTCCTGATGGGGACATGAATGAGCATTTCAGATTGAACCATGACGATGACAAACAGACATGCTATATTTGTAACCTGTCATTTTACACTAACAGTGATATGAATACGCATCTAAAAATTAGTCATCCTGAAGAGGATGACCCAGAGAATAAAAAATCACAATGCTTAATGTGTTTAAAACATTTTGAAGGAGAGGAGTTGAATGAACATAAATGCAAGTTCCGCTGTAGCGAATGTTCCGAAATACCTTGCATTCACTACAAGTATTTGGTATCTTACAGAGAGCAATTTAGGGCAAGATCACCTAAAATAAAATGCGTAGATTGTGACTACTTTTGTCACAAAAAGGACTTTTTAGTGGGCCATGCTAATCGAGAACATTTGGACCATATTCCTTTTGCTTGTGACATGTGTGGACAACGATTTTACTCGAAAGTAGGCCTACGGGGTCATATTTATCAGTTCCACACAGAAAGCTATGTTTGTAATTATTGTGATCAAGAATTCAAGGGTAGTGGAAGTCTTCAAACACATAAAATCTCTTGTGCAACTATCGAAAGGGAATTCAAATGTCCTGAATGCACAGCATCTTTTGATAGCGATAAGTTCCTTACTAATCATTTTCAAAGGAGACATATTCAGGAAACTTACCCCTGCAACTTGTGCACTAAAACATTTTTAACCGATGGAAAGCTTAAAGAGCACACTGTGAAAGTACATAGTGGGCTACAGAACAGAAATAGGAGGTCATTCCCTGACTGCGTTATTTGTGAGCAAAAGTTCGACACGAGGGCCGATTTGAGACGCCACATAAAAACGCACGGTCCGAACGCAAAATTCCCTTGCCGAACATGTAATATAGAGTTTGATTCGTTGAAAAAACTGCACGTCCATCGAAGGAAGCATGTGAAATCCTATTGCGAACGTGTGAAATGCCCGGTCTGTAATATGGAGCTGCAGTCTGTATGCTTGTCTCAACATATGTTGCGCCATGCTGTAGAGTCGGGGGAAGCTCCAGCATACGATTGCGATATCTGTGGAAAATCATGCTCTTCGAAGGTTTATTTAAAATACCACAAACAAAGTCATATGGAGCCAGCCCCTTGTCCAATATGTGACAAACTTATCAAACCAGCTGGACTTCAAAAGCATATCAAATATCATGAGTATAAACATAATCCTGTGATGAGAGAGAAGATGAAACGGAGATACAAGTGTAATCTTTGCGAGTACATAGCTTCGGACCCTAGCATTTTAGAGGCGCACGCAAATCGACACCATCTTAAAGTCAAACCATATGTTTGCTCGGTTTGTGACAAAGACTTCTGCGGAAAACTACAGTTGCAAAGACATTTAGATACACACTATTCTTCAAAGACCTTCACTTGTGAGATTTGCCAGAAAAAGTTTTCCAACAAGATTTGTTTACGAATGCACTTGAGGTTGCATACAGGCGAGAGACCATACTACTGCGAGATTTGCGGTGATAGTTTTATATCAGCAAGTGCTTTGAAGACACATAAAGTCAAGCGACATACTGAGAAGTCCATACCGTGCCCATTATGTGATAAGATGTTTTACATTGCCGTCGAAATGAGGCAGCATTTCAAGAAGTATCACTGGCCGCATAAGGATCGAAAGTTTGACCACAGAGAAGTGGAGGGTTTGAGCAGAGACTTTTATCATCTGTTCGAAGATGGTCGACGGCCGAGGTTGGACGATGATACCAACATTGTCGAAGAAGAAAAAACTTGCAATGTTATCATTGAAGAAGttaatgaataa
Protein Sequence
MESESVVISDPAEVTITFKEYDDFDFIRDNLKNLLYSPQFCGICLKATDLCGGEAEFEVVTCWKTDVKALKDIVEYIFNEQAQEIVASAYMCSSCIDKVLESYIFIYNSRESAKIINKCINELNYKADTAAEQLFENDNYENSEVVMILENNDTIYPQQTRQVQAVKINTVTVKKKKQKAKTYKKHAGYRCVECNIIVQTFKEWKRHERDFHEKPQIQCQICLKILSSDQSLKIHYKTHAMMKCKICQLLIPDGDMNEHFRLNHDDDKQTCYICNLSFYTNSDMNTHLKISHPEEDDPENKKSQCLMCLKHFEGEELNEHKCKFRCSECSEIPCIHYKYLVSYREQFRARSPKIKCVDCDYFCHKKDFLVGHANREHLDHIPFACDMCGQRFYSKVGLRGHIYQFHTESYVCNYCDQEFKGSGSLQTHKISCATIEREFKCPECTASFDSDKFLTNHFQRRHIQETYPCNLCTKTFLTDGKLKEHTVKVHSGLQNRNRRSFPDCVICEQKFDTRADLRRHIKTHGPNAKFPCRTCNIEFDSLKKLHVHRRKHVKSYCERVKCPVCNMELQSVCLSQHMLRHAVESGEAPAYDCDICGKSCSSKVYLKYHKQSHMEPAPCPICDKLIKPAGLQKHIKYHEYKHNPVMREKMKRRYKCNLCEYIASDPSILEAHANRHHLKVKPYVCSVCDKDFCGKLQLQRHLDTHYSSKTFTCEICQKKFSNKICLRMHLRLHTGERPYYCEICGDSFISASALKTHKVKRHTEKSIPCPLCDKMFYIAVEMRQHFKKYHWPHKDRKFDHREVEGLSRDFYHLFEDGRRPRLDDDTNIVEEEKTCNVIIEEVNE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
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90% Identity
-
80% Identity
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