Basic Information

Gene Symbol
-
Assembly
GCA_951802165.1
Location
OX637703.1:644065-663291[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 24 0.039 5.2 8.9 0.4 2 23 106 128 105 128 0.94
2 24 0.028 3.7 9.4 1.5 1 23 134 157 134 157 0.96
3 24 0.0018 0.24 13.2 0.7 1 23 163 186 163 186 0.97
4 24 0.0014 0.19 13.5 3.4 1 23 192 215 192 215 0.98
5 24 0.00048 0.064 14.9 0.3 1 23 221 244 221 244 0.96
6 24 0.00062 0.082 14.6 4.2 1 23 251 274 251 274 0.96
7 24 0.0031 0.41 12.4 1.8 1 23 280 303 280 303 0.97
8 24 0.0033 0.44 12.3 0.2 1 23 309 332 309 332 0.96
9 24 0.0011 0.15 13.7 0.9 1 23 367 390 367 390 0.95
10 24 0.00016 0.022 16.4 0.4 1 23 411 434 411 434 0.98
11 24 0.013 1.7 10.5 0.1 1 23 440 463 440 463 0.92
12 24 0.0064 0.85 11.4 2.0 1 23 469 492 469 492 0.95
13 24 0.0056 0.74 11.6 0.7 1 23 498 521 498 521 0.96
14 24 7.8 1e+03 1.7 0.3 1 23 528 551 528 551 0.89
15 24 0.032 4.3 9.2 3.4 1 23 557 580 557 580 0.97
16 24 1.1 1.5e+02 4.4 1.1 1 17 586 602 586 605 0.90
17 24 0.00042 0.056 15.1 0.7 1 23 778 801 778 801 0.97
18 24 0.00056 0.075 14.7 0.3 1 23 807 830 807 830 0.96
19 24 0.0022 0.29 12.8 0.2 1 23 836 859 836 859 0.93
20 24 0.0072 0.96 11.2 0.3 1 23 865 888 865 888 0.97
21 24 0.048 6.4 8.7 0.3 1 23 894 917 894 917 0.98
22 24 0.012 1.5 10.6 0.6 1 23 923 946 923 946 0.96
23 24 8.1e-05 0.011 17.4 4.3 1 23 952 975 952 975 0.98
24 24 6.4e-05 0.0085 17.7 0.4 1 23 981 1004 981 1004 0.95

