Basic Information

Gene Symbol
-
Assembly
GCA_005406045.1
Location
BHDV01069799.1:128373-138555[-]

Transcription Factor Domain

TF Family
HSF
Domain
HSF_DNA-bind domain
PFAM
PF00447
TF Group
Helix-turn-helix
Description
Heat shock factor (HSF) is a transcriptional activator of heat shock genes [1, 4]: it binds specifically to heat shock promoter elements, which are palindromic sequences rich with repetitive purine and pyrimidine motifs [1]. Under normal conditions, HSF is a homo-trimeric cytoplasmic protein, but heat shock activation results in relocalisation to the nucleus [2]. Each HSF monomer contains one C-terminal and three N-terminal leucine zipper repeats [3]. Point mutations in these regions result in disruption of cellular localisation, rendering the protein constitutively nuclear [2]. Two sequences flanking the N-terminal zippers fit the consensus of a bi- partite nuclear localisation signal (NLS). Interaction between the N- and C-terminal zippers may result in a structure that masks the NLS sequences: following activation of HSF, these may then be unmasked, resulting in relocalisation of the protein to the nucleus [3]. The DNA-binding component of HSF lies to the N terminus of the first NLS region, and is referred to as the HSF domain.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 0.0021 14 6.4 0.0 34 90 724 797 713 804 0.66
2 4 0.0018 12 6.6 0.0 34 88 1047 1118 1037 1127 0.65
3 4 0.0011 7.8 7.3 0.1 35 90 1371 1443 1361 1450 0.67
4 4 3 2.1e+04 -3.8 0.0 55 68 1517 1530 1516 1554 0.71

Sequence Information

Coding Sequence
ATGGATCAAAGAAAAGACGATGAAATATTACCAAAGCAAGAGAATGTAACACTCTTCTATGAACTGCTGAACTACTGCAGAAGACTACCAGCTTTATGGAATCCTACGCACGAGGGTTTCTTCGACAAGGATTTGGGGAAGAAATCCTATTTACTGCTActgtataagtacataaatatctCTAGTAACGAGTCAGGACAAGACTTGGACGATGTGATCATCGGTTTGAAATGGTACCTCCAAAATGAATACTTTAGTCGCTTTGTTAAGAGTAAACAGGGGGCAGTTTTTCAGGACAACCGTGAAATATGGCGCGAGATAGATGTGACAAGCGAATTCATGAAACTCACTTTGAATGTTGGTCACAAGGAAATGGATTACCAGTACGCGATATGCAAACCGATGTTGATGCCTTATTCAATGGATTATACACCGCCACCAGTCGGGAAGGTAGCTCagtatttaggtattttaacCGACTCGATTCTTCCGCTACAATGGCCGAACATAGATCCTCGGTCAGGGACAAATATGATGACAGGGGAACATCAGCAAGCGATGAATGCTGAACCGCCTTTCCTGAAACAATCTCCAGAAATGGCGAAACCAACCATTCCTTCTCGGCTAGACGGAACTGCTATCAGAGAATATTTGCCTACCGGACCACGTACAGAAGATTCTTCATCTCTAGATAAGTCCACAGAAGAACCTTTACCGGATACTTACTTACCAAAGTTAACGCCCGTGCCAGAAGAAAATGTGTATTCAGAATACCAACAACCGTCGTACGAAGGAATACACGCAGGAGATTTGTCGTCGAGAAATGAGACCGAACCAATGGTACTGGTACCCAGGCCGGACGGTATTCCCACAGACAGCGAAAATGATCATCGTCAAACATTATCAGTACACTATGAAGCTCCCGATGAAGAACATTTAACGCAAAAGGCCGGTGACCGAAACATAACACCAGTATCAGATGCGAATGGTGCATATCCGCGATACCAACAACGGTTGTACGATGGAATCCGCTCAGAAGATCCTTCGAAGAGACTTCCTCTATACCATCAATTTTCAACGAGAGATCAATCAGCGCAACTGACCTCAGTACCCGTACCAGATCGAAATACTGCACACTCTCGATACCAACAATCTCCAACGAGAGATCAATCACCGCAACTGGCCACAGTACCAGAATCAGATCCAAGTGCCGCACACTCTCTATACCAACAATCTTCAACGAGAGATAAATTTGTGTTACTGATTACAGTACCCGTATCAGATCGAAACGTTGCACATTCTTGGTACCAACAATCTCCAACGAGAGATCAATTCGCGCAACTATCCCCTACACCAGAATCAGAACGTAGTGCTGCACACTCTCGACATCAAAAATCACCAACGAGAGATCAATCAGCGCAACTAGCCACAGTACCAGAATCAGATCCAAATGCCGCACACTCTCTATACAAACAATTTTCAACGAGAGATCAATCCGCGCAACTAACCACAGTACCCGAATCAGATCGAAACGTTGCACAGTTTTGGTACCAACAATCTCCAACGAGAGATCAATTCGCGCAACTATCCCCTACACCAGAATCAGAACGTAGTGCTGCACACTCTCCATACCAACAATCTCCAACGAGAGATCAACTAGCCATAGTACCAGAATCAGATCCAAATGCTGCACACTTTCGATACCAACAATCTTCAACGAGAGATCAATTTGTGCAAATGATTACAGTACCCGAATCAGATCTAAATGCCGCACACTCTCTATACCAACAACTTTCAACGAGAGATCAACCCGCACAACTAACCACAGTACCCGTATCAGGTCGAAATGTTGTACACTCTCGATACCAACAATCTTCAACGAGAGATCAATCAGCGCAACTAACCATAGTATCAGAATCAGAACGAAATGCTGCACACCATCGATATCAACCAAGATTGGAGTCCATGCAGTCAACCATACCATCCAGGTCAGACGGTATTCTTACAGGCAGCGAATACTATCATAGCCAAACATATACAGGACATTCATCGCGACATGAGCCCGCGCGTCCAAACATGGTTCCAGTATCGAAAGGGAATGCTGCTTATCCAGAATACCAACGATTGTCGGACTTTGGAATTCACATAGAAGACCCTTCAACCAGAGAGCAATTCGTGCAATCAAACGTAATATCCATTTCAAACGAAAATGCTGCATGTTCAGGATACCAACAATTGTCACACTATGGATTTCACACAGAAGAAACTACAACGAGAAATCAATTCGCGGCATTAAGTATAACACCTAATTCAAAAGGAAATGCTGCAAGCTCTCCTGAGCATTGGATTCCTTGTACAAAATGGTCGCACTATGGATTTCGCACAGAAGAATCTTCAACGAGAAATCAATCCGCGGCATTAAgtatagtacctatttcaaaaggAAAAGCTGCAAGCTCTCCTGTGCATTGGTTTCCTTATAAAAAATTGCCGCACTATGAATTTCGCACAGAAGAATCTTCAACGAGAGATCAATTCGCGCAACTATCCCCTATACCAGAATCAGAACGAAGTGCTGCACACTCTCCATATCAACAATCTCCAACGAGAGATCAATCAGCGCAACTAGCCACAGTACCAGAATCAGATCCAAATGCTGCACACTCTCGATACCAACAATCTTCAACGAGAGATCAATTTGTGCAAATGATTACAGTACCCGAATCAGATCCAAATGCCGCACACTCTCTATACCAACAATTTTCAACGAGAGATCAACCCGCACAGCTAACCACAGTACCCGTATCAGGTCGAAATGCTGCACACTCTCGATACCAACAATCTTCAACGAAAGATCAATCAGCGCAACTAACCATAGTATCAGAATCAGATCGAAATGCTGCACACCATCGATATCAACCAAGATTGGAGTCCATGCAGTCAACCATACCATCCAGGTCAGACGGTATTCTTACAGGCAGCGAATACTATCATAGCCAAACATATACAGGACATTCATCGCGACATGAGCCCGCGCGTCCAAACATGGTTCCAGTATCGAAAGGGAATGCTGCTTATCCAGAATACCAACGATTGTCGGACTTTGGAATTCGCATAGAAGACCCTTCAACTAGAGAGCAATTCGTGCAATCAGACGTAATATccatttcaaaagaaaatgctGCATGTTCAGGATACCAACAATTGTCACACTATGGATTTCACGCAGAAGAAACTTCAACGAGAAATCAATTCGCGGCATTAAGTATAACACCTAATTCAAAAGGAAATTCTGCAAGCTCTCCTGAGCATTGGATTCCTTGTACAAAATGGTCGCACTATGGATTTCGCACAGCAGAATCTTCAACGAGAAATCAATCCGCGGCATTAAGTATAATACCTATTTCAAAAGGAAATGCTGCAAGCTCTCCTGAGCATTGGTATCCTTATAAAACATTGTCGCACTATGAATTTCGCACAGAAGAATCTTTAACTAGAGATCAATTCGCGCAACTATTCCCTATACCAGAATCAGAACGAAGTGCTGCACACTCTCCATATCAACAATCTCCAACGAGAGATCAATCAGCGCAACTAGCCACAGTACCAGAATCAGATCCAAATGCCGCACACTCTCGATACCAACAATCTTCAACGAGAGATcaatttatgcaactgattacAGTACCCGAACCAGATCCAAATGCCGCACACTCTCTATACCAACAATTTTCAACGAGAGATCAATCCGCACAACTAACCACAGTACCCGTATCAGCTCGAAATGCTGCACACTCTCGATACCAACAATCTTCAACGAGAGATCAATCACCGCAACTAACCATAGTATCAGAATCAGAACGAAATTCTGCACACCATCGATATCTACCAAGATTTGAGTCCATGCAGTCAACTATACCATCCAGGTCAGACGGTATTCATAAAGGCAGCGAATACTATCATAGCCAAACATATACAGGACATTCATCGCGACATGAGGCCGAGCGTCCATACATGGTTCCAGTATCGAAAGGGAATGCTGCTTATCCAGAATACCAACGATTGTCGGACTTTGGAATTCGCATAGAAGACCCTTCAACCAGAGAGCAATTCGTGCAATCAGACGTAATATccatttcaaaagaaaatgctGCATGTTCAGGATACCAACAATTGTCACACTATGGATTTCACACAGAAGAAACTTCAACGAGAAATCAATTCGCGGCATTAAGTATAACACCAAATTCAAAAGGAAATTCTGCAAGCTCTCCTGAGCATTGGATTCCTTGTACAAAATGGTCGCACTATGGATTTCGCACAGAAGAATCTTCAACGAGAAATCAATCCGCGGCATTAAGTATAATACCTATTTCAAAAGGAAATGCTGCAAGGTCTCCTGAGCATTGGTATCCTTGTAAAAAATTGTCGCACTATCAATTTCGCACAGAAGAATCTTCAACAAGAAATCAGTCCGCGGGATTAAGCATAATACCCATTTCAAAAGGAAATGCTGCAAGCTCTCCTGAGCATTGGATTCCTTGTACAAAATTGTCGCACTATGGATTTCGCACAGAAGAATCATCAATGAGAAATCAGTCCGCGGGATTAAGCATAATACccatttcaaaagaaaatgttgCATGCTCAAGATACCAACAATCGTCGCACTATGGAATTCGTTCAGAAGAACCTTCCACTAGAGAACAATCCGCGCAATCAACTATAGTACCTGTATCAAAAGAAAATACCGTATATTTTGAAAACCCCGTTCACATAGAGCATACTGGACCCAATGTACCTTTACGTACAGAAGAattgtttttagaaaaacaGTGTCGGCCTCCTACAATAGTAAATCTGTCTTTATCACCGAAAAAGCGgatattagaaaaatataaaCCGCAAAATCGACTGGAACTAGGGACAGTGAGAGAAAAATCAAGTTTAGGCAAGAGGTCTCCTAAAAAAATCTCGAAGTTAGCACCAAATACTGCTGCTTTGACTACCGGCCAATATACAAAACCGATGAATACGCTTCTTCCATTAAATGCAATCGAAGAATCTTATTCAAGCGACATCTCCAAAACATCAAAATACAACCAATCTATTGATACCGAAGATATTGAAACAGATAGTAACTTGTTAAACGTCTCCGCGGAAAACTTCGCGGCTCCTCAAACAAGCAAGTCTAACACGCCTCTCACACATCTTTCtgggaagaaaaaaaataaaaaaaaatctacagcGGCATACGATTCGTCGTTTACTCCTAAAAAGACAAGGTCGAAGAAAAATCCGATACCAGCGGGGAATAAAACGCGAAAAGTCttgaaaaagctgaaaaaaagaaaatctgtaaaaaaagaTGTGAAGAATGAAATATTACGTCGAATACTTGTAAAGAAAAGCTCTCCGACATCAAAAAGTAGTTGCCTGAATCACCCGCAAAATATTCAGAAAGCTGATAATTTACCAAACCCCTCCGCGAATATCTTGGAGACTAAAATCAGCGAGTATGAAACCAACCTTTCCGCGAATATTTTGGAGAATGAAATCAGCGAGCATGAAACCAACCTCTCCGCGAATATCTTGGAGAATGAAATCAGCGAGCATGAAACCCGCCAGGCGGAACTTTCAATACAGAAAGAATTGGAAGATATGCACTGGTCACGCGAGAAATCACCTCCGCAGGGTCCTTGTGTGACAATTGTCAACGCAATACAAAATGACGAGAATGTCCCAGAATTGAATCCTATTAGCCAAACTGACTACCAATCCAAAGAAAATGAATCTGAATTACCAAGTTCAGCCAGTGAATAA
