Basic Information

Gene Symbol
-
Assembly
GCA_905340225.1
Location
HG996513.1:2267727-2281756[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.029 2.1 9.3 0.1 1 20 123 142 123 144 0.94
2 10 0.49 36 5.4 0.3 2 23 172 194 171 194 0.92
3 10 1.4 1e+02 3.9 3.3 1 23 217 239 217 239 0.96
4 10 0.00058 0.042 14.6 0.8 1 23 243 265 243 265 0.98
5 10 0.0058 0.42 11.5 1.2 1 23 270 293 270 293 0.92
6 10 0.013 0.94 10.4 0.4 2 23 301 323 300 323 0.93
7 10 0.00022 0.016 15.9 6.1 1 23 330 352 330 353 0.95
8 10 0.0042 0.31 11.9 0.9 1 23 359 381 359 381 0.95
9 10 9.1e-07 6.7e-05 23.4 1.1 2 23 388 409 387 409 0.95
10 10 1.9e-05 0.0014 19.3 4.1 1 23 415 437 415 437 0.98

Sequence Information

Coding Sequence
ATGTTTAGTGTATCTAATATAGTGAAGGTGGAAGTGCAAGGCGAAGATGATTCTGATGACAACGCGTCGGGCGATGACGGGTTATCTGGTGCTGAATACGACGTTCCAATTAAAACTGAAGACTTGGACGATCCAAAGCCGAAGAAACGTGCGGCTAAAACCACGCCCACACGCGCCAAAAAGGCGAAAACCGACAACGGAGAGACTTCCACAAAACGAACGGACGACGACCCGCCCAAACGCAGGAAAAGGAAAAAGAAATCGGATGAAAGCGCGACCCCTGAGCGCGTTGAACACAGGGTCAACTTGACCGCTATACTACAGTACTCGAATGCGAGCCCCTTTAGGGACAAAACTATCAGGGGCTTCTCCTGTCTCTATTGCGCTAAAGCCTTCCCCGATATACAGACACTCCGCGACCACACAGCGCAGCAATCGGAAAAAGACAAAATCAACACGATTATTGACTACAAATTAAGCTATAACCCCATAAAAGTCGATATCACAGACTTACATTGCACTGTATGCAATCTAGGCATGAAAGACCTCAACGATCTCAAGGACCATTTAGTCTCCATCCACAATAAGACCATTTATAAGCATATTAAAGACATTATACTACCTTTTCGTTTAGAAGACGGTCATAATTTCACATGCGTTGTTTGTTCAGTAGTCCATATATCGTTTAAGAACCTATACCATCATATGAGTAGTCACTATAGGAATTACTGCTGTAAGAAATGCGGTGCAGGATACATAACGATAGCAGCGCTACGGAAACATGGCAAAACTCACGCCCAAGGCATCTTTCCGTGCGATTTCTGCGACAAATCTTATACGTCGCTCACAAAAAAACGGAATCATGAGAAAGGGGTACACACGGGCGGTTGGCTCCGAAACAAATGTCCGCATTGTCCGGAAATCTTTGTCAGCTACTACGATAGGAGCGAGCATCTTGTCAAAGTACATAACCAGACGCCAGTTATATACCCTTGTAATGCATGCAATAAAACTTATAAGAAGAAATTTGAGCTTAACAGGCATATCAAACATCACCATCTGCAGCAACGTAGTTTCTTATGCGATAAATGTAATGCTAAGTTCTTCTCCAAACGCGGCTTGGCCGACCACTTGTCGAGACACTCTGGTGGCGAAGTCTGTTCCTGCGCTGTCTGTGGTAAGGCCTTCTCTAGGGCTCGGACCTTGAAAGAGCATATGAAAATACATGAGGACGACAAGAGGTTCCAATGTGAGATTTGTCAGAAGACTTTCATGCAAAAATGCAGTTTGAAAAGCCATGTGCGCCTCCACCAAGATGATTTGGACATTTTCAAGGAGTTTGATGATGTTAAGCACCTCATTGATAATAGGGAGTTGACGTTGAAGCAGATAGCGGCTGAGAGTAAAAGTAAGGCGCAAGCAGAGAAAACCAAGGAGCTCTATATGTAG
Protein Sequence
MFSVSNIVKVEVQGEDDSDDNASGDDGLSGAEYDVPIKTEDLDDPKPKKRAAKTTPTRAKKAKTDNGETSTKRTDDDPPKRRKRKKKSDESATPERVEHRVNLTAILQYSNASPFRDKTIRGFSCLYCAKAFPDIQTLRDHTAQQSEKDKINTIIDYKLSYNPIKVDITDLHCTVCNLGMKDLNDLKDHLVSIHNKTIYKHIKDIILPFRLEDGHNFTCVVCSVVHISFKNLYHHMSSHYRNYCCKKCGAGYITIAALRKHGKTHAQGIFPCDFCDKSYTSLTKKRNHEKGVHTGGWLRNKCPHCPEIFVSYYDRSEHLVKVHNQTPVIYPCNACNKTYKKKFELNRHIKHHHLQQRSFLCDKCNAKFFSKRGLADHLSRHSGGEVCSCAVCGKAFSRARTLKEHMKIHEDDKRFQCEICQKTFMQKCSLKSHVRLHQDDLDIFKEFDDVKHLIDNRELTLKQIAAESKSKAQAEKTKELYM