Basic Information

Gene Symbol
L
Assembly
GCA_943193655.1
Location
CALPDL010000127.1:1743285-1747797[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 0.52 35 5.4 5.8 1 23 3 25 3 25 0.97
2 16 5.2e-07 3.6e-05 24.2 2.7 1 23 31 53 31 53 0.99
3 16 2.1e-05 0.0015 19.2 0.1 1 23 59 81 59 81 0.98
4 16 0.0002 0.013 16.1 0.0 2 23 97 119 96 119 0.95
5 16 4.9 3.4e+02 2.3 0.1 9 23 150 165 146 165 0.93
6 16 0.31 21 6.1 0.1 3 23 217 237 216 237 0.97
7 16 0.54 37 5.3 0.0 3 20 252 269 251 270 0.86
8 16 0.00025 0.017 15.8 0.6 1 23 280 303 280 303 0.94
9 16 0.027 1.8 9.4 0.1 1 23 308 331 308 331 0.92
10 16 0.013 0.89 10.4 0.2 1 23 384 408 384 409 0.93
11 16 0.00016 0.011 16.4 0.1 2 23 467 488 466 488 0.96
12 16 0.048 3.3 8.6 0.0 1 23 496 518 496 518 0.98
13 16 1.4 94 4.0 0.7 2 23 526 547 525 548 0.93
14 16 0.72 49 4.9 0.3 1 23 622 644 622 644 0.94
15 16 0.0046 0.32 11.8 0.1 1 20 652 671 652 674 0.95
16 16 0.082 5.6 7.9 0.4 1 23 681 703 681 703 0.94

