Alep013431.1
Basic Information
- Insect
- Acronicta leporina
- Gene Symbol
- Runx1
- Assembly
- GCA_947256265.1
- Location
- OX366526.1:5326722-5355266[-]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 5.5e-51 2.7e-47 160.0 0.0 4 97 45 138 42 157 0.92 2 2 3.8e-18 1.8e-14 53.8 0.0 88 129 219 260 200 260 0.92
Sequence Information
- Coding Sequence
- ATGCATTTATCGAGTGAAGTGAGTTCGACTACGAACGGACTGGGCCATGAGGCACCTTCGTCGAGCTATGGGAGTTCTTTGCCGAGTCAGCCGCTGACGGCAGAGCTGTTGGCCGAAAGGACCTTGGAGGGTCTTTTGGCGGATCACCCTGGAGAGCTAGTCAAGACTGGCTGTCCCCATGTGGTATGCACAGTATTACCACCACATTGGCGATCAAACAAGACCTTGCCGGTGGCTTTCAAAGTTGTGGCGCTAGGAGAGGTTGGAGATGGTACCCTGGTCACCGTTAGAGCGGGGAACGACGAGAACTGTTCCGCAGAGCTAAGGAACTGTACAGCGGTGATGAAAAACCAGGTGGCCAAGTTTAATGACCTTAGATTCGTCGGGAGAAGCGGTAGAGGGTTGGCAATCATTGAGGTGTTAATACTTAATAAAACTTGCCTGAATCCAAAAACAATATCCAACATCTTAGTAAATCTTCCTCCTTGCAATCCGTGTGTTCGTGTTGGCACGCGGGCGCGCCTGACGGCCGACGGGTCCACAAATCAACCGCCGCAGCCGCCGCCGCGCCCGCCGACGGCAACCGAATGGGTTGACGTCTCTGCCGCGAATTCTTTACGCATTCCAAGGTCGGAACTTGCTAGATGGTTTTTATTAATTTCTCATGCAGGGAAATCGTTCACCCTGACGATAATGCTGGCGACGTCACCGCCCCAAGTGGCGACGTACCAGAAGGCCATCAAGGTGACGGTGGACGGTCCTCGGGAGCCGAGGTCGAAGACGAGGCACCACGGCTTCCACCCCTTCCACTTCGGGCCACGGTTCCCGCCTGATCCCTTGATGGGATCACTACCTTTTAAGTTGTCAGGTATAGCCCATCAGCTGGCCGGTCTACCGGGTGGAGAGTGGGGTGCGCTGGCGCGGCATTACCCTCCTCCACTACTGCCGACGCCTGCGCATTTTACACCGCACGTTTTGCCGCCGCACGCGCAACCTCAGCATGTCCCTCCACCTCCACACGAAACTGATGTGACGTCAGACAATCCGATAACAATGCACGCGCACAGTACGACAAGTCCGGCAAACTCGCGTCCAAGCTCACCGCAAGATGACGATATCTCCGTCACGGCATCCAGTTCCCCACCCCCAGATGACCGTCCAGGAGCTTTTACATCGGTCACAAGATCGAGAAAACCGTTACAACCATTACCAGCACCTTCCACTTTATTTCATAGTGCATTAGCAGCTCAATTATTCCTCAACTCCCCTTTACTTCCAACGCCACCTGCGTGGTTGTATTCCCAACTCTACGGTGGTTACGACTGGTGGCTTAGGCCGCCTCCACCTCAAGAAGACTCTAACCATTCAAGTCCTGAAAGAGAAGAGGACAGTTCAACGGCATCAGGGGTAGGGAAGAAACGTCCTGCGTCACCGGAGTGGTCAGAACAGGGGATGAGGACTCGAAGCAAGTCGCTGATTACGTCAGAAAGACGGCCAGTTGACGTTTGGCGTCCTTACTAG
- Protein Sequence
- MHLSSEVSSTTNGLGHEAPSSSYGSSLPSQPLTAELLAERTLEGLLADHPGELVKTGCPHVVCTVLPPHWRSNKTLPVAFKVVALGEVGDGTLVTVRAGNDENCSAELRNCTAVMKNQVAKFNDLRFVGRSGRGLAIIEVLILNKTCLNPKTISNILVNLPPCNPCVRVGTRARLTADGSTNQPPQPPPRPPTATEWVDVSAANSLRIPRSELARWFLLISHAGKSFTLTIMLATSPPQVATYQKAIKVTVDGPREPRSKTRHHGFHPFHFGPRFPPDPLMGSLPFKLSGIAHQLAGLPGGEWGALARHYPPPLLPTPAHFTPHVLPPHAQPQHVPPPPHETDVTSDNPITMHAHSTTSPANSRPSSPQDDDISVTASSSPPPDDRPGAFTSVTRSRKPLQPLPAPSTLFHSALAAQLFLNSPLLPTPPAWLYSQLYGGYDWWLRPPPPQEDSNHSSPEREEDSSTASGVGKKRPASPEWSEQGMRTRSKSLITSERRPVDVWRPY
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00171529; iTF_00049672; iTF_01538513; iTF_01424820; iTF_00383391;
- 90% Identity
- -
- 80% Identity
- -