Basic Information

Gene Symbol
tp53
Assembly
GCA_034766995.1
Location
CM068323.1:25914210-25918981[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 14 0.01 1.4 10.7 2.2 2 23 611 633 610 633 0.97
2 14 0.7 99 4.9 0.0 1 23 636 659 636 659 0.94
3 14 3.1e-05 0.0043 18.6 0.1 1 23 698 720 698 720 0.97
4 14 0.00034 0.047 15.3 4.9 1 23 726 748 726 748 0.98
5 14 4.9e-07 7e-05 24.2 0.1 1 23 756 778 756 778 0.99
6 14 4.8e-06 0.00067 21.1 1.0 1 23 792 814 792 814 0.97
7 14 0.042 5.9 8.7 1.3 3 23 822 842 820 842 0.95
8 14 5.6e-07 7.9e-05 24.0 0.4 1 23 848 870 848 870 0.98
9 14 3.5e-05 0.0049 18.4 0.5 1 23 876 898 876 898 0.98
10 14 4.7e-07 6.7e-05 24.3 2.4 3 23 906 926 904 926 0.96
11 14 9.5e-08 1.3e-05 26.5 0.1 2 23 932 953 931 953 0.98
12 14 3.7e-05 0.0053 18.3 0.3 1 23 959 981 959 981 0.97
13 14 0.0005 0.07 14.8 0.2 3 23 989 1009 987 1009 0.97
14 14 0.0043 0.6 11.8 1.0 3 23 1017 1037 1015 1037 0.97

Sequence Information

Coding Sequence
ATGTCGCAGTTATCGAACATTCTCAGTGATGAAATGTACGAGGATATCACGAAAGATCCGAACCTTAACGAGATCCTGTACTCGTCCGACCTCGTGCACGTAGATTCGGAAATAAATGATTCGTGTATCGCCGTCGATCCGGCGAACGATTTCGTTTCAATCGGTCGTGATATTTCGCAGATACCCTTCTTCGTCGAGGGCGAATGCGAAACTATTCCGATCGCGTACGGTGGCCCGGCGCAGATGATCCGCCAGATCCCGGCGAACGAGGAATACCCGGGCGAGTACGATTTCAATTTCAAGTTGAGCAACGGGCCGTCCGGGAAGAAATCTTGGGAGTTCTCTCAAGAGCTCAACAAAGTGTACATCGATATGGGCGCGAAACTGTCCGTCGAGTTCAAGTGGACGCCGCCGAACGAGTGGCTTTACGTCCGCGCGACGCCGCGTTTCTCCGAACCGCAGCACGCCGACGAATCGGTCCGACGATGCATCACGCACTCGAACGACAAACACCCGACGAACAGAGATTGTTCGCTCGACATGCTGCCGCACGTGATCCGGTGCTACAACGAGGGCTCCGAATACGTCACGACCGACAAAGAGCTGAGCGTCCGGACTCCGCTCGGGAGCCCGCAGCGCGGCGTCGAACGCGTGACGCTGCTGTACTCGTTCATGTGCAAGAACTCGTGCACGTCCGGCATGAACCGGAGACCCATACAGGTCGTGTACACTCTCGAGGACGCGAACGGGGTCGTCCTCGGAAGGCGCAAGCACGACGTACGTATATGCAGTTGCCCGAAGAGGGACCGTGAGAAGGACGAGAGCGTGAACGGCGCCGAAAAGCATCCGCCAGGAAAGAAGCGTAAGGTCGGCGCCGGCAACGGTCAGAAGACGACGTCCCGCGTGAAGGAAGAACCGCCGTCCCTCGAAACGGTCTGGATGCCTCAGGTACCCTCCGAACGCGCCTCGAACCACCTCCTCGTCCCGGATCCCCGATTTCCCGTCCGTGTCCCGCCCGTTCCCCGGTACTTTCGTGTCGTCGGGCAGGAGAACAAGAGAAAAATCCTGAACTACGCGTACAACCTGCTGGCAGGAGAAGCGAGGAGGTTCCAGGTGCAGGAGCCTTACGAATCCGTGATCGACGAGATCGAATCGCTGATAGTTGCCGTTCGAAGACGGCACGGTTATCGGAATATCCGTAGACAACGATTATTAATAGACGTTTCGTCGGAATTTTTTTGGGCGAGGGTAAAAGTGTTCATTCGTAAGAATGTACTCGAGACGTATTGTGAACACTGTTTCGTGAAGATGGAACTCCTCGATAGTTCGATAGCAATGTTAGATAAACGAATCGAGGTGCCGAGTGATTTTTCGAATGTTTGCCGAGTGTGTGTAACATCTTTCGCGAGTAAAATGATTCCGATTTTTGAGAAATCCGCAGGGGAGGGCGAAACGTCCGATTCGAATTTAGCGATGAAAATAATGGCGTGCGCTACAGTAAAATTGAGTAGTGAAGACGGGCTTCCGGGAACCGTCTGCCCGGGCTGTTATCAGAAAATAAACGACGCGTATTCATTCAAATGTTTGTGCGAGCAGTCGAACCGTCTCCTACAGAGCTACTTCTCGAATAAATCGGAAAGTGGCACCGTTGTCGAGAAATCGATCGCCGATCGGTGCGAGCCCGGCACACAACTCGAACGAGTCGACGCTCGTGGTGATAAGAGATTCGGGGAGGATCCGCCCGACGAGAGCGAGTCGATCGATCCGGCAGACGCCGACGAAGTAGAACGGTCCGATGACGGATCTACGTCCGGAAAGTGTTCCGAGTCGAAGTGCAAGCTATGCACGGAGGTCCTGTGCGATTCCGACAGTCTGTTGGACCACTACCGTCGTCGTCACGGTGCCCACGTCTGCAACACGTGCCTCGATGTCTTCGCCGGGCCGGCCGATCTGATCGAGCACGTGAAACTCGCGCACGAGCCCGAGCCGGGCCTGTACTGCCGCGTGTGCCACGAGTGGTTCCGGTGCGAGGTCCGGTTCGCCGATCACGAACGGTCGCACGGGCGCGACGCGCCGGACGACGGTCGCAGGTTCGTCTGCGTCGTGTGCAATAAATCTTATGCGAAGGCGAAGAACCTCGAGGCGCACATGGGCGTGCATTCCGGCGACGAGCCGTTCGTGTGTCCGACGTGCGGGAAACGGTTCTGCCAGAGTCGTGCGTACGCGTGCCACATGAGAACGCACGCGGCTCCGAGCGTCCGGAGGTACGAATGTCCGGAGTGCGGCGAACGGTTCGACCGGAACGGGCAGCTGAGCGCGCACGCGAGGACGCACGGGAACGTCGCCGCCGCCGCGGCAGCGGCGTCGAAGTCGCACGTGTGCGGCGTGTGCGGAAAGAATTACTGTAACGCCGGCAATCTAGCGTCGCACATGCGGCTGCACACAGGCGAGAAGCCGTACGGCTGTAACGTGTGCGGCCGACGCTTCGCTCAGAGTAACGCGCACTCGTACCACATGAAGCTGCACTCGGGCGAACGGCCGTACAAGTGCGACGTGTGTCCGAAAGCGTTCACGACGAACGGCCAGCTCGTCAACCACAGGAGGCTGCACACCGGCGAGAAGCCGTTCGAGTGCGGCGTGTGCGGGAAGAGGTTCACGCAGAAGGTCGCCCGCACTGTCCACACGATGACCCACACCGGCGACAGGTCGCACTTGTGCAACGTGTGCGGCAAGACGTACTACCAGAGTAGCCAGCTGACCGAACACATGAGGACGCACACCGGCGCGTCGGTCCAGTGCAGCGTGTGCGGCAAGAGCTACACGACAGCGGGGAACCTCGCCGCGCACATGAAGACGCACACCGGGTCCAAGTCGCACGTGTGTCCCGTCTGCGGCAAGGGGTTCTACTTTGCGAACAAGCTGGCGAAGCACGCGCGCGTGCACACCGGCGAAAGGCCGTTCGGGTGTGTCGAGTGCTCGAAGAGGTTCGCGAGCACGGACGTGCTGAACGTGCACATGCGCGTGCACACCGGACACCGGCCGTACGGGTGCGGCGAGTGCGAGAGGGCGTTCGCGACGAATTCGCAGCTGCGGTGCCATGCGAAGACGCACGACGCGAGGAAGTTCGCGAAGACGACCGACCCGGAGGAACGGCTCCGGTCGAAGACGGACGAGCCCGTTCATCGTTCGAGTCgCAAATTAACAATGAAAAGTACACGTAGTATATTTTCGCACCGTTTTGTGTCGAACGCGGGGACCGTTTGTGACGACCGGCCGCGTGGAGGGTCGACCGCGGATGTCGATCCTCGACGCGCGTCAGCGAGCAGTCGGAGGAACGGACCGTTTCGACGGCGACGACCGCGTCGATAA
Protein Sequence
MSQLSNILSDEMYEDITKDPNLNEILYSSDLVHVDSEINDSCIAVDPANDFVSIGRDISQIPFFVEGECETIPIAYGGPAQMIRQIPANEEYPGEYDFNFKLSNGPSGKKSWEFSQELNKVYIDMGAKLSVEFKWTPPNEWLYVRATPRFSEPQHADESVRRCITHSNDKHPTNRDCSLDMLPHVIRCYNEGSEYVTTDKELSVRTPLGSPQRGVERVTLLYSFMCKNSCTSGMNRRPIQVVYTLEDANGVVLGRRKHDVRICSCPKRDREKDESVNGAEKHPPGKKRKVGAGNGQKTTSRVKEEPPSLETVWMPQVPSERASNHLLVPDPRFPVRVPPVPRYFRVVGQENKRKILNYAYNLLAGEARRFQVQEPYESVIDEIESLIVAVRRRHGYRNIRRQRLLIDVSSEFFWARVKVFIRKNVLETYCEHCFVKMELLDSSIAMLDKRIEVPSDFSNVCRVCVTSFASKMIPIFEKSAGEGETSDSNLAMKIMACATVKLSSEDGLPGTVCPGCYQKINDAYSFKCLCEQSNRLLQSYFSNKSESGTVVEKSIADRCEPGTQLERVDARGDKRFGEDPPDESESIDPADADEVERSDDGSTSGKCSESKCKLCTEVLCDSDSLLDHYRRRHGAHVCNTCLDVFAGPADLIEHVKLAHEPEPGLYCRVCHEWFRCEVRFADHERSHGRDAPDDGRRFVCVVCNKSYAKAKNLEAHMGVHSGDEPFVCPTCGKRFCQSRAYACHMRTHAAPSVRRYECPECGERFDRNGQLSAHARTHGNVAAAAAAASKSHVCGVCGKNYCNAGNLASHMRLHTGEKPYGCNVCGRRFAQSNAHSYHMKLHSGERPYKCDVCPKAFTTNGQLVNHRRLHTGEKPFECGVCGKRFTQKVARTVHTMTHTGDRSHLCNVCGKTYYQSSQLTEHMRTHTGASVQCSVCGKSYTTAGNLAAHMKTHTGSKSHVCPVCGKGFYFANKLAKHARVHTGERPFGCVECSKRFASTDVLNVHMRVHTGHRPYGCGECERAFATNSQLRCHAKTHDARKFAKTTDPEERLRSKTDEPVHRSSRKLTMKSTRSIFSHRFVSNAGTVCDDRPRGGSTADVDPRRASASSRRNGPFRRRRPRR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00004447;
90% Identity
iTF_00004447;
80% Identity
iTF_00004447;