Sequence Information

Coding Sequence
ATGCCGTTCCGCTGCGAGTTTTGCTCCCGACTCTTCAAGCACAAGCGCTCCCGGGATAGGCACGTCAAGCTCCACACCGGCGACCGCAAGTACCGCTGTGCGCATTGTCCTGCTGCGTTTTCTAGAAGCGATCACTTGAAGATTCACATGAAGACTCATGACAACCAGAAGCCTTTCCAGTGCACAGTATGCAACCGTGGCTATAACACCGCGGCGGCGCTGACGTCGCACATGCAGGGTCACAAGAGGGACCGCGAGGGCCGCGAGCCCGATCGGCGCCGACCGCTGCGGTGCCCGCGCTGTGGAGATGCTTTTAGACGACCGGACTTACTTCAGGCTCATCTAGTTACGGCTCATGGCGTAGAAGCTGCTGCAATTACGCCACCAAGACGAGTCGCTTCGCAGCCACCCCCCACGTTACTCGCGTGCATATACTGCACTCGCGATACTTTCACTAGCATGGAACAACTACAACTCCACGTACGTGCTGCACATTCAGCACTTTTAAATGGAGAAACTCCATTACCTGTAGATCAACCTGCACCTACAGATCTTAGTAGAAGGGCACCCGATGATGGCCTGCCGATTAAAAGACCAAGGTCCGGATCTGGAACACCTCAAACTGCATTGTCTCCTAGTACTCTATTGTGCAATCAATGTGATGCAGCGCTACCAGATTTTGAAGCATTCCGAACTCACTTAAAAGGTCACCTGGAAGAAGGTGGAGAATTGGGAAGATCAAGTCCCGCTCCGTGTCTTCATTGCGGTGCTACATTCGCAGACGCTGCGGCTTCTGAACGCCATTTAGCAGCATATTATCTCGCTGTGTCATGCGAGTACACCTGTCACAGCTGTGCCAGAAGTTTTTCAGCTCCAGATGATCTACAGAAACATCTTTTGGATTTGCATGCTCATCATTTGTATCGATGCTCTCTTTGCAAAGAAATTTTTGACTCCAAAGTTGCTATTCAGGTGCACTTTGCGGTGGCTCATAGTGGAGAAAACAAAATTTGGATGTGTCGTTCATGTGGGGGTACTGCTGGGCCATTGCGGTCGGAGGCGGAGGGCGCAGCGCATGTTCGCTCGAGGCATGCAGCGGCCCGTTGCGCGTGCGGTGCCATCGGCCCACGACAACGGCAACACCGGGCATACCGCTGTCCAGTACCAGCTTGCACAGATACTTTCGCTGTGCAGTATTTACTAGAACGACATATGCAGGCACATCATGCAGCACCGCATCAGGCGTTGAACGGTGAGATGAGGGTTAAAAGATTGGAAAATAACAATGCTCCAGAAGGGACCGATGGCAATTGCTCACCATGTGCGCCTGGTGCAGACGGTAATGGTACAGTTCCGACTAGTGAAGACCGGCGTCGCAAGAACGGTGCGGTTGCTTTGCAATGTGCGTACTGCGGCGAGCGGACGCGCAGCCGGGCTGAGTTGGAAGCTCACACAAGGGCGCATTCTGGAGCCGCGGCCGCTAGACATAAATGCCTCATATGCGATGAAGTATTGCCGTCTGCTGCCGTGTTAGCTGAACATAAACTTACACATTGCAAGGTTGTTGCAGGAGATACATGCGCCAGATGTCGAGCTCGATTACCGTCCGAAGAATCCTTCTTAACCCATATGGCACGACACCACCCTACTCTACCAGCGCCCTGCGTTGTTTGCCGACAAACACTAGCGTCCGAAGCTGAAGCACGACTTCATGCCCGTTTCCACTTGCGTCCAGCCGAAGATGAACAAAGATGCGCTATTTGTTTAAGAGCATTGACTGAGAGCGAGGCAGGGGAAGGGGCCCGGGCCTGCTCAGCGTGCTATGCACGACACGCCGCACCCCGCCTGACACAACCTGCAGATCACGACTGCCGCCTTTGCCGTCGGGCCCTAGGATCCCCTACACGACTTCAAGCACATCTGATTGAGCACACATTCGCAGGCATAAGTGCATTCACGTGCTATCTATGTTCAGCAGTATTTACTAGTGCAGTTGGCTTACAACGCCATCTCCCCGAACATGCTGCAGCTCCAAAGCCCTTCGATTGCGGTCGATGCGGCATGAAATTTTTCTTCCGAGCTGAACTTGATAACCATGCGTTCGTACACTTAGAGGAAGCAGAGATAGCCCAGCGGGCATTTTATGAGGCTTACGCGAGAGGCGCAGCATCAGCGTGGGCTGCATTAGCTCCGCCGGATGCTGTGCCACAGGCACCAATGAATGTTCCTGCGTCACCAGTCACTGAAGTTAAACGGGAGCCAGAAATAAAAGAAGAACGTAATAATGATGAGTATATAGAAGTTTCATCGCCTGCTCCTCCAGTTCCACCCCCGCAGGCGGTGAACACTCCTCCAATGGTGGTAAAACAAGAAAAACCCGATGAAGACTGA
Protein Sequence
MPFRCEFCSRLFKHKRSRDRHVKLHTGDRKYRCAHCPAAFSRSDHLKIHMKTHDNQKPFQCTVCNRGYNTAAALTSHMQGHKRDREGREPDRRRPLRCPRCGDAFRRPDLLQAHLVTAHGVEAAAITPPRRVASQPPPTLLACIYCTRDTFTSMEQLQLHVRAAHSALLNGETPLPVDQPAPTDLSRRAPDDGLPIKRPRSGSGTPQTALSPSTLLCNQCDAALPDFEAFRTHLKGHLEEGGELGRSSPAPCLHCGATFADAAASERHLAAYYLAVSCEYTCHSCARSFSAPDDLQKHLLDLHAHHLYRCSLCKEIFDSKVAIQVHFAVAHSGENKIWMCRSCGGTAGPLRSEAEGAAHVRSRHAAARCACGAIGPRQRQHRAYRCPVPACTDTFAVQYLLERHMQAHHAAPHQALNGEMRVKRLENNNAPEGTDGNCSPCAPGADGNGTVPTSEDRRRKNGAVALQCAYCGERTRSRAELEAHTRAHSGAAAARHKCLICDEVLPSAAVLAEHKLTHCKVVAGDTCARCRARLPSEESFLTHMARHHPTLPAPCVVCRQTLASEAEARLHARFHLRPAEDEQRCAICLRALTESEAGEGARACSACYARHAAPRLTQPADHDCRLCRRALGSPTRLQAHLIEHTFAGISAFTCYLCSAVFTSAVGLQRHLPEHAAAPKPFDCGRCGMKFFFRAELDNHAFVHLEEAEIAQRAFYEAYARGAASAWAALAPPDAVPQAPMNVPASPVTEVKREPEIKEERNNDEYIEVSSPAPPVPPPQAVNTPPMVVKQEKPDED

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01437318;
90% Identity
iTF_01081822;
80% Identity
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