Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.093 7.3 7.2 2.3 2 23 175 196 174 196 0.96

2 5 0.00068 0.054 13.9 3.5 1 23 214 238 214 238 0.98

3 5 6.8e-05 0.0053 17.0 3.0 1 23 244 268 244 268 0.96

4 5 1.9e-05 0.0015 18.8 1.8 1 23 274 299 274 299 0.95

5 5 6.4e-06 0.0005 20.3 2.0 1 23 305 327 305 327 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.093	7.3	7.2	2.3	2	23	175	196	174	196	0.96
2	5	0.00068	0.054	13.9	3.5	1	23	214	238	214	238	0.98
3	5	6.8e-05	0.0053	17.0	3.0	1	23	244	268	244	268	0.96
4	5	1.9e-05	0.0015	18.8	1.8	1	23	274	299	274	299	0.95
5	5	6.4e-06	0.0005	20.3	2.0	1	23	305	327	305	327	0.98

Coding Sequence: atgttaacaaatatattaaatgaaGGAAAGTTAAATAAACGTGTACAATATATGATTGAACATGTTTTTGAGGTTAGAAAAGATGGATTCAAGGATCATAAACCTGTAATTGAAGCCCTTGGATTGGTTGAGGAAGATGAGCAGTCTACATATTCGATAAGTTTAAATGAAGCAATAAATACTGAGGATGCTCTAAATGTTTTTAATTTTGATGAAGAATACAAAACAAATGAAGAAAAATACAAGAAGAAGTTAATAGAAGCCCTTGAATTAATGGAGGAAGATGATCAGTCCACACATTTGATTGTTGAAACAATCAATATTAAGGATGTTGAAGATGAAGAATTATATACTGAAAATGATGAGTTCTCAGGCGATAAGCTCTCACGCGATGATGAAACCAAAAAAGAACAAAAGTCCACAATGGCAAAAAAATATAGAAGACTTTCAAAAGAAGATTCAGCTTCTGGTAAGCTAAGCAAGTTTATGAGGCAAAAAGAGGCACAATGGCAAAGGAAACAAAAATGTGAATTATGTAAAAGAACCCTTAGTATAAGCTTTCTATACAAACATATGAAGTCAAAGCATAGATTAAATTACAAAAATCAGGCAATAATAAATGCAGAAAGACGTAGAGTTTATAAATGCCAACATCCTAATTGTGGTAAAAACTACTTCGAATCCAATCATTTAAAAGCTCATGAACGTGTTCATACGGGTGAACGTCCATTCATATGTAAATGGGAAAATTGTGGTAAAAAATACTTCAAATCCAGTCATTTAAAAACTCATGAACGTGTTCATACTGGTGAACGTCCATTCATATGTAAATGGGAAAATTGTGATAGAAAATTTTCCCGATCTAGCTTATTATCAAGGCATAAAACGACGACACACACTCGAGAAAAAAAATTTGTATGTAATATTTGTCAAAAGAAATTTACTATCTATGACTATCTTTCTAAGCATATCAAACGGCATGGAAAAGATAAAGTAGTAAATAATACATCAGTACCAGAAATTATAAAAAAATATTCCCTAATAAGCGGTCGTTTGTATTCAATAAACAACTAA
Protein Sequence: MLTNILNEGKLNKRVQYMIEHVFEVRKDGFKDHKPVIEALGLVEEDEQSTYSISLNEAINTEDALNVFNFDEEYKTNEEKYKKKLIEALELMEEDDQSTHLIVETINIKDVEDEELYTENDEFSGDKLSRDDETKKEQKSTMAKKYRRLSKEDSASGKLSKFMRQKEAQWQRKQKCELCKRTLSISFLYKHMKSKHRLNYKNQAIINAERRRVYKCQHPNCGKNYFESNHLKAHERVHTGERPFICKWENCGKKYFKSSHLKTHERVHTGERPFICKWENCDRKFSRSSLLSRHKTTTHTREKKFVCNICQKKFTIYDYLSKHIKRHGKDKVVNNTSVPEIIKKYSLISGRLYSINN

Sequence clustering based on sequence similarity using MMseqs2