Protein Sequence
MDQRKDDEILPKQENVTLFYELLNYCRRLPALWNPTHEGFFDKDLGKKSYLLLLYKYINISSNESGQDLDDVIIGLKWYLQNEYFSRFVKSKQGAVFQDNREIWREIDVTSEFMKLTLNVGHKEMDYQYAICKPMLMPYSMDYTPPPVGKVAQYLGILTDSILPLQWPNIDPRSGTNMMTGEHQQAMNAEPPFLKQSPEMAKPTIPSRLDGTAIREYLPTGPRTEDSSSLDKSTEEPLPDTYLPKLTPVPEENVYSEYQQPSYEGIHAGDLSSRNETEPMVLVPRPDGIPTDSENDHRQTLSVHYEAPDEEHLTQKAGDRNITPVSDANGAYPRYQQRLYDGIRSEDPSKRLPLYHQFSTRDQSAQLTSVPVPDRNTAHSRYQQSPTRDQSPQLATVPESDPSAAHSLYQQSSTRDKFVLLITVPVSDRNVAHSWYQQSPTRDQFAQLSPTPESERSAAHSRHQKSPTRDQSAQLATVPESDPNAAHSLYKQFSTRDQSAQLTTVPESDRNVAQFWYQQSPTRDQFAQLSPTPESERSAAHSPYQQSPTRDQLAIVPESDPNAAHFRYQQSSTRDQFVQMITVPESDLNAAHSLYQQLSTRDQPAQLTTVPVSGRNVVHSRYQQSSTRDQSAQLTIVSESERNAAHHRYQPRLESMQSTIPSRSDGILTGSEYYHSQTYTGHSSRHEPARPNMVPVSKGNAAYPEYQRLSDFGIHIEDPSTREQFVQSNVISISNENAACSGYQQLSHYGFHTEETTTRNQFAALSITPNSKGNAASSPEHWIPCTKWSHYGFRTEESSTRNQSAALSIVPISKGKAASSPVHWFPYKKLPHYEFRTEESSTRDQFAQLSPIPESERSAAHSPYQQSPTRDQSAQLATVPESDPNAAHSRYQQSSTRDQFVQMITVPESDPNAAHSLYQQFSTRDQPAQLTTVPVSGRNAAHSRYQQSSTKDQSAQLTIVSESDRNAAHHRYQPRLESMQSTIPSRSDGILTGSEYYHSQTYTGHSSRHEPARPNMVPVSKGNAAYPEYQRLSDFGIRIEDPSTREQFVQSDVISISKENAACSGYQQLSHYGFHAEETSTRNQFAALSITPNSKGNSASSPEHWIPCTKWSHYGFRTAESSTRNQSAALSIIPISKGNAASSPEHWYPYKTLSHYEFRTEESLTRDQFAQLFPIPESERSAAHSPYQQSPTRDQSAQLATVPESDPNAAHSRYQQSSTRDQFMQLITVPEPDPNAAHSLYQQFSTRDQSAQLTTVPVSARNAAHSRYQQSSTRDQSPQLTIVSESERNSAHHRYLPRFESMQSTIPSRSDGIHKGSEYYHSQTYTGHSSRHEAERPYMVPVSKGNAAYPEYQRLSDFGIRIEDPSTREQFVQSDVISISKENAACSGYQQLSHYGFHTEETSTRNQFAALSITPNSKGNSASSPEHWIPCTKWSHYGFRTEESSTRNQSAALSIIPISKGNAARSPEHWYPCKKLSHYQFRTEESSTRNQSAGLSIIPISKGNAASSPEHWIPCTKLSHYGFRTEESSMRNQSAGLSIIPISKENVACSRYQQSSHYGIRSEEPSTREQSAQSTIVPVSKENTVYFENPVHIEHTGPNVPLRTEELFLEKQCRPPTIVNLSLSPKKRILEKYKPQNRLELGTVREKSSLGKRSPKKISKLAPNTAALTTGQYTKPMNTLLPLNAIEESYSSDISKTSKYNQSIDTEDIETDSNLLNVSAENFAAPQTSKSNTPLTHLSGKKKNKKKSTAAYDSSFTPKKTRSKKNPIPAGNKTRKVLKKLKKRKSVKKDVKNEILRRILVKKSSPTSKSSCLNHPQNIQKADNLPNPSANILETKISEYETNLSANILENEISEHETNLSANILENEISEHETRQAELSIQKELEDMHWSREKSPPQGPCVTIVNAIQNDENVPELNPISQTDYQSKENESELPSSASE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-