Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.45 28 5.6 0.1 2 23 175 195 174 195 0.92

2 6 9.4e-06 0.00058 20.4 4.9 1 23 202 224 202 224 0.98

3 6 6.4e-05 0.004 17.7 2.4 1 23 230 252 230 252 0.98

4 6 0.00021 0.013 16.1 1.1 1 23 258 280 258 280 0.97

5 6 0.16 10 7.0 1.4 1 20 285 304 285 308 0.84

6 6 8.1e-05 0.005 17.4 0.8 1 23 314 337 314 337 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.45	28	5.6	0.1	2	23	175	195	174	195	0.92
2	6	9.4e-06	0.00058	20.4	4.9	1	23	202	224	202	224	0.98
3	6	6.4e-05	0.004	17.7	2.4	1	23	230	252	230	252	0.98
4	6	0.00021	0.013	16.1	1.1	1	23	258	280	258	280	0.97
5	6	0.16	10	7.0	1.4	1	20	285	304	285	308	0.84
6	6	8.1e-05	0.005	17.4	0.8	1	23	314	337	314	337	0.92

Coding Sequence: ATGGTTTCCACTTACTATTTAATTAAATTGTTCAAGAAAGCGACATATGAACGGTTCGATAGACATCTAGATGGTGATAGCGAAAGTCATGTGAGTACATCTCGACCTCAACAGGTTGATACCGTCTGCAAATGTAGAATTTGTCTGAAGAGAGGTGATATTCCCATCTTTAATCACCCTAACCCTGATTTTTCCGTCGATATCTGCATTTTCGGCGACATAGAATTATGTGAAGACGACGAACATCCTAAGTTTTTATGTCAATCTTGTAACAAATTACTAGAAGCTGCAGTACTCTTTCGGAAAAATGCAAAAAAAACTGATGAAATATTGCGAAATGCACTAGCGAAGAGCAGCGAATATTCAAATAAATCTGGAAATGAAAGTGCCCAAGGAACAGTAGAAGAGAGTGCCAATACATCAACAGCTGCATTGCAAAACTTTTGTTCAGCTGTTGTTAGTGACAATGATATATCTGTTGATGATTCAAAGCCAAAGCGTAAGAGGTTGTTAACCAAGGTGCAATGTGGAATCTGCTTTAAAATTGTTACAAAAGCTTACTACAAGGATCACTTGGCCCTACATGATCAAACTGTAGTCAAATATGTATGTGATATTTGTGGGAAATCATTTAGGCAAAGGTGTTCTTATAGGAACCATTACTTTACACACAGTTCAGATTTCCCTCACAAATGCAAGCTATGCCCATACAGAGGTCGTAATTTGGGACTCTTAAAAACTCACATGCGTACACATACAGGAGATTACAGGTATATGTGTACAGAATGCCCAGCACGATTCTTAACTAAAAGTAACTTGAACAAGCATTCACTAAAACACAAGGAGCCAACGTTTAAATGTGATAATTGCCAGCGGGGATTCCATTCTAAACTTATTTTAGAAAGACATTTTGAAGCTGATCACCTAGGAATAAAGAACCATATTTGCAATATCTGTGGTAAAGCATTTGGTTACAGAAAAACCATGATGAGACATCAACTTGATGTTCATAAAAGAGAGAAAAGGGCAAACGGAAGAACACCTGCTTACATTGAAGCTCTTATTAAGAAATTAGACGATAACTTTTAA
Protein Sequence: MVSTYYLIKLFKKATYERFDRHLDGDSESHVSTSRPQQVDTVCKCRICLKRGDIPIFNHPNPDFSVDICIFGDIELCEDDEHPKFLCQSCNKLLEAAVLFRKNAKKTDEILRNALAKSSEYSNKSGNESAQGTVEESANTSTAALQNFCSAVVSDNDISVDDSKPKRKRLLTKVQCGICFKIVTKAYYKDHLALHDQTVVKYVCDICGKSFRQRCSYRNHYFTHSSDFPHKCKLCPYRGRNLGLLKTHMRTHTGDYRYMCTECPARFLTKSNLNKHSLKHKEPTFKCDNCQRGFHSKLILERHFEADHLGIKNHICNICGKAFGYRKTMMRHQLDVHKREKRANGRTPAYIEALIKKLDDNF

Sequence clustering based on sequence similarity using MMseqs2