Sequence Information

Coding Sequence
atggACGAGTTCGAAACTATAAAAGATGAAATAGAGGATATAGATATATCTGAGGAGTTTATTGTAGGTAATGAAGTAATTAAAAGACAAGAGGTTGGGGAGAGTCTTGATTCTAACGTCAAATCTGATGTTGATGATTGTAAGGGCGACTTCGAAATAAAAAAGGATGAGATAGAAGATGTTGATATATCTGAGGAGATCGTTGGTAATGTAATATGTAAAAGTGaatatttcgatgaggatattgaatcTGCTATCAAAGCCTATTATCTTAAGATCGACCGGGGCACCGAAAAGGAAGAAGTGGACTCGCTCAAATGTAAAGAATGTGCTTACGTGGCAAAACGGAAAGCATATCTCAAAATGCACAACGAAACCGTCCATTTGAACGCGAAACGGTTCAAGTGCGAATACTGCGTTTACGCCACCAATCTCAAAAACAACCTCAAGATCCACGTACATTCCAtccatttgaacttgaagcTATACAGGTGCGATCAGTGCGATTTCGCTGCCAGTCGAGAACAATCCCTCAGGAGACACAAGAATTCCATacatttaaaattgaaacagTACAAATGTGACCGATGCGACTACGCGTCCAATCATAAGAGCTGTCTCAGGGTCCACATAGATAccgttcatttaaaattgaggCAATACGAATGCGACGAATGCGATTATGTTACAAACGTTAAGATTCATCTTAACATCCACATGAGCAACGTTCATTTGAAGAAGCCGAGACAGCATCAGTGTCAACTTTGCGATTACTCGACGGATCAAAAATGCAACCTGAACAGACACATGGATTCGGTCCATTTCAAATCGAAGCTGTACCAGTGTGATAAATGTGATTATAACACGAGCGATAAGTTTCACATCAGGATACACGTGAATTCCGCCCATTTGAAAGTGAAGGATTTCAAGTGTGACAAATGTGATTATGCAGCGATTTATAAACTTTCTCTGGAGAGACACATAAAGGCGGTTCATTTGAAATCGAAGCGATTCGAGTGCGATCGATGCAATTACGTGGCGAGATGTGAAAGTTTTCTTGAAGGTCACGtgaattcagttcatttaaaattgaaacagTTCAAGTGCGACCAATGTGATTACGCTACGAAGAGAAAGACTCAGCTCTTGCTTCACGTTTATTCCGTTCATTTACAGTCGAAGAAATTCAAtAAGATCGACCCTGAGGCAAAAAAGGAAGAAGTGGACTCTTTCAAATGTGGTCAATGCGATTACGTGGGGAAGCGAAAAAGAAACCTCGCAATCCACCTAAAATCCGTCCATTCCCCATCGAAGCGGTACAAATGCGACCAATGCGATTACGCCTCCAACCTCTCAGGAAATCTAAAGTATCACGTCGAAGCGGtgcatttaaaattgaaaaacttcATGTGCCATCAGTGCGACTACGGTGCTTGTCGAAAAGCGACGCTTAAACTGCACATCAACGCCGTCCACTTAAAATTGAAACCCTTCAAGTGCGATCTGTGCGACTACACCGCGAACCATAAAGTCGGTCTCAAGATTCACGTTAATTACGCTCATTTGAACATGGGAAAACTGCATCAGTGCCAACTTTGCGAATACGGCGCGGATAAAAACGCGATTTTGAAGAGACACGTGGAATCCGTTCACTTGAATCTGAAGAAATATCAGTGTTGCCAATGCGAGTTTAGTACCAACACTAAATTTTATCTTAAAGTTCACGTGGATACTGTTCATTTAAACCTGAAGAAATTCAAGTGCACCATGTGCGATTACGCAGCTAACCATAAACACGGCCTCAAGTTTCACGAAGGCTTTATATTCTGCGAAGTAATCACGATTCAACCAGTATTAATGGCCGAGTACGGAATTATAAAGAAAGAAGAAGATGTAGACATATCCGAGGAGTTTATCGTTgataatgaaataatcaaaaggGAAGATTTTGAAAAGGATCTTGAATCTACAGTAGAATCCAACGTCGGCGATTGTATGGACGACTACAAAATCGAAAAGAATGAAATAGAAGATGTAAATATATCTGAGGAGTTTAAtgttaataatgaaataatcagAAGACAAGATTACGAAGGAAATCTTGATTCTACCGTTCAATTCAACGTTGACAATTGTATGGACGAGTACAAAATTAAAAACGAAATGGAAGATTTAGATATGTCCGAGAAGTTCAATGTTGGTAATATAACAATTAAAAGAGAAGATAATGAAGGGGATCTTGGTTCAATTATCAAATCCGAGGTTGATGATGGTGAAATCCACTGGGACACAGCCACACAAGATTTGAAGGCTCCTTCGATCTCCAAGCCGCACAAATGCGGTCAATGTGATTACGCTACGAATATCAAAAGTAATCTTAATGCTCACGTAAGATCTATCCATTTGAACGTGAAAAGATACCGATGTCACCTTTGCGACTACGCCGCAGTACAGAAGGGGACTCTGAAAGCTCACATCGATTCCGTTCATTTAAATCTGAAACCGTACAAGTGTGATCAATGTGACTACGCCGCAAACCAAAAAAATTACCTCAAGGTTcacatcgatgcagttcataagAACGTGAAACAGTACCAGTGTCAGTTTTGCGATTACTCTGCAGGTCTGAAGGGAAATCTGAAAACGCACGTGAACTCCGTTCATTTAAACCTGAAACAATACAAGTGCGATCGATGCGACTACGCAGCGAATATCGAGAATAATCTCAAGATTCATTTTAAGACCgtccatttgaacttgaagcaaTTCAAATGTCACCTCTGCGATTTCGCGGCGGTACAGAGGGGAACTCTGAACATGCATCTCGATCGCGTTCATTTGAATTCCAAACAGTTCAAGTGCGATCATTGCAATTACGCTGCAAGTTTCAAATCGAATCTGAAACATCACATCAATACCgttcatttgaaactgaaaGTTTTCCAGTGTAGCCTCTGTGATTATGCTGCAAGTCGTAAGGATAATCTGAAGAAACATGTAATGGCTAATCATTTAAAATCAAAGTGA
Protein Sequence
MDEFETIKDEIEDIDISEEFIVGNEVIKRQEVGESLDSNVKSDVDDCKGDFEIKKDEIEDVDISEEIVGNVICKSEYFDEDIESAIKAYYLKIDRGTEKEEVDSLKCKECAYVAKRKAYLKMHNETVHLNAKRFKCEYCVYATNLKNNLKIHVHSIHLNLKLYRCDQCDFAASREQSLRRHKNSIHLKLKQYKCDRCDYASNHKSCLRVHIDTVHLKLRQYECDECDYVTNVKIHLNIHMSNVHLKKPRQHQCQLCDYSTDQKCNLNRHMDSVHFKSKLYQCDKCDYNTSDKFHIRIHVNSAHLKVKDFKCDKCDYAAIYKLSLERHIKAVHLKSKRFECDRCNYVARCESFLEGHVNSVHLKLKQFKCDQCDYATKRKTQLLLHVYSVHLQSKKFNKIDPEAKKEEVDSFKCGQCDYVGKRKRNLAIHLKSVHSPSKRYKCDQCDYASNLSGNLKYHVEAVHLKLKNFMCHQCDYGACRKATLKLHINAVHLKLKPFKCDLCDYTANHKVGLKIHVNYAHLNMGKLHQCQLCEYGADKNAILKRHVESVHLNLKKYQCCQCEFSTNTKFYLKVHVDTVHLNLKKFKCTMCDYAANHKHGLKFHEGFIFCEVITIQPVLMAEYGIIKKEEDVDISEEFIVDNEIIKREDFEKDLESTVESNVGDCMDDYKIEKNEIEDVNISEEFNVNNEIIRRQDYEGNLDSTVQFNVDNCMDEYKIKNEMEDLDMSEKFNVGNITIKREDNEGDLGSIIKSEVDDGEIHWDTATQDLKAPSISKPHKCGQCDYATNIKSNLNAHVRSIHLNVKRYRCHLCDYAAVQKGTLKAHIDSVHLNLKPYKCDQCDYAANQKNYLKVHIDAVHKNVKQYQCQFCDYSAGLKGNLKTHVNSVHLNLKQYKCDRCDYAANIENNLKIHFKTVHLNLKQFKCHLCDFAAVQRGTLNMHLDRVHLNSKQFKCDHCNYAASFKSNLKHHINTVHLKLKVFQCSLCDYAASRKDNLKKHVMANHLKSK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-