Alat022566.1
Basic Information
- Insect
- Acleris laterana
- Gene Symbol
- Runx3_1
- Assembly
- GCA_963966035.1
- Location
- OZ014451.1:10943337-10943732[+]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 2.2e-52 1.5e-48 164.8 0.0 4 94 40 130 37 131 0.97
Sequence Information
- Coding Sequence
- ATGCACCTGACGGGTGCCAGCAGCGGCGCCGTGTCGCCTGACACCAGCTCGACGCTGCTGCACGAGACTTACACGAAGATGACGTCCGACATCTTAGCGGAGCGGACGTTGGGCGACTTCATATCGGAGCATCCTGGGGAGTTGGTGAGGACAGGGAGTCCTCACTTCGTCTGCACAGTTTTACCTCCTCACTGGCGCTCCAACAAGACGTTGCCAGTGGCGTTCAAGGTGGTGGCTTTGGGTGATGTGGGCGACGGCACGATGGTGACCGTCCGCGCCGGGAACGACGAGAACTGCTGTGCGGAGCTGCGGAACAGCTCGGCGGTGATGAAGAACCAGGTGGCCAAGTTTAATGACCTGAGGTTCGTCGGCCGCAGCGGTCGCGGTGAGTGCTGA
- Protein Sequence
- MHLTGASSGAVSPDTSSTLLHETYTKMTSDILAERTLGDFISEHPGELVRTGSPHFVCTVLPPHWRSNKTLPVAFKVVALGDVGDGTMVTVRAGNDENCCAELRNSSAVMKNQVAKFNDLRFVGRSGRGEC
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00011715; iTF_00012710; iTF_00719983; iTF_01302066; iTF_00146175; iTF_01547300; iTF_01129831; iTF_00839213; iTF_00204149; iTF_00922676; iTF_01222261; iTF_01173048; iTF_01022000; iTF_00325145; iTF_00971007; iTF_01082211; iTF_00871072;
- 90% Identity
- iTF_01222261;
- 80% Identity
- iTF_01463938;