Basic Information

Insect: Aethes cnicana
Gene Symbol: ETV1
Assembly: GCA_963971205.1
Location: OZ020299.1:2318167-2326588[-]

Transcription Factor Domain

TF Family: ETS
Domain: Ets domain
PFAM: PF00178
TF Group: Helix-turn-helix
Description: Transcription factors are protein molecules that bind to specific DNA sequences in the genome, resulting in the induction or inhibition of gene transcription [3]. The ets oncogene is such a factor, possessing a region of 85-90 amino acids known as the ETS (erythroblast transformation specific) domain [3, 5, 4]. This domain is rich in positively-charged and aromatic residues, and binds to purine-rich segments of DNA. The ETS domain has been identified in other transcription factors such as PU.1, human erg, human elf-1, human elk-1, GA binding protein, and a number of others [3, 5, 2]. It is generally localized at the C terminus of the protein, with the exception of ELF-1, ELK-1, ELK-3, ELK-4 and ERF where it is found at the N terminus. NMR-analysis of the structure of the Ets domains revealed that it contains three α-helices (1-3) and four-stranded β-sheets (1-4) arranged in the order α1-β1-β2-α2-α3-β3-β4 forming a winged helix-turn-helix (wHTH) topology [1]. The third α-helix is responsive to contact to the major groove of the DNA. Different members of the Ets family proteins display distinct DNA binding specificities. The Ets domains and the flanking amino acid sequences of the proteins influence the binding affinity, and the alteration of a single amino acid in the Ets domain can change its DNA binding specificities.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 5.7e-06 0.02 15.8 0.0 1 36 45 77 45 81 0.92

2 8 1.4e-05 0.049 14.6 0.0 2 36 89 120 88 124 0.91

3 8 1.4e-05 0.049 14.6 0.0 2 36 132 163 131 167 0.91

4 8 1.4e-05 0.049 14.6 0.0 2 36 175 206 174 210 0.91

5 8 1.4e-05 0.049 14.6 0.0 2 36 218 249 217 253 0.91

6 8 1.4e-05 0.049 14.6 0.0 2 36 261 292 260 296 0.91

7 8 1.4e-05 0.049 14.6 0.0 2 36 304 335 303 339 0.91

8 8 2.1e-27 7.4e-24 84.5 0.0 2 81 347 432 346 432 0.92

#	of	c-Evalue	i-Evalue	score	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	5.7e-06	0.02	15.8	1	36	45	77	45	81	0.92
2	8	1.4e-05	0.049	14.6	2	36	89	120	88	124	0.91
3	8	1.4e-05	0.049	14.6	2	36	132	163	131	167	0.91
4	8	1.4e-05	0.049	14.6	2	36	175	206	174	210	0.91
5	8	1.4e-05	0.049	14.6	2	36	218	249	217	253	0.91
6	8	1.4e-05	0.049	14.6	2	36	261	292	260	296	0.91
7	8	1.4e-05	0.049	14.6	2	36	304	335	303	339	0.91
8	8	2.1e-27	7.4e-24	84.5	2	81	347	432	346	432	0.92

Sequence Information

Coding Sequence: ATGGCGCAGCAGTTCCCGCTGCCATGGGGCGGGGGCGCCGGCGCGGCGTGTGGGGGCCGCGCGGAGGCCTCGTCGCCGCACCAGCTCGTCTCCACCACAGGcagcgcgtcgggcgggcggcgcggcgcgcTGCAACTGTGGCAGTTCCTAGTGGCGCTCCTGGCCGAGGGCGCGCGCTGCGTGGGCTGGACGGGCCGCGGGCTCGAGTTCAAGCTGCACGAGCCGGAGGAGGCGAGTACCTCCCGGGCCTGTACTACGTTACTACTGTGGCAGTTCCTAGTGGCGCTCCTGGCCGAGGGCGCGCGCTGCGTGGGCTGGACGGGCCGCGGGCTCGAGTTCAAGCTGCACGAGCCGGAGGAGGCGAGTACCTCCCGGGCCTGTACTACGTTACTACTGTGGCAGTTCCTAGTGGCGCTCCTGGCCGAGGGCGCGCGCTGCGTGGGCTGGACGGGCCGCGGGCTCGAGTTCAAGCTGCACGAGCCGGAGGAGGCGAGTACCTCCCGGGCCTGTACTACGTTACTACTGTGGCAGTTCCTAGTGGCGCTCCTGGCCGAGGGCGCGCGCTGCGTGGGCTGGACGGGCCGCGGGCTCGAGTTCAAGCTGCACGAGCCGGAGGAGGCGAGTACCTCCCGGGCCTGTACTACGTTACTACTGTGGCAGTTCCTAGTGGCGCTCCTGGCCGAGGGCGCGCGCTGCGTGGGCTGGACGGGCCGCGGGCTCGAGTTCAAGCTGCACGAGCCGGAGGAGGCGAGTACCTCCCGGGCCTGTACTACGTTACTACTGTGGCAGTTCCTAGTGGCGCTCCTGGCCGAGGGCGCGCGCTGCGTGGGCTGGACGGGCCGCGGGCTCGAGTTCAAGCTGCACGAGCCGGAGGAGGCGAGTACCTCCCGGGCCTGTACTACGTTACTACTGTGGCAGTTCCTAGTGGCGCTCCTGGCCGAGGGCGCGCGCTGCGTGGGCTGGACGGGCCGCGGGCTCGAGTTCAAGCTGCACGAGCCGGAGGAGGCGAGTACCTCCCGGGCCTGTACTACGTTACTACTGTGGCAGTTCCTAGTGGCGCTCCTGGCCGAGGGCGCGCGCTGCGTGGGCTGGACGGGCCGCGGGCTCGAGTTCAAGCTGCACGAGCCGGAGGAGgcgagctatagtccccacgcaggcccaGTGGCGCGGCGCTGGGGCGCGCAGAAGAACCGCCCCGCCATGAACTACGACAAGCTGTCGCGCTCGCTGCGGTACTACTACGAGAAGGGCATCATGCAGAAGGTGGCGGGCGAGCGCTACGTGTACAAGTTCGTGTGCGACCCGGAGGCCCTGTTCAGTATGGCGGCGCCGCGGCCgcgctcgccgccgccgccgcccgcgcccgGCACATACGACGTGCTGTCGCAGTTGTACGGCGTGTACCCGCAGtggggcggcgcgggcgcacccGACTATCGCCGCTACCCGCCGTGCCCGCCCTGCCCGCACGAGCCCTGCGCCTACGACGCCTAA
Protein Sequence: MAQQFPLPWGGGAGAACGGRAEASSPHQLVSTTGSASGGRRGALQLWQFLVALLAEGARCVGWTGRGLEFKLHEPEEASTSRACTTLLLWQFLVALLAEGARCVGWTGRGLEFKLHEPEEASTSRACTTLLLWQFLVALLAEGARCVGWTGRGLEFKLHEPEEASTSRACTTLLLWQFLVALLAEGARCVGWTGRGLEFKLHEPEEASTSRACTTLLLWQFLVALLAEGARCVGWTGRGLEFKLHEPEEASTSRACTTLLLWQFLVALLAEGARCVGWTGRGLEFKLHEPEEASTSRACTTLLLWQFLVALLAEGARCVGWTGRGLEFKLHEPEEASTSRACTTLLLWQFLVALLAEGARCVGWTGRGLEFKLHEPEEASYSPHAGPVARRWGAQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAAPRPRSPPPPPAPGTYDVLSQLYGVYPQWGGAGAPDYRRYPPCPPCPHEPCAYDA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -